IMGT Repertoire (IG and TR)

Locus representation: Human (Homo sapiens) TRG

Citing this page:
Lefranc, M.-P. et al., Eur. J. Immunol., 19, 989-994 (1989) PMID: 2526744
Lefranc, M.-P. and Lefranc, G., The T cell receptor FactsBook, Academic Press, London, 398 pages (2001) IMGT/LIGM-DB: IMGT000011 (582960 bp), human (Homo sapiens) TRG locus.

Human (Homo sapiens) TRG locus on chromosome 7 (7p14)

The orientation of the human (Homo sapiens) TRG locus on the chromosome 7 (7p14) is reverse (REV).

Locus representation human TRG

Legend:
Colors are according to IMGT color menu for genes.
The boxes representing the genes are not to scale. Exons are not shown.
A double slash // indicates a gap in genome assembly. Distances in bp (base pair) or in kb (kilobase) associated with a double slash are taken into account in the length of the lines and included in the numbers displayed at the right end of the lines.
A dotted line ... indicates the distance in kb (kilobase) between the locus and its bornes (5' borne and the most 5' gene in the locus and/or 3' borne and the most 3' gene in the locus) on the top and bottom lines, respectively. These distances are not represented at scale and/or are not included in IMGT-LOCUS-UNIT and may not be included in the numbers displayed at the right ends of these two lines .

A double arrow indicates insertion/deletion polymorphisms.

Bornes of the human (Homo sapiens) TRG locus

• AMPH (amphiphysin) (5' borne) has been identified 16 kb upstream of TRGV1 (ORF), the most 5' gene in the locus.
• STARD3NL (STARD3 N-terminal like) (3' borne) has been identified 9,4 kb downstream of TRGC2 (F), the most 3' gene in the locus.

Locus representation with only the functional genes: human (Homo sapiens) TRG

Gene localization is according to data from IMGT/LocusView.
This locus representation with only the functional genes is used with IMGT/GeneFrequency.

Locus representation human TRG

* When needed, indicate the presence of allele(s) with another functionality: see above human (Homo sapiens) TRG locus

Zoom for TRGJ genes

zoom

IMGT references:
  1. [1] Lefranc, M.-P. and Lefranc, G., The T cell receptor FactsBook, Academic Press, London, 398 pages (2001).
  2. [2] Lefranc, M.-P., Nomenclature of the human T cell receptor genes, Current Protocols in Immunology, A.1O.1-A.1O.23 (2000).
  3. [3] Lefranc, M.-P. and Rabbitts, T.H., TIBS, 14, 214-218 (1989). PMID:2527426
  4. [4] Lefranc, M.-P. et al., Eur. J. Immunol., 19, 989-994 (1989). PMID:2526744
  5. [5] Lefranc, M.-P. and Rabbitts, T.H., Res. Immunol., 141, 565-577 (1990). PMID:2151348
  6. [6] Lefranc, M.-P. and Rabbitts, T.H., Res. Immunol., 141, 615-618 (1990). PMID:1965674
TRGV genes
  1. [7] Lefranc, M.-P. et al., Cell, 45, 237-246 (1986). PMID:2938743
  2. [8] Forster, A. et al., EMBO J., 6, 1945-1950 (1987). PMID:2820713
  3. [9] Huck, S. et al., EMBO J., 7, 719-726 (1988). PMID:2969332
  4. [10] Zhang, X.M. et al., Eur. J. Immunol., 24, 571-578 (1994). PMID:8125127
  5. [11] Zhang, X.M. et al., Immunogenetics, 43, 196-203 (1996). PMID:8575818
TRGJ genes
  1. [12] Huck, S. and Lefranc, M.-P., FEBS Lett., 224, 291-296 (1987). PMID:2961609
TRGC genes
  1. [13] Lefranc, M.-P. et al., Proc. Natl. Acad. Sci., 83, 9596-9600 (1986). PMID:2879283
  2. [14] Buresi, C. et al., Immunogenetics, 29, 161-172 (1989). PMID:2564370
Silencers and enhancer
  1. [15] Lefranc, M.-P. and Alexandre, D., Eur. J. Immunol., 25, 617-622 (1995). PMID:7875223
RFLP polymorphisms of the TRGV and TRGC genes
  1. [16] Buresi, C. et al., Immunogenetics, 29, 161-172 (1989). PMID:2564370
  2. [17] Ghanem, N. et al., Immunogenetics, 30, 350-360 (1989). PMID:2572547
  3. [18] Ghanem, N. et al., Human Genet., 86, 450-456 (1991). PMID:1673112
Created:
21/07/1995
Last updated:
22/09/2023
Authors:
Anne Bouisson, Géraldine Folch, Nathalie Pallarès, Manuel Ruiz, Christèle Martinez-Jean, Joumana Jabado-Michaloud and Marie-Paule Lefranc