Dog (Canis lupus familiaris) TRB locus on chromosome 16
- The dog (Canis lupus familiaris) TRB locus is on chromosome 16.
The orientation of the locus is reverse (REV).
- The dog (Canis lupus familiaris) TRB locus spans 290 kilobases (kb),
from 10 kb upstream of the most 5' gene in the locus, TRBV1 (F), to 10 kb
downstream of the most 3' gene in the locus, TRBV30 (F).
The Locus representation
encompasses 350 kb including the 5' borne MOXD2 and the 3' borne EPHB6.
- The dog (Canis lupus familiaris) TRB locus consists
of 36 TRBV genes belonging to 25 TRBV subgroups, 2 TRBD genes
belonging to 2 TRBD set, 12 TRBJ genes belonging to 2 TRBJ set, and
2 TRBC genes [1-2-3].
- The TRBV genes span 243
kilobases (kb), the TRBD genes span 9926 bases
(b), the TRBJ genes span 6728 bases (b) and
the TRBC genes span 11609 bases (b).
Clusters
- The TRBV genes are localized in 2 V-CLUSTER:
- the 5' V-CLUSTER, classically in 5' of the TRBD, TRBJ and
TRBC, includes 35 TRBV genes belonging to 24 subgroups (21 genes
are functional, 1 gene is ORF and 13 genes are pseudogenes).
- the 3' V-CLUSTER, downstream of the TRBC in inverted
orientation, includes 1 TRBV gene (functional).
- The TRBD, TRBJ and TRBC genes are localized in two
D-J-C-CLUSTER between the 5' V-CLUSTER and the 3' V-CLUSTER:
- the first D-J-C-CLUSTER, in 3' of the 5' V-CLUSTER,
includes 1 TRBD gene (functional), 6 TRBJ genes (4 genes are
functional, 1 gene is ORF and 1 gene is pseudogene) and 1 TRBC
gene (functional). The most C-proximal TRBJ gene, TRBJ1-6,
being localized at 2.420 kilobases in 5' of TRBC1.
- the second D-J-C-CLUSTER, in 5' of the 3' V-CLUSTER,
includes 1 TRBD gene (functional), 6 TRBJ genes (5 genes are
functional and 1 gene is ORF) and 1 TRBC gene (functional).
The most C-proximal TRBJ gene, TRBJ2-6, being localized at 3.118
kilobases in 5' of TRBC2.
Bornes of the dog (Canis lupus familiaris) TRB locus
- MOXD2 (5' borne) has been identified 4 kb upstream of
TRBV1, the most 5' gene in the locus.
- EPHB6 (3' borne) has been identified 36 kb downstream of
TRBV30, the most 3' gene in the locus.
- Created:
- 21/12/2017
- Last updated:
- Wednesday, 12-Jun-2024 16:02:36 CEST
- Author:
- Perrine Pégorier
