Bovine (Bos taurus) IGH locus on chromosome 21
- The bovine (Bos taurus) IGH locus is on chromosome 21 at 21q24.
The orientation of the locus is reverse (REV).
- The bovine (Bos taurus) IGH locus spans 673 kilobases (kb),
from 10 kb upstream of the most 5' gene in the locus, IGHV3-47 (P), to 10 kb
downstream of the most 3' gene in the locus, IGHA (F).
The Locus representation
encompasses 670 kb.
- The bovine (Bos taurus) IGH locus consists of 47
IGHV genes belonging to 3 IGHV subgroups, 23 IGHD genes belonging to
9 IGHD set, 12 IGHJ genes belonging to 2 IGHJ set, and 11 IGHC
genes [1].
- The IGHV genes span 308
kilobases (kb), the IGHD genes span 113
kilobases (kb), the IGHJ genes span 11
kilobases (kb) and the IGHC genes span 246
kilobases (kb).
Clusters
The bovine (
Bos taurus) IGH genes are localized in 4 CLUSTER:
- first CLUSTER includes 44 IGHV genes belonging to 3 subgroups (12 F and 32 P), 5 IGHD belonging to 5 subgroups (4-5 F and 0-1 ORF), 6 IGHJ (2 F, 3 ORF and 1 P) and 2 IGHC (1 F and 1 P)
- second CLUSTER includes 1 IGHV genes belonging to 1 subgroup (P), 5 IGHD belonging to 5 subgroups (4 F and 1 ORF) and 1 IGHC (P)
- third CLUSTER includes 1 IGHV genes belonging to 1 subgroup (P), 6 IGHD belonging to 6 subgroups (5 F and 1 ORF) and 1 IGHC (P)
- fourth CLUSTER includes 1 IGHV genes belonging to 1 subgroup (P), 7 IGHD belonging to 7 subgroups (F), 6 IGHJ (1 F, 4 ORF and 1 P) and 7 IGHC (6 F, 0-1 ORF and 0-1 P)
| CLUSTER |
IMGT group |
Functional |
ORF |
Pseudogene |
Total |
| First CLUSTER |
IGHV |
12 |
0 |
32 |
44 |
| IGHD |
4(+1)* |
(1)* |
0 |
5 |
| IGHJ |
2 |
3 |
1 |
6 |
| IGHC |
1 |
0 |
1 |
2 |
| Second CLUSTER |
IGHV |
0 |
0 |
1 |
1 |
| IGHD |
4 |
1 |
0 |
5 |
| IGHC |
0 |
0 |
1 |
1 |
| Third CLUSTER |
IGHV |
0 |
0 |
1 |
1 |
| IGHD |
5 |
1 |
0 |
6 |
| IGHC |
0 |
0 |
1 |
1 |
| Fourth CLUSTER |
IGHV |
0 |
0 |
1 |
1 |
| IGHD |
7 |
0 |
0 |
7 |
| IGHJ |
1 |
4 |
1 |
6 |
| IGHC |
6 |
(1)** |
(1)** |
7 |
* FUNCTIONAL or ORF
** ORF or pseudogene
- Created:
- 21/12/2017
- Last updated:
- Wednesday, 12-Jun-2024 16:02:36 CEST
- Author:
- Perrine Pégorier
