IMGT Repertoire (IG and TR)


Gene table: human (Homo sapiens) IGKV

Citing this page: Barbié, V. and Lefranc, M.-P., Exp. Clin. Immunogenet., 15, 171-183 (1998) PMID: 9813414 pdf UPDATE: Human IGKV (04/2005)

"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

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The 7 human (Homo sapiens) IGKV subgroups belong to three clans (Figure IGKV clans). Clans comprise, respectively:

IGKV gene names are designated by a number for the subgroup, followed by a dash and a number for the localization from 3' to 5' in the locus. The IGKV genes of the distal duplicated V-CLUSTER are designated by the same number as the corresponding genes in the proximal V-CLUSTER, with the letter D added.

IMGT subgroup IMGT gene name IMGT allele name Fct Chromosomal localization R T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Clone names Accession numbers Positions in the sequence
(L-V-GENE-UNIT)		 Secondary accession numbers Clone names Accession numbers Positions in the sequence
(L-V-GENE-UNIT)
IGKV1 IGKV1-5 IGKV1-5*01 F 2p11.2 L12 MAP Z00001 [2] HK102 MAP J00245 [2]
IGKV1-5*02 F 2p11.2 V1 MAP M23851 [12]
IGKV1-5*03 F 2p11.2 + + + L12a MAP X72813 [10]
IGKV1-5*04 F 2p11.2 MAP MW316670 [45][56] 73..578
IGKV1-5*05 F 2p11.2 MAP MW316676 [45][56] 73..578
IGKV1-6 IGKV1-6*01 F 2p11.2 + L11 (Vf) MAP M64858 [26] DPK3 X93621 [6]
IGKV1-6*02 F 2p11.2 MAP KM455558 [43]
IGKV1-8 IGKV1-8*01 F (1) 2p11.2 + L9 (Ve) MAP Z00014 [20] K02097 [20] KM455559 [43]
MW316672 [45][56] 328..827
IGKV1-8*02 F 2p11.2 MAP MW316669 [45][56] 322..827
IGKV1-8*03 F 2p11.2 MAP MW316671 [45][56] 322..827
IGKV1-9 IGKV1-9*01 F (2) 2p11.2 + + L8 (Vd) MAP Z00013 [20] K02096 [20] DPK8 X93626 [6]
IGKV1-12 IGKV1-12*01 F 2p11.2 + + + L5 MAP V01577 [20] Vb MAP K02094 [20]
DPK5 X93623 [6]
IGKV1-12*02 F 2p11.2 (49) (49) L5/19a (V4b; Vb') MAP V01576 [20] (46)
IGKV1-13 IGKV1-13*01 P (3) 2p11.2 L4 (Va) MAP Z00010 [20] K02093 [20] DPK31 X93647 [6]
IGKV1-13*02 F (42) 2p11.2 + + + L4/18a (V4a; Va') MAP Z00006 [20] K02098 [20]
IGKV1-16 IGKV1-16*01 F 2p11.2 + + L1 (HK137; Q14) MAP J00248 [3]
IGKV1-16*02 [F] 2p11.2 FM164406 [42] °
IGKV1-17 IGKV1-17*01 F 2p11.2 + + + A30 MAP X72808 [10] SG3 X92334 [9]
A30 MAP D88254 [39]
IGKV1-17*02 F 2p11.2 + A30 MAP D88255 [39]
IGKV1-17*03 F 2p11.2 MAP KM455566 [43] FM164407 [42] (52) °
IGKV1-22 IGKV1-22*01 P (4) 2p11.2 A25 MAP X71885 [24]
IGKV1-27 IGKV1-27*01 F (5) 2p11.2 + + A20 (Y2) MAP X63398 [15] DPK4 X93622 [6]
IGKV1-32 IGKV1-32*01 P (6) 2p11.2 A15 MAP X71883 [24] DPK35 (48) X93651 [6]
A15a MAP V00560 [2]
HK100 MAP J00250 [2]
J00251 [23]
DPK35 (48) X93651 [6]
IGKV1-33 IGKV1-33*01 F 2p11.2 + + + O18 MAP M64856 [26] 018a MAP M64857 [26]
DPK1 (48) X93620 [6]
IGKV1-35 IGKV1-35*01 P (7) 2p11.2 O16 (Q1) MAP X71890 [24]
IGKV1-35*02 P (7) 2p11.2 O6/16a (V55) MAP Z00005 [12] (46)
IGKV1-37 IGKV1-37*01 ORF (38) 2p11.2 + O14 (Q5) MAP X59316 [18] O4/14a (DILp1) MAP X70466 [17] (46)
DPK11 (48) X93629 [6]
IGKV1-39 IGKV1-39*01 F 2p11.2 + + + O12 MAP X59315 [18] DPK9 (48) X93627 [6]
IGKV1-39*02 P (8) 2p11.2 O12a (V3b) MAP X59318 [18]
IGKV1D-8 IGKV1D-8*01 F 2p11.2 + + L24 (Ve"; V13; Q3) MAP Z00008 [12] L24a MAP X72819 [10]
DPK10 X93628 [6]
IGKV1D-8*02 F 2p11.2 MAP KM455563 [43]
IGKV1D-8*03 F 2p11.2 MAP KM455567 [43]
IGKV1D-8*04 (F) 2p11.2 IGKV1D-8*01_S8780 MAP MK308861 [44] (55) 1..287
IGKV1D-12 IGKV1D-12*01 F 2p11.2 (49) (49) L19 (Vb") MAP X17263 [21] DPK6 X93624 [6]
IGKV1D-12*02 F 2p11.2 (49) (49) L5/19a (V4b; Vb') MAP V01576 [20] (46)
IGKV1D-13 IGKV1D-13*01 F (9) 2p11.2 + + L18 (Va") MAP X17262 [21]
IGKV1D-13*02 F 2p11.2 MAP KM455562 [43]
IGKV1D-16 IGKV1D-16*01 F 2p11.2 L15 (HK166; Q13) MAP K01323 [3] HK134 MAP X92329 [3]
DPK7 X93625 [6]
IGKV1D-16*02 F 2p11.2 L15a (HK101) MAP V00558 [2] J00246 [2] HK146 MAP K01322 [3]
HK189 MAP K01324 [3]
IGKV1D-17 IGKV1D-17*01 F 2p11.2 + L14 (Q4) MAP X63392 [15] DPK2 Z27498 [6]
IGKV1D-22 IGKV1D-22*01 P (4) 2p11.2 A9 MAP X71887 [24]
IGKV1D-27 IGKV1D-27*01 P (10) 2p11.2 A4 (A4a; V52) MAP Z00004 [12] M23848 [12] DPK30 X93646 [6]
IGKV1D-32 IGKV1D-32*01 P (11) 2p11.2 O9 MAP X71896 [34]
IGKV1D-33 IGKV1D-33*01 F 2p11.2 (49) (49) O8 MAP M64855 [26] DPK1 (48) X93620 [6]
IGKV1D-35 IGKV1D-35*01 P (7) 2p11.2 O6 MAP X71894 [34]
IGKV1D-35*02 P (7) 2p11.2 O6/16a (V55) MAP Z00005 [12] (46)
IGKV1D-37 IGKV1D-37*01 ORF (38) 2p11.2 (49) O4 MAP X71893 [24] O4/14a (DILp1) MAP X70466 [17] (46)
DPK11 (48) X93629 [6]
IGKV1D-39 IGKV1D-39*01 F 2p11.2 (49) (49) O2 MAP X59312 [18] DPK9 (48) X93627 [6]
IGKV1D-42 IGKV1D-42*01 ORF (12) 2p11.2 L22 MAP X72816 [10]
IGKV1D-42*02 ORF (12) 2p11.2 MAP KM455560 [43]
IGKV1D-43 IGKV1D-43*01 F 2p11.2 L23 (Q2) MAP X72817 [10] L23a MAP X72818 [10]
IGKV1-NL1 NL IGKV1-NL1*01 F 2p11.2 VkLa Y14865 [40] (44)
IGKV2 IGKV2-4 IGKV2-4*01 P (13) 2p11.2 L13 (Q6) MAP X72814 [10]
IGKV2-10 IGKV2-10*01 P (14) 2p11.2 L7 MAP Z00012 [20] Vc MAP K02095 [20]
IGKV2-14 IGKV2-14*01 P (15) 2p11.2 L3 (Q12) MAP X72810 [10]
IGKV2-18 IGKV2-18*01 P (16) 2p11.2 A29 MAP X63400 [15] DPK27 X93643 [6]
IGKV2-19 IGKV2-19*01 P (17) 2p11.2 A28 MAP X12692 [29]
IGKV2-23 IGKV2-23*01 P (18) 2p11.2 A24 MAP X71885 [24]
IGKV2-24 IGKV2-24*01 F 2p11.2 + + A23 MAP X12684 [29] DPK16 X93633 [6]
IGKV2-26 IGKV2-26*01 P (19) 2p11.2 A21 MAP X71884 [24]
IGKV2-28 IGKV2-28*01 F 2p11.2 + + + A19 (Q7) MAP X63397 [15] DPK15 (48) X93632 [6]
IGKV2-29 IGKV2-29*01 P (20) 2p11.2 + + A18 (A18a) MAP X63396 [15] DPK28 X93644 [6]
IGKV2-29*02 F 2p11.2 A18b U41645 [1]
IGKV2-29*03 F 2p11.2 + + A18c AJ783437 [41] A18d [41]
A18e [41] (45)
IGKV2-30 IGKV2-30*01 F 2p11.2 + + + A17 MAP X63403 [15] DPK18 X93635 [6]
IGKV2-30*02 [F] 2p11.2 FM164408 [42] °
IGKV2-36 IGKV2-36*01 P (21) 2p11.2 O15 (Q8) MAP X71889 [24]
IGKV2-38 IGKV2-38*01 P (22) 2p11.2 O13 MAP X71888 [24]
IGKV2-38*02 P (57) 2p11.2 MAP IMGT000100 [47]
IGKV2-40 IGKV2-40*01 F 2p11.2 + + O11 MAP X59314 [18] DPK13 (48) X93631 [6]
IGKV2-40*02 F 2p11.2 O11a (V3a) MAP X59317 [18]
IGKV2D-10 IGKV2D-10*01 P (14) 2p11.2 L21 (Vc") MAP X17265 [21]
IGKV2D-14 IGKV2D-14*01 P (15) 2p11.2 L17 (Vz") MAP X72811 [10]
IGKV2D-18 IGKV2D-18*01 P (16) 2p11.2 A13 MAP X63395 [15]
IGKV2D-19 IGKV2D-19*01 P (23) 2p11.2 A12 MAP X71882 [24]
IGKV2D-23 IGKV2D-23*01 P (24) 2p11.2 A8 MAP X71887 [24]
IGKV2D-24 IGKV2D-24*01 ORF (41) 2p11.2 A7 MAP X63401 [15] DPK17 X93634 [6]
IGKV2D-26 IGKV2D-26*01 F (25) 2p11.2 cos142 MAP AP001216 A5 MAP X12689 [29]
