The orientation of the human (Homo sapiens) TRA/TRD locus on the chromosome 14 (14q11.2) is forward (FWD).
Legend:
Colors are according to IMGT color menu for genes.
The boxes representing the genes are not to scale. Exons are not shown.
A double slash // indicates a gap in genome assembly. Distances in bp (base pair) or in kb (kilobase) associated with a double slash are taken
into account in the length of the lines and included in the numbers displayed at the right end of the lines.
A dotted line ... indicates the distance in kb (kilobase) between the locus and its bornes (5' borne and the most 5' gene in the locus and/or 3'
borne and the most 3' gene in the locus) on the top and bottom lines, respectively. These distances are not represented at scale and/or are not
included in IMGT-LOCUS-UNIT and may not be included in the numbers displayed at the right ends of these two lines
.
A small arrow shows a gene (TRDV3) whose polarity is opposite to that of the TRD D-J-C-CLUSTER.
Bornes of the human (Homo sapiens) TRA/TRD locus
• No 5' borne conserved between species has been identified upstream of TRAV1-1 (F), the most 5' gene in the locus.
• DAD1 (defender against cell death) (3' borne) has been identified 13 kb downstream of TRAC (F), the most 3' gene in the locus.
Updates
• Update of the functionality for TRAV8-7 (P instead of ORF) (15/07/19).
• Addition of the 3' borne DAD1 (F), of the functionality P for TRAV35 and of 7 TRAV P, from 5' to 3': TRAVA, TRAVB, TRAV14-1, TRAV11-1, TRAVC, TRAV8-6-1 and TRAV46 (07/11/19).
Gene localization is according to data from
IMGT/LocusView.
This locus representation with only the functional genes is used with IMGT/GeneFrequency.
* When needed, indicate the presence of allele(s) with another functionality: see above human (Homo sapiens) TRA/TRD locus