Particularities in protein designations: Human immunoglobulins: New and Newm

Click here to see Part 2 - Protein display showing the discrepancies between sequences.

Part 1 - Discrepancies between protein names in publications and databases.

Click here to see Protein New

Click on an accession number to get the sequence and additional information.

Protein Newm (human (lambda) IgG1 myeloma protein) (1)
Chain Domain Protein name as mentioned in Databases Accession number Discrepancies between amino acid sequences in databases and localization of the exceptional deletion of the lambda chain
publications databases
1 34 35 66 to 72 85 IMGT unique numbering for V-REGIONs
1 31 32 50 to 56 69 Kabat numbering
Lambda V l chain Newm from IgG
New [1]
Fab New [2] 		Ig l chain V-I region (Newm) GenPept L1HUNM
g69828 		Q N H deletion of 7 aa S  
Fab New [3] Fab New l light chain AAB24270
g260395 		Z H N deletion of 7 aa T  
l chain Newm from IgG
New [1] 		NEWM Kabat 007549 PCA(2) N H deletion of 7 aa S  
l chain Newm from IgG New[1]
Fab New [2] 		Ig l chain V-I region (Newm) PIR L1HUNM
A01968		 Q N H deletion of 7 aa S  
SWISS - PROT P01703 Q N H deletion of 7 aa S  
Fab New [2] Fab' New PDB 7fab A H N deletion of 7 aa T  
Fab Newm IMGT/3Dstructure-DB 7fab
Chain Domain Protein name as mentioned in Databases Accession number Discrepancies between amino acid sequences in databases
publications databases
12 13 100 105 IMGT unique numbering for C-DOMAINs.
123 124 190 195 Kabat numbering
Lambda C - - GenPept -  
l chain Newm from IgG
New [1] 		NEWM Kabat 013784 Z Z K Z  
Newm PIR L2HU
A90375		 E E R Q  
- - SWISS - PROT -  
Chain Domain Protein name as mentioned in Databases Accession number Discrepancies between amino acid sequences in databases (3) 
publications databases
1 5 6 28 29 31 32 33 39 59 62 66 67 68 69 70 74 81 114
1 5 6 27 28 30 31 32 34 54 57 58 59 60 61 62 65 72 100
Heavy V Fab New [2]
IgG New[4] 		Ig heavy chain V-II region (Newm) GenPept G1HUNM
g69974		 Q E Q S T S N D Y H S D D T T P S D C
IgG New [4] Fab' New[5] NEWM Kabat 000838 PCA(2) Z Z - - - - - - - - - - - - - - - -
Fab New [2] Fab' New PDB 7fab A - - T S D D Y W T T L L D P S G N G
Fab Newm IMGT/3Dstructure-DB 7fab
Heavy C (4) - - - -  

IMGT notes:
(1) The designation Newm has been proposed to be used for the lambda light chain from the human IgG1 myeloma protein [1-5], to avoid confusion with the human New Bence Jones protein [6], that has been sequenced before Newm [1]. In IMGT, Newm refers both to the heavy chain and to the complete IgG1 myeloma protein.
(2) PCA: Pyrrolidone Carboxylic Acid.
(3) IMGT unique numbering for V-DOMAINs is on upper line and Kabat numbering on lower line.
Position 114 belongs to the CDR3-IMGT of the V-D-J-JUNCTION (according to the IMGT unique numbering for V-DOMAINs).
Dashes indicate identical amino acids compared to the GenPept sequence.
(4) Not sequenced.

References:
[1] Chen, B.L. and Poljak, R.J., Biochemistry, 13, 1295-1302 (1974). PMID: 4814727
[2] Saul, F.A., Amzel, L.M. and Poljak, R.J., J. Biol. Chem., 253, 585-597 (1978). PMID: 618887
[3] Saul, F.A. and Poljak, R.J., Proteins, 14, 363-371 (1992). MEDLINE:PMID: 93066153
[4] Poljak, R.J. et al., Biochemistry, 16, 3412-3420 (1977). PMID: 407927
[5] Poljak, R.J. et al., Proc. Natl. Acad. Sci. USA, 71, 3440-3444 (1974). PMID: 4215080
[6] Langer, B. et al., Hoppe-Seyler's Z. Physiol. Chem., 349, 945-951 (1968). PMID: 4177823

Created: 03/04/2001
Last updated: Wednesday, 12-Jun-2024 16:02:41 CEST
Author: Lisa Truong