IMGT Repertoire (RPI)

IMGT Collier de Perles for Xenopus CTXg1 (V-LIKE-DOMAIN)

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CTXg1 cDNA (P07725)
CDR-IMGT lengths: [10.7.8]

Collier CTXg1 V-LIKE-DOMAIN

This figure has been generated with the IMGT/Collier de Perles tool initially implemented by Gérard Mennessier (LPM, Montpellier, France, 25/05/1997) and further developed by Manuel Ruiz (08/09/1999) and Quentin Kaas (15/11/2001).

Legend:

Amino acids are shown in the one-letter abbreviation.
Hydrophobic amino acids (hydropathy index with positive value) and Tryptophan (W) found at a given position in more than 50 % of analysed Ig and TcR sequences are shown in blue.
All Proline (P) are shown in yellow.
Arrows indicate the direction of the beta sheets and their different designations in 3D structure. This information has to be used carefully if not supported by experimental data.
Hachured circles or squares correspond to missing positions according to the IMGT unique numbering.
Missing positions in IMGT Colliers de Perles based on 3D structures may be due to incomplete experimental data.
The CDR-IMGT are limited by amino acids shown in squares, which belong to the neighbouring FR-IMGT.

IMGT notes:

The CTX genomic DNA sequence (U43394, U43393) has allowed to describe the gene structure. The CTX gene comprises 6 exons.
The peptide signal is encoded by L-PART1 (exon 1) and L-PART2 (5' of V-exon) as for the IG and TRV genes. The V-LIKE-DOMAIN is encoded by two exons instead of being encoded by a single V-EXON (first exon: positions 1.3 to 53 (U43394), second exon: positions 54 to 123 (U43393). The splicing between the 2 exons is of the codon_start1 type.
CTX is constituted by a V-LIKE DOMAIN (this figure) and a C-LIKE-DOMAIN (not shown). The G strand has a XGXG motif which has some similarity with the F/WGXG motif of the IG and TR J-REGION.
Differences with U43394 (genomic DNA):15 T, 17 E, 24 F, 26 A, 30 P, 31 I, 32 T, 33 K

See also:

IMGT Scientific chart:
- Collier de Perles is described using the IMGT unique numbering for V-DOMAIN and V-LIKE-DOMAIN
- Definition of the FR-IMGT and CDR-IMGT regions
IMGT Index:
- IMGT Colliers de perles
IMGT Education (FR):
- La superfamille des immunoglobulines (IgSF)
Tools: