IMGT Repertoire (RPI)

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Other FCGR entries

Homo sapiens: FCGR1A, FCGR1B, FCGR1C, FCGR2B, FCGR3B
Mus musculus: FCGR1

IMGT RPI entry from gene to protein for Homo sapiens FCGR2A

Citing IMGT RPI entry for FCGR2A

Duprat, E. et al. IMGT standardization for alleles and mutations of the V-LIKE-DOMAINs and C-LIKE-DOMAINs of the immunoglobulin superfamily, Recent Research Developments in Human Genetics, 2, 111-136 (2004)

with permission from Research Signpost

IMGT gene name and definition

IMGT gene name: Homo sapiens FCGR2A
IMGT gene definition: Fc fragment of IgG, low affinity IIa, receptor for (CD32)

Chromosomal localization

Chromosome: 1
Chromosomal localization: 1q23

Gene exon/intron organization

Legend:

Length of the exons and introns are in base pairs.
Colors are according to IMGT Color menu for regions and domains

Number of alleles: 5

IMGT reference alleles

Allele name	Gene functionality	IMGT reference sequences
Allele name	Gene functionality	Clone names	Accession numbers	Molecule type
FCGR2A*01	F		M90721 (EX1) M90722 (EX2) M90723 (EX3) M90724 (EX4) M90725 (EX5) NT_004668 (EX6) M90727 (EX7) (1)	gDNA
FCGR2A*02	F		J03619	cDNA
FCGR2A*03	F	MGC:23887	BC020823 (2)	cDNA
FCGR2A*04	F	MGC:30032	BC019931 (2)	cDNA
FCGR2A*05			[1] (3)	gDNA

IMGT reference sequences (in FASTA format) for the allele(s): FCGR2A*01 to FCGR2A*05

Nucleotide sequence in FASTA format with gaps according to the IMGT unique numbering
Amino acid sequence in FASTA format with gaps according to the IMGT unique numbering
Nucleotide sequence in FASTA format without gaps
Amino acid sequence in FASTA format without gaps

Other sequences from the literature

Allele name	Gene functionality	IMGT reference sequences
Allele name	Gene functionality	Clone names	Accession numbers	Molecule type
FCGR2A*02	F		X62572 (4)	cDNA
FCGR2A*02	F		M28697 (4)	cDNA

Corresponding protein database accession numbers

Allele name	Accession numbers		Number of amino acids	Protein isoform
Allele name	Nucleotide databases	Protein databases	Number of amino acids	Protein isoform
FCGR2A*01	M90721 (EX1) M90722 (EX2) M90723 (EX3) M90724 (EX4) M90725 (EX5) NT_004668 (EX6) M90727 (EX7) (1)	SW: P12318	315 aa	N/A
FCGR2A*02	X62572 (4)		312 aa	N/A
FCGR2A*03	BC020823 (2)		314 aa	N/A
FCGR2A*04	BC019931 (2)		314 aa	N/A
FCGR2A*05	[1] (3)		64 aa	N/A

IMGT notes:

(1) The errors in the exon delimitations in M90721-M90725 are corrected in this IMGT entry and the corresponding FASTA sequences. M90726 which does not correspond to EX6 has been replaced with sequence extracted from NT_004668.
(2) This allele has a 3 nucleotide deletion in the EX3 5' end a3.2-c2.1>del(3nt) ; A1.1>del (see IMGT numbering of additional codons (or amino acids) and corresponding nucleotides ; IMGT unique numbering for C-DOMAIN and C-LIKE-DOMAIN).
(3) PCR product from position nucleotide 42 (aa N°15) to 108 nucleotides after the end of EX4.
(4) Partial in 5' (7 nucleotides missing).

IMGT references:

[1] Blood, Vol. 91, No 2, 656-662 (1998)..

Genomic sequence

Coding region sequence

The coding region (CODING-REGION) sequence starts from INIT-CODON (or its encoded amino acid) to STOP-CODON (not included).
The nucleotide sequence is extracted from cDNA (c) sequences and/or is built by artificial exon joining from genomic DNA (g) sequences. The amino acid sequence is the translation of the nucleotide sequence.

