IMGT Repertoire (RPI)

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Other FCGR entries

Homo sapiens: FCGR1A, FCGR1B, FCGR1C, FCGR2A, FCGR3B
Mus musculus: FCGR1

IMGT RPI entry from gene to protein for Homo sapiens FCGR2B

Citing IMGT RPI entry for FCGR2B

Duprat, E. et al. IMGT standardization for alleles and mutations of the V-LIKE-DOMAINs and C-LIKE-DOMAINs of the immunoglobulin superfamily, Recent Research Developments in Human Genetics, 2, 111-136 (2004)

with permission from Research Signpost

IMGT gene name and definition

IMGT gene name: Homo sapiens FCGR2B
IMGT gene definition: Fc fragment of IgG, low affinity IIb, receptor for (CD32)

Chromosomal localization

Chromosome: 1
Chromosomal localization: 1q23

Gene exon/intron organization

Legend:

Length of the exons and introns are in base pairs.
Colors are according to IMGT Color menu for regions and domains

Number of alleles: 2

IMGT reference alleles

Allele name	Gene functionality	IMGT reference sequences
Allele name	Gene functionality	Clone names	Accession numbers	Molecule type
FCGR2B*01	F		NT_004668 (EX1) (1) M90729 (EX2) M90730 (EX3) M90731 (EX4) M90732 (EX5) M90733 (EX6) M90734 (EX7) M90735 (EX8)	gDNA
FCGR2B*02

IMGT reference sequences (in FASTA format) for the allele(s): FCGR2B*01 to FCGR2B*02

Nucleotide sequence in FASTA format with gaps according to the IMGT unique numbering
Amino acid sequence in FASTA format with gaps according to the IMGT unique numbering
Nucleotide sequence in FASTA format without gaps
Amino acid sequence in FASTA format without gaps

Other sequences from the literature

Allele name	Gene functionality	IMGT reference sequences
Allele name	Gene functionality	Clone names	Accession numbers	Molecule type
FCGR2B*01	F		AF543826	gDNA
	F		BC031992	gDNA
			AF433951	gDNA (2)
			AB051387	gDNA (3)
			AB050934	gDNA (4)
			X524773	cDNA splicing B (5)
			U85564	cDNA splicing B (5,6)
			U85565	cDNA splicing B (5,6)
FCGR2B*02			M31935	cDNA (7)

Corresponding protein database accession numbers

Allele name	Accession numbers		Number of amino acids	Protein isoform
Allele name	Nucleotide databases	Protein databases	Number of amino acids	Protein isoform
FCGR2B*01	NT_004668 (EX1) (1) M90729 (EX2) M90730 (EX3) (1) M90731 (EX4) M90732 (EX5) M90733 (EX6) M90734 (EX7) M90735 (EX8)	Sw: P31994	310 aa

IMGT notes:

(1) Errors in the exon delimitations in M90730. M90728 which does not correspond to EX1 has been replaced with sequence extracted from NT_004668. Exon delimitation for EX3 in M90730 is from IMGT as there are errors in the generalist database flat files.
(2) Partial EX1 to EX3.
(3) Partial EX3.
(4) Partial EX4 and EX5.
(5) Alternative splicing B corresponds to an absence of EX6.
(6) Missing STOP-CODON.
(7) Missing 5' part of EX1 a1.1-c17.2.

Genomic sequence

Coding region sequence

The coding region (CODING-REGION) sequence starts from INIT-CODON (or its encoded amino acid) to STOP-CODON (not included).
The nucleotide sequence is extracted from cDNA (c) sequences and/or is built by artificial exon joining from genomic DNA (g) sequences. The amino acid sequence is the translation of the nucleotide sequence.

FCGR2B*01: NT_004668(g) M90729(g) M90730(g) M90731(g) M90732(g) M90733(g) M90734(g) M90735(g)

Nucleotide sequence

1        atgggaatcc tgtcattctt acctgtcctt gccactgaga gtgactgggc tgactgcaag

61       tccccccagc cttggggtca tatgcttctg tggacagctg tgctattcct ggctcctgtt

121      gctgggacac ctgcagctcc cccaaaggct gtgctgaaac tcgagcccca gtggatcaac

181      gtgctccagg aggactctgt gactctgaca tgccggggga ctcacagccc tgagagcgac

241      tccattcagt ggttccacaa tgggaatctc attcccaccc acacgcagcc cagctacagg

301      ttcaaggcca acaacaatga cagcggggag tacacgtgcc agactggcca gaccagcctc

361      agcgaccctg tgcatctgac tgtgctttct gagtggctgg tgctccagac ccctcacctg

421      gagttccagg agggagaaac catcgtgctg aggtgccaca gctggaagga caagcctctg

481      gtcaaggtca cattcttcca gaatggaaaa tccaagaaat tttcccgttc ggatcccaac

541      ttctccatcc cacaagcaaa ccacagtcac agtggtgatt accactgcac aggaaacata

601      ggctacacgc tgtactcatc caagcctgtg accatcactg tccaagctcc cagctcttca

661      ccgatgggga tcattgtggc tgtggtcact gggattgctg tagcggccat tgttgctgct

721      gtagtggcct tgatctactg caggaaaaag cggatttcag ctctcccagg ataccctgag

781      tgcagggaaa tgggagagac cctccctgag aaaccagcca atcccactaa tcctgatgag

841      gctgacaaag ttggggctga gaacacaatc acctattcac ttctcatgca cccggatgct

901      ctggaagagc ctgatgacca gaaccgtatt tag

Nucleotide sequence in FASTA format (without gaps) FCGR2B*01

Amino acid sequence

1        MGILSFLPVL ATESDWADCK SPQPWGHMLL WTAVLFLAPV AGTPAAPPKA VLKLEPQWIN

61       VLQEDSVTLT CRGTHSPESD SIQWFHNGNL IPTHTQPSYR FKANNNDSGE YTCQTGQTSL

121      SDPVHLTVLS EWLVLQTPHL EFQEGETIVL RCHSWKDKPL VKVTFFQNGK SKKFSRSDPN

181      FSIPQANHSH SGDYHCTGNI GYTLYSSKPV TITVQAPSSS PMGIIVAVVT GIAVAAIVAA

241      VVALIYCRKK RISALPGYPE CREMGETLPE KPANPTNPDE ADKVGAENTI TYSLLMHPDA

301      LEEPDDQNRI *

Amino acid sequence in FASTA format (without gap) FCGR2B*01

Legend:

Colors are according to IMGT Color menu for regions and domains
Nucleotide and amino acid letters (in bold) in purple, green or blue are according to IMGT Color menu for splicing types.

IMGT links

IMGT Repertoire

Chromosomal localization:
Alignment of alleles:
Protein displays: C-LIKE-DOMAIN
IMGT Collier de perles: C-LIKE-DOMAIN

IMGT databases

IMGT/3Dstructure-DB: 2fcb

External links

Nomenclature

HGNC: 3618

Genome databases

Entrez Gene: 2213
GENATLAS: 134
GeneCards: GC01P158328
GDB:
OMIM: 604590

Sequence databases

EMBL: M90729, M90730, M90731, M90732, M90733, M90734, M90735
GenBank: M90729, M90730, M90731, M90732, M90733, M90734, M90735
DDBJ: M90729, M90730, M90731, M90732, M90733, M90734, M90735
Swiss-Prot: P31994
TrEMBL:
NCBI: NT_004668

Structure database

PDB: 2FCB