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"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

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IMGT gene name IMGT allele name Fct T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Strain Clone names Exons Accession numbers Positions in the sequence Secondary accession numbers Strain Clone names Accession numbers Positions in the sequence
IGHG1 (1) IGHG1*01 (F) CH1 AJ421266 c
H AJ421266 c
CH2 AJ421266 c
CH3 (including CHS) AJ421266 c
IGHG2 (2) IGHG2*01 F ch51666 CH1 (2) AJ131945 (3)
H AJ131945
CH2 AJ131945
CH3 (including CHS) AJ131945
M1 AJ131945
M2 AJ131945
IGHG3 (2) IGHG3*01 (F) CH1 (2)
H Z48947 c (s)
CH2 Z48947 c (s)
CH3 (including CHS) Z48947 c (s)

c: cDNA sequence.
(s) Transcript of a secreted chain.

IMGT notes:
  1. (1) The IGHG1 gene encodes a classical gamma 1 chain, part of a conventional tetrameric IgG1.
  2. (2) The IGHG2 gene and IGHG3 gene encode a gamma 2 chain and a gamma 3 chain, respectively, which are both characterized by the absence of the CH1 domain due to a splicing defect of the CH1 exon.
  3. (3) IGHV genes expressed with the gamma2 and gamma3 chains comprise genes belonging to the IGHV1 second set (see Germline gene table).
IMGT references:
  1. [1] Nguyen V.K. et al., Mol. Immunol., 36, 515-524 (1999). PMID:10475606
  2. [2] Atarhouch T. et al., Unpublished.
  3. [3] Nguyen V.K. et al., Immunogenetics, 54, 39-47 (2002). PMID:11976790
Last updated:
Christèle Martinez-Jean, Joumana Jabado-Michaloud