Dog (Canis lupus familiaris) TRG locus on chromosome 18
- The dog (Canis lupus familiaris) TRG locus is on
chromosome 18. The orientation of the locus is reverse (FWD).
- The dog (Canis lupus familiaris) TRG locus spans 448 kilobases (kb),
from 10 kb upstream of the most 5' gene in the locus, TRGV1-1 (P), to 10 kb
downstream of the most 3' gene in the locus, TRGC8 (F).
The Locus representation
encompasses 550 kb including the 5' borne AMPH and the 3' borne STARD3NL.
- The dog (Canis lupus familiaris) TRG locus consists
of 16 TRGV genes belonging to 7 TRGV subgroups, 16 TRGJ genes belonging to 8 TRGJ sets, and
8 TRGC genes [1-3].
- The TRGV genes span 207 kilobases (kb), the TRGJ genes span 72 kilobases (kb) and
the TRGC genes span 168 kilobases (kb).
Clusters
- The TRGV, TRGJ and TRGC genes are localized in 8 V-J-C-CLUSTER:
- the first V-J-C-CLUSTER in 5', includes 1 TRGV gene (pseudogene), 2 TRGJ genes (1 gene is
ORF, 1 gene is pseudogene) and 1 TRGC gene (ORF).
- the second V-J-C-CLUSTER, includes 2 TRGV genes (1 gene is functional, 1 gene is pseudogene), 2 TRGJ genes (1 gene is
functional, 1 gene is pseudogene) and 1 TRGC gene (functional).
- the third V-J-C-CLUSTER, includes 2 TRGV genes (1 genes is functional, 1 gene is pseudogene), 2 TRGJ genes (1 gene is
ORF, 1 gene is pseudogene) and 1 TRGC gene (functional).
- the fourth V-J-C-CLUSTER, includes 2 TRGV genes (1 gene is functional, 1 gene is pseudogene), 2 TRGJ genes (1 gene is
functional, 1 gene is pseudogene) and 1 TRGC gene (functional).
- the fifth V-J-C-CLUSTER, includes 3 TRGV genes (1 gene is functional, 1 gene is ORF, 1 gene is pseudogene), 2 TRGJ genes (1 gene is functional, 1 gene is ORF) and 1 TRGC gene (functional).
- the sixth V-J-C-CLUSTER, includes 2 TRGV genes (1 gene is functional, 1 gene is pseudogene), 2 TRGJ genes (1 gene is
functional, 1 gene is ORF) and 1 TRGC gene (pseudogene).
- the seventh V-J-C-CLUSTER, includes 3 TRGV genes (2 genes are functional, 1 gene is pseudogene), 2 TRGJ genes (1 gene is
functional, 1 gene is pseudogene) and 1 TRGC gene (functional).
- the eighth V-J-C-CLUSTER in 3', includes 1 TRGV gene (pseudogene), 2 TRGJ genes (1 gene is
functional, 1 gene is pseudogene) and 1 TRGC gene (functional).
- Created:
- 22/03/2018
- Last updated:
- Wednesday, 12-Jun-2024 16:02:36 CEST
- Author:
- Géraldine Folch