FCGR2A*01: M91645(g) M90722(g) M90723(g) M90724(g) M90725(g) M90727(g) NT_004668(g)

Nucleotide sequence

1        atggagaccc aaatgtctca gaatgtatgt cccagaaacc tgtggctgct tcaaccattg

61       acagttttgc tgctgctggc ttctgcagac agtcaagctg cagctccccc aaaggctgtg

121      ctgaaacttg agcccccgtg gatcaacgtg ctccaggagg actctgtgac tctgacatgc

181      cagggggctc gcagccctga gagcgactcc attcagtggt tccacaatgg gaatctcatt

241      cccacccaca cgcagcccag ctacaggttc aaggccaaca acaatgacag cggggagtac

301      acgtgccaga ctggccagac cagcctcagc gaccctgtgc atctgactgt gctttccgaa

361      tggctggtgc tccagacccc tcacctggag ttccaggagg gagaaaccat catgctgagg

421      tgccacagct ggaaggacaa gcctctggtc aaggtcacat tcttccagaa tggaaaatcc

481      cagaaattct cccatttgga tcccaccttc tccatcccac aagcaaacca cagtcacagt

541      ggtgattacc actgcacagg aaacataggc tacacgctgt tctcatccaa gcctgtgacc

601      atcactgtcc aagtgcccag catgggcagc tcttcaccaa tggggatcat tgtggctgtg

661      gtcattgcga ctgctgtagc agccattgtt gctgctgtag tggccttgat ctactgcagg

721      aaaaagcgga tttcagccaa ttccactgat cctgtgaagg ctgcccaatt tgagccacct

781      ggacgtcaaa tgattgccat cagaaagaga caacttgaag aaaccaacaa tgactatgaa

841      acagctgacg gcggctacat gactctgaac cccagggcac ctactgacga tgataaaaac

901      atctacctga ctcttcctcc caacgaccat gtcaacagta ataactaa

Nucleotide sequence in FASTA format (without gaps) FCGR2A*01

Amino acid sequence

1        METQMSQNVC PRNLWLLQPL TVLLLLASAD SQAAAPPKAV LKLEPPWINV LQEDSVTLTC

61       QGARSPESDS IQWFHNGNLI PTHTQPSYRF KANNNDSGEY TCQTGQTSLS DPVHLTVLSE

121      WLVLQTPHLE FQEGETIMLR CHSWKDKPLV KVTFFQNGKS QKFSHLDPTF SIPQANHSHS

181      GDYHCTGNIG YTLFSSKPVT ITVQVPSMGS SSPMGIIVAV VIATAVAAIV AAVVALIYCR

241      KKRISANSTD PVKAAQFEPP GRQMIAIRKR QLEETNNDYE TADGGYMTLN PRAPTDDDKN

301      IYLTLPPNDH VNSNN*

Amino acid sequence in FASTA format (without gap) FCGR2A*01

Legend:

Colors are according to IMGT Color menu for regions and domains
Nucleotide and amino acid letters (in bold) in purple, green or blue are according to IMGT Color menu for splicing types.

IMGT links

IMGT Repertoire

Chromosomal localization:
Alignment of alleles:
Protein displays: C-LIKE-DOMAIN
IMGT Collier de perles: C-LIKE-DOMAIN

IMGT databases

IMGT/3Dstructure-DB: 1fcg, 1h9v

External links

Nomenclature

HGNC: 3616

Genome databases

Entrez Gene: 2212
GENATLAS: 254
GeneCards: GC01P158252
GDB: 119903
OMIM: 146790

Sequence databases

EMBL: M90721, M90722, M90723, M90724, M90725, M90727
GenBank: M920721, M920722, M920723, M920724, M920725, M920727
DDBJ: M920721, M920722, M920723, M920724, M920725, M920727
Swiss-Prot: P12318
TrEMBL:
NCBI: NT_004668

Structure database

PDB: 1FCG, 1H9V