IGKV2D-26*02 F 2p11.2 DPK14 Z27499 [6]
IGKV2D-26*03 F 2p11.2 KM455565 [43]
IGKV2D-28 IGKV2D-28*01 F 2p11.2 (49) (49) A3 MAP X12691 [29] DPK15 (48) X93632 [6]
RR25gl Z46616 [8]
IGKV2D-29 IGKV2D-29*01 F 2p11.2 + + A2 (A2a) MAP M31952 [25] DPK12 X93630 [6]
IGKV2D-29*02 F (26) 2p11.2 A2c [1] U41644 [1] A2b U41643 [1]
IGKV2D-30 IGKV2D-30*01 F 2p11.2 + A1 MAP X63402 [15] DPK19 X93636 [6]
IGKV2D-36 IGKV2D-36*01 P (21) 2p11.2 O5 MAP X71893 [24]
IGKV2D-38 IGKV2D-38*01 P (22) 2p11.2 O3 MAP X71892 [24]
IGKV2D-40 IGKV2D-40*01 F 2p11.2 (49) O1 MAP X59311 [18] DPK13 (48) X93631 [6]
IGKV3 IGKV3-7 IGKV3-7*01 ORF (27) 2p11.2 L10 (kv3h) MAP X02725 [19]
IGKV3-7*02 ORF (27) 2p11.2 L10a MAP X72812 [10]
IGKV3-7*03 ORF (27) 2p11.2 Vh MAP K02769 [19]
IGKV3-7*04 [ORF] (47) 2p11.2 FM164409 [42] °
IGKV3-11 IGKV3-11*01 F 2p11.2 + + L6 MAP X01668 [19] 38K/L6a X92342 [13]
13K20/13K23 L37726 [11]
IGKV3-11*02 F 2p11.2 Vg (kv3g) MAP K02768 [19]
IGKV3-15 IGKV3-15*01 F 2p11.2 + + + L2 (Humkv328h5; Q11) MAP M23090 [16] DPK21 X93638 [6]
IGKV3-20 IGKV3-20*01 F 2p11.2 + + + A27 MAP X12686 [29] A27a (Humkv325) MAP M15038 [22]
X00900 Humkv321 MAP M15039 [4]
VkRF [33]
Tou-kv325 X56593 [31]
DPK22 X93639 [6]
IGKV3-20*02 F 2p11.2 13K18 L37729 [11]
IGKV3-25 IGKV3-25*01 P (28) 2p11.2 A22 MAP X06583 [35] DPK29 X93645 [6]
IGKV3-31 IGKV3-31*01 P (29) 2p11.2 A16 MAP X71883 [24] A16a (Humkv301) MAP M17765 [33]
A16/O10b (Humkv310) (48) MAP M17764 [33] (46)
IGKV3-34 IGKV3-34*01 P (32) 2p11.2 O17 MAP X71891 [24]
IGKV3D-7 IGKV3D-7*01 F 2p11.2 L25 (V138; Q9) MAP X72820 [10] DPK23 Z27500 [6]
IGKV3D-11 IGKV3D-11*01 F 2p11.2 + L20 (Vg"; kv3g") MAP X17264 [21] 13K11/13K12 L37725 [11]
IGKV3D-11*02 F 2p11.2 MAP KM455561 [43]
IGKV3D-11*03 F 2p11.2 3A7 L19271 [32]
IGKV3D-15 IGKV3D-15*01 F 2p11.2 (49) (49) L16 (Q10) MAP X72815 [10] Humkv328h2/L16a MAP M23089 [16]
Humkv328/L16b MAP M23088 [16]
Humkv31es MAP Y00640 [5]
IGKV3D-15*02 P (33) 2p11.2 L16c (Humkv329) MAP M23091 [16]
IGKV3D-15*03 F 2p11.2 MAP KM455564 [43]
IGKV3D-20 IGKV3D-20*01 F 2p11.2 + A11 MAP X12687 [29] Humkv305/A11a MAP M14507 [4]
DPK20 X93637 [6]
IGKV3D-20*02 ORF (53) 2p11.2 3A9 L19272 [32] (54)
IGKV3D-25 IGKV3D-25*01 P (28) 2p11.2 A6 MAP X71886 [24]
IGKV3D-31 IGKV3D-31*01 P (34) 2p11.2 O10 MAP X71896 [34]
IGKV3D-31*02 P (30) 2p11.2 MAP IMGT000100 [47] A16/O10b (Humkv310) MAP M17764 [33] (46)
IGKV3D-34 IGKV3D-34*01 P (35) 2p11.2 O7 MAP X71895 [34]
IGKV4 IGKV4-1 IGKV4-1*01 F 2p11.2 + + + B3 MAP Z00023 [14] VkIV-GL S56916 [30]
FSA10gl Z46615 [8]
DPK24 X93640 [6]
HSIGKVZM L33853 [7]
AF017732 [37] (39)
IGKV4-1*02 F 2p11.2 MAP MW316673 [45][56] 309..920
IGKV5 IGKV5-2 IGKV5-2*01 F 2p11.2 + + B2 (EV15) MAP X02485 [27] AF017732 [37] (40)
IGKV6 IGKV6-21 IGKV6-21*01 F (50) 2p11.2 + A26 MAP X63399 [15] DPK26 (48) X93642 [6]
IGKV6-21*02 F 2p11.2 MAP KM455568 [43]
IGKV6D-21 IGKV6D-21*01 F (51) 2p11.2 (49) A10 MAP X12683 [28] DPK26 (48) X93642 [6]
HSIGKAU M27750 [28]
IGKV6D-21*02 F 2p11.2 MAP KM455569 [43]
IGKV6D-41 IGKV6D-41*01 ORF (36) 2p11.2 HSIGKAV M27751 [28] (43) DPK25 X93641 [6]
IGKV7 IGKV7-3 IGKV7-3*01 P (37) 2p11.2 B1 MAP X12682 [36] AF017732 [37]

°: DNA genomic sequence, but not known to be rearranged or germline.
