Bovine (Bos taurus) TRB locus on chromosome 4
- The bovine (Bos taurus) TRB locus is on chromosome 4.
The orientation of the locus is forward (FWD).
- The bovine (Bos taurus) TRB locus spans 649836 kilobases (kb),
from 10 kb upstream of the most 5' gene in the locus, TRBV1 (F),
to 10 kb downstream of the most 3' gene in the locus, TRBV30 (F).
The Locus representation
encompasses 650 kb including the 5' borne MOXD2 and not including the 3' borne EPHB6.
- The bovine (Bos taurus) TRB locus consists of 123 TRBV genes belonging to 28 TRBV subgroups and 2 clans, 3 TRBD genes, 19 TRBJ genes and 3 TRBC genes.
- The TRBV genes span 535 kilobases (kb),
the TRBD genes span 11 kilobases (kb),
the TRBJ genes span 10 kilobases (kb),
and the TRBC gene spans 19 kilobases (kb).
Clusters
- The TRBV genes are localized in 2 V-CLUSTER:
- the 5' V-CLUSTER, classically in 5' of the TRBD, TRBJ and TRBC,
includes 122 TRBV genes belonging to 27 subgroups and 2 clans
(61 genes are functional, 9 genes are ORF and 52 genes are pseudogenes).
- the 3' V-CLUSTER, downstream of the TRBC in inverted orientation, includes 1 TRBV gene (functional).
- The TRBD, TRBJ and TRBC genes are localized in three D-J-C-CLUSTER between the 5' V-CLUSTER and the 3' V-CLUSTER:
- the first D-J-C-CLUSTER, in 3' of the 5' V-CLUSTER,
includes 1 TRBD gene (functional),
6 TRBJ genes (3 genes are functional and 3 genes are ORF) and 1 TRBC gene (functional).
The most C-proximal TRBJ gene, TRBJ1-6 is localized 2763 bp in 5' of TRBC1.
- the second D-J-C-CLUSTER,
includes 1 TRBD gene (functional),
6 TRBJ genes (5 genes are functional and 1 gene is pseudogene) and 1 TRBC gene (functional).
The most C-proximal TRBJ gene, TRBJ3-5, is localized 3735 bp in 5' of TRBC3.
- the third D-J-C-CLUSTER, in 5' of the 3' V-CLUSTER,
includes 1 TRBD gene (functional),
7 TRBJ genes (functional) and 1 TRBC gene (functional).
The most C-proximal TRBJ gene, TRBJ2-7, is localized 2658 bp in 5' of TRBC2.
Bornes of the bovine (Bos taurus) TRB locus
- MOXD2 (5' borne) has been identified 6 kb upstream of
TRBV1, the most 5' gene in the locus.
- EPHB6 (3' borne) has been identified 43 kb downstream of
TRBV30, the most 3' gene in the locus.
- Created:
- 01/12/2021
- Last updated:
- Friday, 22-Sep-2023 18:22:16 CEST
- Author:
- Alexandre Albani, Gérard Lefranc, Sofia Kossida, Marie-Paule Lefranc
