IMGT Repertoire (IG and TR)

Dog (Canis lupus familiaris) TRD locus on chromosome 8

The dog (Canis lupus familiaris) TRD locus is on chromosome 8. The orientation of the locus is forward (FWD).
The dog (Canis lupus familiaris) TRA/TRD locus spans 762 kilobases (kb), from 10 kb upstream of the most 5' gene in the locus, TRAV43-1 (F), to 10 kb downstream of the most 3' gene in the locus, TRAC (F). The Locus representation encompasses 800 kb including the 3' borne DAD1.
The dog (Canis lupus familiaris) TRD locus consists of 5 TRDV genes belonging to 5 TRDV subgroups,2 TRDD, 4 TRDJ segments and 1 TRDC gene.
The TRDV genes span 294 kilobases (kb), the TRDJ genes span 113 kilobases (kb), the TRDD genes span 35 kilobases (kb), the TRDC gene spans 6 kilobases (kb)

The TRDV genes are localized in 2 V-CLUSTER:
- the 5' V-CLUSTER, classically in 5' of the TRDD, TRDJ and TRDC, includes 4 TRDV genes belonging to 4 subgroups (2 genes are functional, and 2 genes are pseudogene).
- the 3' V-CLUSTER, downstream of the TRDC in inverted orientation, includes 1 TRDV gene (functional).
The TRDD, TRDJ and TRDC genes are localized in one D-J-C-CLUSTER between the 5' V-CLUSTER and the 3' V-CLUSTER:
- The CLUSTER includes 2 TRDD genes belonging to 2 subgroups functional, 4 TRDJ (3 genes are functional and 1 gene are ORF) and 1 TRDC functional .

References:

[1]	Martin J. et al. Immunogenetics 2018 Apr;70(4):223-236 (2018) Sep 19. doi: 10.1007/s00251-017-1028-0. Epub 2017 Sep 19. PMID: 26809968

More information:
Gene table: dog (Canis lupus familiaris) TRDV
Gene table: dog (Canis lupus familiaris) TRDD
Gene table: dog (Canis lupus familiaris) TRDJ
Gene table: dog (Canis lupus familiaris) TRDC
Potential germline repertoire: dog (Canis lupus familiaris) TRDV, TRDD and TRDJ genes on chromosome 8
Locus description: dog (Canis lupus familiaris) TRA