NL: Not Localized in the locus.
MAP: Mapped reference sequences.

IMGT notes:
  1. (1) Based on a 21 bp DELETION starting at nucleotide 4 of DECAMER [11] (https://www.imgt.org/IMGTrepertoire/Regulation/promoters/human/IGK/IGKV/Hu_IGKVpromoters.html), the IGKV1-8 functionality was initially defined as "ORF". However the identification of several transcripts indicated that the IGKV1-8 gene is functional (Stamatopoulos K., Belessi C. and Lefranc M. P. 10/10/2007). As the deletion is not observed in KM455559, the 21 bp deletion in Z00014 may correspond to an artefact or to a promoter polymorphism of IGHV8*01.
  2. (2) TTTGCTT instead of TTTGCAT in the core sequence of the DECAMER element [11], but transcript found [8].
  3. (3) CONSERVED-TRP replaced by a STOP-CODON in FR2-IMGT, and non canonical V-HEPTAMER: CATAGTG instead of CACAGTG [11].
  4. (4) STOP-CODONs in FR2-IMGT, INSERTION of 4 bp at position 72 leading to a frameshift in FR3-IMGT [11].
  5. (5) Non canonical V-HEPTAMER: CACTGTG instead of CACAGTG [33], but rearrangement products and productive cDNA found ([8] and see IMGT/GENE-DB).
  6. (6) DELETION of 2 bp at position 17 and INSERTION of 1 bp at position 27/28, 1 bp at position 87/88, and 3 bp at position 85, leading to frameshifts [11]
  7. (7) DELETION of nucleotide 4, and INSERTION of 1 bp at position 15/16. Defective DONOR-SPLICE [11].
  8. (8) STOP-CODON in L-PART1 [11].
  9. (9) IGKV1D-13*01, initially considered as an ORF, due to a non canonical V-HEPTAMER: CATAGTG instead of CACAGTG [11], has been found rearranged and transcribed in a 'productive' sequence (DQ101035). The sequence was obtained from a CLL case expressing kappa light chain isotype (by flow); this case also carried a non-productive, non-transcribed rearranged of the IGKV2-29*01 pseudogene. On these grounds, the IGKV1D-13*01 rearrangement was considered as expressed. (message from K. Stamatopoulous and C. Belessi to M.-P. Lefranc, 07/04/2008).
  10. (10) INSERTION of 1 bp at position 57 in FR3-IMGT, leading to a frameshift [11].
  11. (11) DELETION of 2 bp at position 17, INSERTION of 1 bp between codons 27/28, INSERTION of 3 bp in codon 85, INSERTION of 1 bp between codons 87/88 [11].
  12. (12) TTTGCTT instead of TTTGCAT in the core sequence of the DECAMER, and altered V-HEPTAMER: CACAGGG instead of CACAGTG [11].
  13. (13) No INIT-CODON: ATG replaced by GTG [11].
  14. (14) DELETION of 1 bp at position 74 leading to a frameshift, no INIT-CODON: ATG replaced by GTG, and non canonical ACCEPTOR-SPLICE [11].
  15. (15) No INIT-CODON: ATG replaced by GTG , CT instead of GT in ACCEPTOR_SPLICE, and DELETION of 1 bp at position 4 leading to a frameshift, and non canonical V-HEPTAMER [11].
  16. (16) No INIT-CODON: ATG replaced by ATA [11].
  17. (17) No Vk-gene related sequence was found upstream of codon 12, 5' part of V-REGION truncated [11].
  18. (18) V-EXON consists of 2 parts, separated by 180 bp that show no homology to Ig genes. STOP-CODON at position 35, and no INIT-CODON: ATG replaced by GTG [11].
  19. (19) Frameshift in FR2-IMGT due to 1 bp INSERTION at position 39, and non canonical V-NONAMER [11].
  20. (20) STOP-CODON at position 88 in FR3-IMGT [11].
  21. (21) STOP-CODONs in V-REGION, V-REGION truncated: breakoff of homology before codon 15 and after codon 87 [11].
  22. (22) STOP-CODONs in V-REGION, and breakoff of homology before codon 21, and STOP-CODON in V-REGION [11].
  23. (23) No Vk-gene related sequence was found upstream of codon 12, 5' part of V-REGION truncated [11].
  24. (24) V-EXON consists of 2 parts, separated by 180 bp that show no homology to Ig genes, STOP-CODON in FR2-IMGT, and no INIT-CODON [11].
  25. (25) INSERTION of 1 bp in codon 45 (134^135>ins^a) and DELETION of 1 bp in codon 51 (g153>del) [11]. The insertion in codon 45 leads to a frameshift but the normal reading frame is reestablished by the deletion in codon 51. The resulting sequence shows six amino acid changes from codon 46 to 51 in the FR2-IMGT. The frameshift originally described in FR1-IMGT [13] has not been confirmed.
  26. (26) IGKV2D-29*02, initially considered as an ORF due to a non canonical V-HEPTAMER: CACAGAG instead of CACAGTG, has been found rearranged and transcribed in a 'productive' sequence (DQ101097).
  27. (27) GG instead of AG in the ACCEPTOR_SPLICE [11].
