IMGT Repertoire (IG and TR)

Chromosomal localization: human (Homo sapiens) IGK

Citing this page: Lefranc, M.-P., Exp. Clin. Immunogenet., 18, 161-174 (2001). PMID:11549845 pdficon

The human (Homo sapiens) IGK locus is located on chromosome 2 [1,2], on the short arm, at band 2p11.2 [3].

The orientation of the human IGK locus on the chromosome is reverse (REV).
The orientation of the locus has been determined by the analysis of translocations, involving the IGK locus, in leukemia and lymphoma.

A vertical red line indicates the localization of the IGK locus at 2p11.2.
A blue arrow indicates the orientation 5' → 3' of the locus, and the gene group order in the locus. The blue arrow is proportional to the size of the locus, indicated in kilobases (kb). The total number of genes in the locus is shown between parentheses; the lower number (46 genes) correspond to the rare haplotype which only comprises the proximal V-CLUSTER (close to IGKC) [4,5] of 40 IGKV genes, whereas the higher number (82 genes) correspond to the common haplotype which comprise both the distal and the proximal V-CLUSTERs and 76 IGKV genes.

Chromosomal localization human IGK

IMGT references:
  1. [1] Malcolm, S. et al., Proc. Natl. Acad. Sci. USA, 79, 4957-4961 (1982).
  2. [2] Emanuel, B.S. et al., Proc. Natl. Acad. Sci. USA, 81, 2444-2446 (1984).
  3. [3] McBride, O.W. et al., Exp. Med., 155, 1480-90 (1982).
  4. [4] Pargent W. et al., Eur. J. Immunol., 21, 1829-1835 (1991).
  5. [5] Schaible G. et al., Hum. Genet., 91, 261-267. (1993).
Last updated:
Chantal Ginestoux and Marie-Paule Lefranc