IMGT Repertoire (IG and TR)

Potential germline repertoire: dog (Canis lupus familiaris) TRBV, TRBD and TRBJ genes on chromosome 16

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Dog (Canis lupus familiaris) TRBV genes

The dog (Canis lupus familiaris) TRB locus on chromosome 16 comprises 36 TRBV genes belonging to 25 TRBV subgroups:

• 22 FUNCTIONAL
• 1 ORF (Open Reading Frame)
• 13 PSEUDOGENE

The TRBV genes are localized in 2 V-CLUSTER:

• the 5' V-CLUSTER, classically in 5' of the TRBD, TRBJ and TRBC, includes 35 TRBV genes belonging to 24 subgroups (21 genes are functional, 1 gene is ORF and 13 genes are pseudogenes)
• the 3' V-CLUSTER, downstream of the TRBC in inverted orientation, includes 1 TRBV gene (functional)

Localization of the V-CLUSTER in the locus	IMGT subgroup	Functional	ORF	Pseudogene	Total
5' V-CLUSTER	TRBV1	1	0	0	1
	TRBV2	0	0	3 (0:3)	3
	TRBV3	2	0	1 (1:0)	3
	TRBV4	4	0	0	4
	TRBV5	2	0	2 (0:2)	4
	TRBV6	0	0	1 (0:1)	1
	TRBV7	1	0	0	1
	TRBV8	0	0	1 (0:1)	1
	TRBV10	1	0	0	1
	TRBV11	0	0	1 (0:1)	1
	TRBV12	1	0	1 (1:0)	2
	TRBV15	0	1	0	1
	TRBV16	1	0	0	1
	TRBV18	1	0	0	1
	TRBV19	0	0	1 (1:0)	1
	TRBV20	1	0	0	1
	TRBV21	0	0	1 (1:0)	1
	TRBV22	1	0	0	1
	TRBV24	1	0	0	1
	TRBV25	1	0	0	1
	TRBV26	1	0	0	1
	TRBV27	0	0	1 (1:0)	1
	TRBV28	1	0	0	1
	TRBV29	1	0	0	1
3' V-CLUSTER	TRBV30	1	0	0	1
Total		22	1	13	36

In the column 'Pseudogene', the number of pseudogenes with V-REGION in-frame and the number of pseudogenes with frameshift(s) are shown separated by two dots, between parentheses.

Dog (Canis lupus familiaris) TRBD genes

The dog (Canis lupus familiaris) TRB locus on chromosome 16 comprises 2 TRBD genes belonging to 2 TRBD set:

• 2 FUNCTIONAL

IMGT group	IMGT set or subgroup (if any)	Functional	ORF	Pseudogene	Total
TRBD	TRBD1	1	0	0	1
	TRBD2	1	0	0	1
Total		2	0	0	2

Dog (Canis lupus familiaris) TRBJ genes

The dog (Canis lupus familiaris) TRB locus on chromosome 16 comprises 12 TRBJ genes belonging to 2 TRBJ set:

• 9 FUNCTIONAL
• 2 ORF (Open Reading Frame)
• 1 PSEUDOGENE

IMGT group	IMGT set or subgroup (if any)	Functional	ORF	Pseudogene	Total
TRBJ	TRBJ1	4	1	1	6
	TRBJ2	5	1	0	6
Total		9	2	1	12

More information:
Gene table: dog (Canis lupus familiaris) TRBV
Gene table: dog (Canis lupus familiaris) TRBD
Gene table: dog (Canis lupus familiaris) TRBJ
Locus description: dog (Canis lupus familiaris) TRB

Created: 09/10/2017
Last updated: Friday, 22-Sep-2023 18:22:30 CEST
Author: Perrine Pégorier
Editor: Chantal Ginestoux

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