  28. (28) Heavily mutated, insertion of 1.2 kb in V-INTRON. INSERTION of: 3 bp in codon -14/13, 7 bp in codon 81, and DELETION of: 2 bp in codon 27A, 24 bp from codon 56 to 65, 1 bp in codon 83 [11].
  29. (29) STOP-CODON in L-PART1, and DELETION of 2 bp in codon 6 leading to a frameshift [11].
  30. (30) STOP-CODON in L-PART1, frameshift in V-REGION: deletion of 2 nt in FR1-IMGT [33].
  31. (31) DELETION of 2 bp at position 6, leading to a frameshift [11].
  32. (32) STOP-CODON in FR1-IMGT and FR2-IMGT at positions 23 and 38, INSERTION of 1 bp at position 85/86 [11].
  33. (33) STOP-CODON in CDR3 in codon 94 [11].
  34. (34) STOP-CODON in L-PART1, and 2 bp DELETION at position 6 leading to a frameshift [11].
  35. (35) STOP-CODON in FR1-IMGT and FR2-IMGT at positions 23 and 38, INSERTION of 1 bp at position 85/86 [11].
  36. (36) Non canonical V-HEPTAMER: CACTGTG instead of CACAGTG [11].
  37. (37) No INIT-CODON: ATG replaced by ATA[11].
  38. (38) IGKV2nd-CYS replaced by a Glycine in FR3-IMGT.
  39. (39) IGKV4-1 is in an inverted orientation of transcription.
  40. (40) IGKV5-2 is in an inverted orientation of transcription.
  41. (41) IGKV1st-CYS replaced by a Phenylalanine in FR1-IMGT.
  42. (42) IGKV1-13*02, initially considered as an ORF, has been found rearranged and expressed in a functional anti-TPO sequence (clone TR1.9) (L12099) [38] (N. Chapal, S. Roux, T. Chardes and M.-P. Lefranc, comment, 9/11/2000). The Fab of that clone has been crystallized and its 3D structure determined (PDB: 1vge). Note that the four first amino acids ELVM of the V-REGION in L12099 and PDB: 1vge are introduced by the primer. The IgA1 theoretical model (PDB: 1iga) uses the 1vge sequence and structure for the kappa chain (M.-P. Lefranc comments, 28/09/2001)
  43. (43) In EMBL, a new accession number M27751 was created, the original accession number X12688 becoming secondary accession number of M27751.
  44. (44) IGKV1-NL1 is most probably a polymorphic gene by insertion/deletion (found in 12 of 57 (21 %) healthy Caucasians) [40].
  45. (45) The most 3' nucleotide of L-PART2 of A18c is A instead of G. This allele is described as IGKV2-29*03 (L-PART2 g12>a) according to the IMGT numbering for coding regions.
  46. (46) It is not known if this sequence corresponds to that gene or to its duplicate. For that reason, the sequence appears twice in the IMGT/GENE-DB reference sequences.
  47. (47) In the absence of complete sequence the functionality ORF has been assigned based on the other alleles.
  48. (48) As the DPK sequences only contain the V-REGION, some of them could be assigned neither to a gene or its duplicate, nor to any allele of the gene.
  49. (49) Means that the rearrangement, transcript or protein could not be assigned to the gene in the proximal or distal cluster.
  50. (50) IGKV6-21*01, initially considered as an ORF, due to a non canonical V-HEPTAMER: CACTGTG instead of CACAGTG [11], has been found rearranged.
  51. (51) IGKV6D-21*01, initially considered as an ORF, due to a non canonical V-HEPTAMER: CACTGTG instead of CACAGTG [11], has been found rearranged.
  52. (52) The sequence FM164407 previously designated as IGKV1D-17*02 has been shown to correspond to allele IGKV1-17*03 (19/01/2015).
  53. (53) Chimeric sequence between IGKV3D-20 in 5', codons 1 to 106, and IGHV3D-11 in 3', codons 107 to 111, and absence of transcripts.
  54. (54) The sequence L19272 obtained by Polymerase Chain Reaction (PCR) has the features of a chimeric sequence between two different genes belonging to the Homo sapiens IGKV3 subgroup (IGKV3D-20 in 5', codons 1 to 106, and IGHV3D-11*02 in 3', codons 107 to 111). This sequence has been assigned to IGKV3D-20*02 allele with the functionality ORF (chimeric sequence and absence of identified transcripts). This assignment needs to be confirmed by analysis of other genomic and mapped germline clones. (M-P. Lefranc, IMGT-NC, 15/02/15)
  55. (55) Inferred allele: IMGT-NC_Report_2020-3-1120_Homsap_IGKV_IGLV.
  56. (56) IMGT-NC_Report_2021-1-0608_Homsap_IGKV_IGLV.
  57. (57) truncated pseudogene, no L-PART2, several STOP-CODON in V-REGION.
