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"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

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Click here for Number of genes as deduced by RFLP analysis.

IMGT gene name IMGT allele name Fct Chromosomal localization T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Strain Clone names Exons Accession numbers Positions in the sequence
(C-GENE-UNIT)
Secondary accession numbers Strain Clone names Accession numbers Positions in the sequence
(C-GENE-UNIT)
IGLC1 IGLC1*01 F 16 (13.0 cM) + BALB/c Clambda1 MAP J00587 [1] BALB/c X58411 [3] (7)
C57BL/6J CM001009.3 MAP IMGT000117 208624..208943
IGLC1*02 P (1) 16 (13.0 cM) BALB/c V00814 [4] (1)
IGLC2 IGLC2*01 F 16 (13.0 cM) + BALB/c Clambda2 MAP J00595 [1] J00592 [2]
BALB/c X58414 [3] (5)
C57BL/6J CM001009.3 MAP IMGT000117 71843..72159
IGLC3 IGLC3*01 F 16 (13.0 cM) BALB/c Clambda3 MAP J00585 [1] BALB/c X58415 [3]
X58411 [3] (6)
C57BL/6J CM001009.3 MAP IMGT000117 205014..205330
IGLC4 IGLC4*01 P (7) 16 (13.0 cM) BALB/c J558/eCL4 (3) MAP X58416 [3] BALB/c M315/eCL4 MAP X58410 [3] (4)
Clambda4 MAP J00598 [1] (2)
X58414 [3] (5)
IGLC4*02 F 16 (13.0 cM) C57BL/6J CM001009.3 MAP IMGT000117 75383..75696
IGLC5 (8) 16 (13.0 cM)

MAP: Mapped reference sequences.

IMGT notes:
  1. (1) Partial C-REGION pseudogene due to a STOP-CODON at position 23 (may be due to a sequencing error). ACT position 43, 44, 45, GAG position 46, 47, 48, A position 69 and A position 132 are probably sequencing errors.
  2. (2) Conflict with X58416 and X58410 due to INSERTION of g (173) and c (329), and DELETION of c (325), which may be sequencing errors [3].
  3. (3) From B cell line J558.
  4. (4) From B cell line MOPC 315.
  5. (5) X58414 contains the IGLJ2, IGLC2, IGLJ4 and IGLC4 genes from the BALB/c MOPC 315 B cell line. Originally these genes were submitted independently (X58414 being the IGLC2 accession number). Secondary accession numbers of X58414 correspond to the primary accession numbers of IGLJ2 (X58420/M28321), IGLJ4 (X58422/M28324) and IGLC4 (X58416) from MOPC 315. The secondary accession number X58410/M28329 corresponds to the primary accession number of IGLC4 from BALB/c J 558 cell line, whose sequence is identical to that of MOPC 315.
  6. (6) X58411 contains the IGLJ1, IGLC1, IGLJ3 and IGLC3 genes from the BALB/c MOPC 315 B cell line. Originally these genes were submitted independently (X58411 being the IGLC1 accession number). Secondary accession numbers of X58411 correspond to the primary accession numbers of IGLJ1 (X58419/M28320), IGLJ3 (X58421/M28322/M28323) and IGLC3 (X58415/M28327) from MOPC 315.
  7. (7) DELETION of 1 bp at position 119 in codon 40 leading to a frameshift.
  8. (8) Absent in BALB/c.
IMGT references:
  1. [1] Selsing E. et al., Proc. Natl. Acad. Sci. USA, 79, 4681-4685 (1982). PMID:6812053
  2. [2] Wu G. et al., Cell, 33, 77-83 (1983). PMID:6432336
  3. [3] Weiss S. and Wu GE, EMBO J., 6, 927-937 (1987). PMID:3109891
  4. [4] Bernard O. et al., Cell, 15, 1133-1144 (1978). PMID:103630
Created:
03/11/1999
Last updated:
05/10/2022
Authors:
Dominique Scaviner, Delphine Guiraudou and Yascim Kamel