Sheep (Ovis aries) TRB locus
- The sheep (Ovis aries) TRB locus is on chromosome 4.
The orientation of the locus is forward (FWD).
- The sheep (Ovis aries) TRB locus spans 500 kilobases (kb),
from 10 kb upstream of the most 5' gene in the locus, TRBV1 (F), to 10 kb
downstream of the most 3' gene in the locus, TRBV30 (F).
The Locus representation
encompasses 570 kb including the 5' borne MOXD2 and the 3' borne EPHB6.
- The sheep (Ovis aries) TRB locus consists
of 94 TRBV genes belonging to 26 TRBV subgroups, 3 TRBD genes
belonging to 3 TRBD sets, 19 TRBJ genes belonging to 3 TRBJ sets, and
3 TRBC genes.
- The TRBV genes span 448
kilobases (kb), the TRBD genes span 7033
bases (b), the TRBJ genes span 9687
bases (b) and the TRBC genes span 18
kilobases (kb).
Clusters
- The TRBV genes are localized in 2 V-CLUSTER:
- the 5' V-CLUSTER, classically in 5' of the TRBD, TRBJ and
TRBC, includes 93 TRBV genes belonging to 25 subgroups (45 genes
are functional, 12 genes are ORF and 36 genes are pseudogenes).
- the 3' V-CLUSTER, downstream of the TRBC in inverted
orientation, includes 1 TRBV gene (functional).
- The TRBD, TRBJ and TRBC genes are localized in three
D-J-C-CLUSTER between the 5' V-CLUSTER and the 3' V-CLUSTER:
- the first D-J-C-CLUSTER, in 3' of the 5' V-CLUSTER,
includes 1 TRBD gene (functional), 6 TRBJ genes (5 genes are
functional and 1 gene is ORF) and 1 TRBC gene (functional).
The most C-proximal TRBJ gene, TRBJ1-6, being localized at
2.686 kilobases in 5' of TRBC1.
- the second D-J-C-CLUSTER, between the first and the third D-J-C-CLUSTER,
includes 1 TRBD gene (functional), 6 TRBJ genes (5 genes are
functional and 1 gene is pseudogene) and 1 TRBC gene (functional).
The most C-proximal TRBJ gene, TRBJ3-5, being localized at
3.705 kilobases in 5' of TRBC3.
- the third D-J-C-CLUSTER, in 5' of the 3' V-CLUSTER,
includes 1 TRBD gene (functional), 7 TRBJ genes (functional)
and 1 TRBC gene (functional). The most C-proximal TRBJ gene,
TRBJ2-7, being localized at 2.603 kilobases in 5' of TRBC2.
Bornes of the sheep (Ovis aries) TRB locus
- MOXD2 (5' borne) has been identified 6 kb upstream of
TRBV1, the most 5' gene in the locus.
- EPHB6 (3' borne) has been identified 53 kb downstream of
TRBV30, the most 3' gene in the locus.
- Created:
- 02/04/2019
- Last updated:
- Friday, 22-Sep-2023 18:22:19 CEST
- Author:
- Perrine Pégorier