IMGT references:
  1. [1] Atkinson M.J. et al., Immunogenetics, 44, 115-120 (1996). PMID:8662073
  2. [2] Bentley D.L. and Rabbitts T.H., Nature, 288, 730-733 (1980). PMID:6779204
  3. [3] Bentley D.L. and Rabbitts T.H., Cell, 32, 181-189 (1983). PMID:6402305
  4. [4] Chen P.P. et al., Proc. Natl. Acad. Sci. USA, 83, 8318-8322 (1986). PMID:3095834
  5. [5] Chen P.P. et al., J. Exp. Med., 166, 1900-1905 (1987). PMID:3119763
  6. [6] Cox J.P. et al., Eur. J. Immunol., 24, 827-836 (1994). PMID:8149953
  7. [7] Fang Q. et al., Clin. Immunol. Immunopathol., 75, 159-167 (1995). PMID:7704974
  8. [8] Giachino C. et al., J. Exp. Med., 181, 1245-1250 (1995). PMID:7869042
  9. [9] Harada T. et al., J. Immunol., 153, 4806-4815 (1994). PMID:7963546
  10. [10] Huber C. et al., Eur. J. Immunol., 23, 2868-2875 (1993). PMID:8223863
  11. [11] Ichiyoshi Y. et al., J. Immunol., 154, 226-238 (1995). PMID:7995943
  12. [12] Jaenichen H.R. et al., Nucleic Acids Res., 12, 5249-5263 (1984). PMID:6087279
  13. [13] Kimberly V.D. et al., J. Clin. Invest., 87, 1603-1613 (1991). PMID:2022732
  14. [14] Klobeck H.G. et al., Nucleic Acids Res., 13, 6515-6529 (1985). PMID:2997712
  15. [15] Lautner-Rieske A. et al., Eur. J. Immunol., 22, 1023-1029 (1992). PMID:1551402
  16. [16] Liu M.F. et al., J. Immunol., 142, 688-694 (1989). PMID:2492051
  17. [17] Manheimer-Lory A. et al., J. Exp. Med., 174, 1639-1652 (1991). PMID:1660528
  18. [18] Pargent W. et al., Eur. J. Immunol., 21, 1821-1827 (1991). PMID:1907917
  19. [19] Pech M. and Zachau H.G., Nucleic Acids Res., 12, 9229-9236 (1984). PMID:6440122
  20. [20] Pech M. et al., J. Mol. Biol., 176, 189-204 (1984). PMID:6086934
  21. [21] Pech M. et al., J. Mol. Biol., 183, 291-299 (1985). PMID:3927006
  22. [22] Radoux V. et al., J. Exp. Med., 164, 2119-2124 (1986). PMID:3023521
  23. [23] Schäble K.F. and Zachau, H.G., Biol. Chem. Hoppe-Seyler, 374, 1001-1022 (1993). PMID:8292259
  24. [24] Schäble K.F. et al., Biol. Chem. Hoppe-Seyler, 375, 189-199 (1994). PMID:8011175
  25. [25] Scott M.G. et al., J. Immunol., 143, 4110-4116 (1989). PMID:2512350
  26. [26] Scott M.G. et al., J. Immunol., 147, 4007-4013 (1991). PMID:1940382
  27. [27] Stavnezer J. et al., Nucleic Acids Res., 13, 3495-3514 (1985). PMID:3925437
  28. [28] Straubinger B. et al., Biol. Chem. Hoppe-Seyler, 369, 601-607 (1988). PMID:2852016
  29. [29] Straubinger B. et al., J. Mol. Biol., 199, 23-34 (1988). PMID:3351922
  30. [30] Timmers E. et al., Eur. J. Immunol., 23, 619-624 (1993). PMID:8449210
  31. [31] van Es J.H. et al., J. Exp. Med., 173, 461-470 (1991). PMID:1899104
  32. [32] Youngblood K. et al., J. Clin. Invest., 93, 852-861 (1994). PMID:7509350
  33. [33] Chen P.P. et al., J. Immunol., 139, 1727-1733 (1987). PMID:3114376
  34. [34] Schäble K.F., Unpublished.
  35. [35] Straubinger B. et al., Nucleic Acids Res., 15, 9567-9575 (1987). PMID:2825139
  36. [36] Lorenz W. et al., Mol. Immunol., 25, 479-484 (1988). PMID:3137458
  37. [37] Brandt P., Unpublished.
  38. [38] Chazenbalk G.D. et al., J. Clin. Invest., 92, 62-74 (1993). PMID:7686925
  39. [39] Suzuki N. et al., J. Clin. Invest., 98, 1843-1850 (1996). PMID:8878436
  40. [40] Juul L. et al., Immunogenetics, 48, 40-46 (1998). PMID:9601942
  41. [41] Juul L. et al., Tissue Antigens, 49, 595-604 (1997). PMID:9234481
  42. [42] Collins A.M. et al., Unpublished.
  43. [43] Watson C.T. et al., Genes and Immunity, 16, 24-34 (2015). PMID:25338678
  44. [44] Vazquez Bernat N. et al., Front. Immunol., 10, 660-660(2019). PMID:31024532
  45. [45] Mikocziova I., Unpublished.
