Human (Homo sapiens) TRB locus on chromosome 7
- The human (Homo sapiens) TRB locus is on chromosome 7q34.
The orientation of the locus is forward (FWD).
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The human (Homo sapiens) TRB locus spans 582 kilobases (kb), from 10 kb upstream of the most 5' gene in the locus, TRBV1 (P),
to 10 kb downstream of the most 3' gene in the locus, TRBV30 (F).
- The human (Homo sapiens) TRB locus consists of 86 genes:
68 TRBV belonging to 30 subgroups and 3 clans, 2 TRBD, 14 TRBJ and 2 TRBC.
- The TRBV genes span 532 kilobases (kb), the TRBD genes span 25 kilobases (kb), the TRBJ genes span 7 kilobases (kb)
and the TRBC gene spans 12 kilobases (kb).
Clusters
- The TRBV genes are localized in 2 V-CLUSTER:
- The 5' V-CLUSTER, classically in 5' of the TRBD, TRBJ and
TRBC, includes 67 TRBV genes belonging to 29 subgroups and 3 clans.
- The 3' V-CLUSTER, downstream of the TRBC in inverted
orientation, includes 1 TRBV gene.
- The TRBD, TRBJ and TRBC genes are localized in two
D-J-C-CLUSTER between the 5' V-CLUSTER and the 3' V-CLUSTER:
- The first D-J-C-CLUSTER, in 3' of the 5' V-CLUSTER, includes 1 TRBD gene (functional),
6 TRBJ genes (functional) and 1 TRBC gene (functional).
The most C-proximal TRBJ gene, TRBJ1-6, being localized at 2654 kilobases in 5' of TRBC1.
- The second D-J-C-CLUSTER, in 5' of the 3' V-CLUSTER, includes 1 TRBD gene (functional),
8 TRBJ genes (7 genes are functional and 1 gene is ORF) and 1 TRBC gene (functional).
The most C-proximal TRBJ gene, TRBJ2-7, being localized at 3541 kilobases in 5' of TRBC2.
Bornes of the human (Homo sapiens) TRB locus on chromosome 7
- MOXD2 (5' borne) has been identified 52 kb upstream of TRBV1, the most 5' gene in the locus and PRSS58 (serine protease 58, trypsinogen-like TRYX3, TRY1) (previous 5' borne) has been identified 41 kb upstream of TRBV1.
- EPHB6 (3' borne) has been identified 41 kb downstream of TRBV30, the most 3' gene in the locus.
- Created:
- 07/11/2025
- Last updated:
- 12/11/2025 20:11
- Author:
- Ambre Petit