  46. [46] Ladeana W Hillier et al., Nature, 434(7034), 724-31 (2005). PMID:15815621

Chromosomal orphon set IGKV

IMGT subgroup IMGT gene name IMGT allele name Fct Chromosomal localization R T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Clone names Accession numbers Positions in the sequence Secondary accession numbers Clone names Accession numbers Positions in the sequence
IGKV1 IGKV1/OR-2 IGKV1/OR-2*01 P (2) Outside chr2 [7] Z2 MAP X64640 [7] DPK34 X93650 [2]
IGKV1/OR-3 IGKV1/OR-3*01 P (3) Outside chr2 [7] Z3 MAP X64641 [7] DPK37 Z27501 [2]
IGKV1/OR-4 IGKV1/OR-4*01 P (4) Outside chr2 [7] Z4 MAP X64642 [7]
IGKV1/OR1-1 IGKV1/OR1-1*01 P (5) Chr1 between 1p13 and 1q12 [5] Chr1 MAP M20809 [11]
IGKV1/OR2-0 IGKV1/OR2-0*01 ORF (21) 2p11.2, at, at least, 140 kb in 5' of IGKV3D-7 [1] Z0 MAP Y08392 [1]
IGKV1/OR2-1 IGKV1/OR2-1*01 P (1) 2p11.1 Z1 MAP M20813 [13] RP11-389I13 AC127391
IGKV1/OR2-2 IGKV1/OR2-2*01 P (1) 2p11.1 RP11-271A22 MAP AC128677
IGKV1/OR2-3 IGKV1/OR2-3*01 P (6) Long arm of chr2: 2q11.2 [9] W3 MAP X05102 [6]
IGKV1/OR2-6 IGKV1/OR2-6*01 P (7) Long arm of chr2: 2q11.2 [9] W6 MAP X05103 [6]
IGKV1/OR2-9 IGKV1/OR2-9*01 P (6) Long arm of chr2: 2q11.2 [9] W9 MAP X51879 [9]
IGKV1/OR2-11 IGKV1/OR2-11*01 P (6) Long arm of chr2: 2q11.2 [9] W11 MAP X51885 [9]
IGKV1/OR2-108 IGKV1/OR2-108*01 ORF Long arm of chr2: 2q12-14 [8,3] V108 MAP X51887 [3]
IGKV1/OR2-118 IGKV1/OR2-118*01 P (28) 2p11.1 (29) MAP AC018696 [16]
IGKV1/OR9-1 IGKV1/OR9-1*01 P (1) Chr9, at 9q21.11 MAP AL512605
IGKV1/OR9-2 IGKV1/OR9-2*01 P (1) 9p12 RP11-1221G12 MAP AC129778
IGKV1/OR10-1 IGKV1/OR10-1*01 P (34) Chr10, at 10q11.21 Y237C10 MAP AL031601 ABC16-2334G3 AC238517 [18]
IGKV1/OR15-118 IGKV1/OR15-118 P (9) Chr15, 15 pter-15qter [4] VkappaIcos118 MAP M20812 [11]
IGKV1/OR22-1 IGKV1/OR22-1*01 P (10) Chr22, at 22q11 [4,15] (22) VkappaI, Chr22-1 MAP Z00040 [4] IGKVP5 AC006548 [10] (23)
IGKV1/OR22-5 IGKV1/OR22-5*01 P (11) Chr22, at 22q11 [5,15] Chr22-5 MAP Z00003 [12] V14
V2b [8]
MAP Z00003 [12] IGKVP7 AC006548 [10] (24)
IGKV1/OR22-5*02 P (11) Chr22, at 22q11 [5,15] Chr22-5a MAP Z00002 [12] (22) M23849
IGKV1/ORY-1 IGKV1/ORY-1 P (31) ChrY RP11-295P22 MAP AC134879
IGKV2 IGKV2/OR2-1 IGKV2/OR2-1*01 P (8) Long arm of chr2: 2q11.2 [9] W1 MAP X05101 [6] W1a X76074 [8]
IGKV2/OR2-2 IGKV2/OR2-2*01 P (12) Long arm of chr2: 2q11.2 [9] W2 MAP X51884 [9] DPK32 X93648 [2]
IGKV2/OR2-4 IGKV2/OR2-4*01 P (13) Long arm of chr2: 2q11.2 [9] W4 MAP X51883 [9]
IGKV2/OR2-7 IGKV2/OR2-7*01 P (14) Long arm of chr2: 2q11.2 [9] W7 MAP X51881 [9]
IGKV2/OR2-7D IGKV2/OR2-7D*01 P (33) 2q11.2 (30) MAP AC092683 [17]
IGKV2/OR2-8 IGKV2/OR2-8*01 P (15) Long arm of chr2: 2q11.2 [9] W8 MAP X51880 [9] DPK33 X93649 [2] (32)
IGKV2/OR2-10 IGKV2/OR2-10*01 P (16) Long arm of chr2: 2q11.2 [9] W10 MAP X51886 [9] DPK33 (32)
IGKV2/OR22-3 IGKV2/OR22-3*01 P (17) Chr22, at 22q11 [4,15] (22) VkappaII, Chr22-3 MAP Z00041 [4] IGKVP4 AC006548 [10] (25)
IGKV2/OR22-4 IGKV2/OR22-4*01 P (18) Chr22, at 22q11 [5,15] (22) Chr22-4 MAP M20707 [11] DPK36 X93652 [2]
IGKVP6 AC006548 [10] (26)
IGKV3 IGKV3/OR2-5 IGKV3/OR2-5*01 P (19) Long arm of chr2: 2q11.2 [9] W5 MAP X51882 [9]
IGKV3/OR2-268 IGKV3/OR2-268*01 ORF 2p12, 3' side of IGKC at 1.5Mb [8,14] V268 MAP X74459 [14]
IGKV3/OR2-268*02 ORF 2p12, 3' side of IGKC at 1.5Mb [8,14] V268a MAP X74460 [14]
IGKV3/OR22-2 IGKV3/OR22-2*01 P (20) Chr22, at 22q11 [4,15] (22) VkappaIII, Chr22-2 MAP Z00042 [4] IGKVP3 AC006548 [10] (27)

MAP: Mapped sequences.

IMGT notes:
  1. (1) No INIT-CODON: ATG replaced by ACG.
  2. (2) No INIT-CODON: ATG replaced by ACG [7].
  3. (3) No INIT-CODON: ATG replaced by AAG [7].
  4. (4) No INIT-CODON: ATG replaced by ACA [7].
  5. (5) No INIT-CODON: ATG replaced by ACA.
  6. (6) STOP-CODON at position 87.
  7. (7) STOP-CODONs at position -5 and 91, and 10 bp DELETION between codons 91/92 [6].
  8. (8) STOP-CODONs at positions 35 and 36, and INSERTION of 2 bp in codon 87, leading to a frameshift [6].
  9. (9) STOP-CODON at position 87, and no INIT-CODON: ATG replaced by ACA.
  10. (10) INSERTION of 7 bp at position 1093 leading to a frameshift [4].
  11. (11) STOP-CODON at position 71 (87 IMGT numbering), and no INIT-CODON: ATG replaced by ACG [seq].
  12. (12) 1 bp DELETION at position 740, 1 bp DELETION at position 935 leading to frameshifts, and STOP-CODON in L-PART1.
  13. (13) 1 bp DELETION in L-PART1, STOP-CODON at position 36, and 2 bp INSERTION between positions 1046/1047 leading to a frameshift.
  14. (14) STOP-CODON at position 36, INSERTION of 2 bp at position 957 leading to a frameshift.
  15. (15) STOP-CODON in L-PART1, 1 bp DELETION at positions 731 and 925 leading to frameshifts.
  16. (16) STOP-CODON in L-PART1, 1 bp DELETION at positions 744 and 938 leading to frameshifts.
  17. (17) INSERTION of 3 bp between codons 22 and 23, DELETION of 1 bp at position 315 leading to a frameshift, and STOP-CODONs.
  18. (18) STOP-CODON at position 81.
  19. (19) No INIT-CODON: ATG replaced by ACG, 2 bp DELETIONs at positions 727, 831 and 833, 1 bp DELETION at position 747, leading to frameshifts.
  20. (20) Breakoff of homology after codon 79, STOP-CODONs and DELETION [4].
  21. (21) Defective DECAMER, non canonical V-HEPTAMER and V-NONAMER [1].
  22. (22) The five IGKV/OR22-5 orphons are localized on a 30 kb DNA stretch at 1,3 Mb of the centromere sequences [10].The 5' end of the cluster is telomeric, whereas the 3' end is centromeric.
  23. (23) V-REGION is 100% identical to Z00040.
  24. (24) V-REGION is 100% identical to Z00002.
  25. (25) V-REGION is 99% identical to Z00041. 4 bp (ttgt) DELETION at the same position as the Z00041 1bp DELETION leading to a frameshift. Otherwise, identity with Z00041, with the same STOP-CODONs.
  26. (26) V-REGION is 100% identical to M20707. AC006548 has an one nucleotide insertion (g) in the V-INTRON.
  27. (27) V-REGION is 99% identical to Z00042. AC006548 has an one nucleotide deletion in the FR1-IMGT compared to Z00042.
  28. (28) no INIT-CODON: ATG replaced by ACA.
  29. (29) Gene identified on Genome assembly Built 37.1 at NCBI on AC018696 (plus/minus), 110698..111148 (M. Landrum, R. Seal, G. Folch and M.-P. lefranc, IMGT (26/10/2009)).
  30. (30) Gene identified on Genome assembly Built 37.1 at NCBI on AC092683, 103208..103976 (M. Landrum, R. Seal, G. Folch and M.-P. lefranc, IMGT (26/10/2009)).
  31. (31) No INIT-CODON due to a nucleotide substitution t>c and an amino acid change M>T'.
  32. (32) DPK33 could not be assigned to either IGKV2/OR2-8 or IGKV2/OR2-10 by the authors.
  33. (33) STOP-CODON in V-REGION.
  34. (34) No INIT-CODON: ATG replaced by GTG.
IMGT references:
  1. [1] Brensing-Küppers, J. et al., Gene, 191, 173-181 (1997). PMID:9218717
  2. [2] Cox, J.P. et al., Eur. J. Immunol., 24, 827-836 (1994). PMID:8149953
  3. [3] Huber, C. et al., Nucl. Acids Res., 18, 3475-3478 (1990). PMID:2114012
  4. [4] Lötscher, E. et al., Nature, 320, 456-458 (1986). PMID:3083265
  5. [5] Meindl, A. et al., Eur. J. Immunol., 20, 1855-1863 (1990). PMID:1976522
  6. [6] Pohlenz, H.D. et al., J. Mol. Biol., 193, 241-253 (1987). PMID:3037085
  7. [7] Röschenthaler, F. et al., Biol. Chem. Hoppe-Seyler, 373, 177-186 (1992). PMID:1596359
  8. [8] Schäble, K. F. and Zachau, H. G., Biol. Chem. Hoppe-Seyler, 374, 1001-1022 (1993). PMID:8292259
  9. [9] Zimmer, F.J. et al., Biol. Chem. Hoppe-Seyler, 371, 283-290 (1990). PMID:2111145
  10. [10] Dunham, I. et al., Nature, 402, 489-495 (1999). PMID:10591208
  11. [11] Lötscher, E. et al., Gene, 69, 215-223 (1988). PMID:2853099
  12. [12] Jaenichen, H.R. et al., Nucleic Acid. Res., 12, 5249-5263 (1984). PMID:6087279
  13. [13] Straubinger, B. et al., Gene, 69, 209-214 (1988). PMID:2853098
  14. [14] Huber, C. et al., Genomics, 22, 213-215 (1994). PMID:7959772
  15. [15] Adolph, S. et al., Nucl. Acids Res., 16, 6241 (1988). PMID:3135538
  16. [16] Ozersky P. et al., Unpublished.
  17. [17] Cotton M. et al., Unpublished.
  18. [18] Schatzkamer K. et al., Unpublished.
Created:
03/02/1997
Last updated:
22/09/2023
Authors:
Valérie Barbié, Dominique Scaviner