IMGT Scientific chart

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• Correspondence between the IMGT unique Lefranc numbering and the different Kabat numberings (vertical display of examples) 1997
• Correspondence between the IMGT unique Lefranc numbering and the different numberings (horizontal display) 1998
• Correspondence between numberings for CDR of different lengths (horizontal display) 2001
• IMGT unique numbering (Lefranc) and structural correspondence for the different CDR-IMGT lengths with the diverse Kabat/Chothia numberings and CDR/loop delimitations (horizontal display per locus) 2008
  • IGHV and VH
  • IGLV and V-LAMBDA

IMGT unique numbering (Lefranc) and structural correspondence for the different CDR-IMGT lengths with the diverse Kabat/Chothia numberings and CDR/loop delimitations (horizontal display per locus): IGKV and V-KAPPA

• CDR1-IMGT
• CDR2-IMGT
• CDR3-IMGT

Correspondence is shown for CDR1-IMGT and CDR2-IMGT lengths found in human and mouse germline V genes.
Correspondence for CDR3-IMGT is shown for examples quoted in Lefranc et al. 2003 [1].

CDR1-IMGT

	CDR1-IMGT length		anchor position			CDR1-IMGT												anchor position
		C																		W
IMGT	12	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41
[2]		23	24	25	26	27	27A	27B	27C	27D	27E	27F	28	29	30	31	32	33	34	35
[3,4]		23	24	25	26	27	28	29	30	31	31a	31b	31c	31d	31e	31f	32	33	34	35
[5]		23	24	25	26	27	28	29	30	30a	30b	30c	30d	30e	30f	31	32	33	34	35
IMGT	11	23	24	25	26	27	28	29	30	31	32	-	34	35	36	37	38	39	40	41
[2]		23	24	25	26	27	27A	27B	27C	27D	27E	-	28	29	30	31	32	33	34	35
[3,4]		23	24	25	26	27	28	29	30	31	31a	-	31c	31d	31e	31f	32	33	34	35
[5]		23	24	25	26	27	28	29	30	30a	30b	-	30c	30e	30f	31	32	33	34	35
IMGT	10	23	24	25	26	27	28	29	30	31	-	-	34	35	36	37	38	39	40	41
[2]		23	24	25	26	27	27A	27B	27C	27D	-	-	28	29	30	31	32	33	34	35
[5]		23	24	25	26	27	28	29	30	30a	-	-	30b	30c	30d	31	32	33	34	35
IMGT	9	23	24	25	26	27	28	29	30	31	-	-	-	35	36	37	38	39	40	41
[2] (1)		23	24	25	26	27	27A	27B	27C	28	-	-	-	29	30	31	32	33	34	35
IMGT	8	23	24	25	26	27	28	29	30	-	-	-	-	35	36	37	38	39	40	41
[2] (1)		23	24	25	26	27	27A	27B	28	-	-	-	-	29	30	31	32	33	34	35
IMGT	7	23	24	25	26	27	28	29	30	-	-	-	-	-	36	37	38	39	40	41
[2]		23	24	25	26	27	27A	28	29	-	-	-	-	-	30	31	32	33	34	35
[5]		23	24	25	26	27	28	29	30	-	-	-	-	-	30a	31	32	33	34	35
IMGT	6	23	24	25	26	27	28	29	-	-	-	-	-	-	36	37	38	39	40	41
[2]		23	24	25	26	27	28	29	-	-	-	-	-	-	30	31	32	33	34	35
[3-5]		23	24	25	26	27	28	29	-	-	-	-	-	-	30	31	32	33	34	35
IMGT	5	23	24	25	26	27	28	29	-	-	-	-	-	-	-	37	38	39	40	41
[2]		23	24	25	26	27	29	30	-	-	-	-	-	-	-	31	32	33	34	35
[3-5]		23	24	25	26	27	28	29	-	-	-	-	-	-	-	30	32	33	34	35

CDR2-IMGT

	CDR2-IMGT length	anchor position		CDR2-IMGT										anchor position
IMGT	3		55	56	57	-	-	-	-	-	-	-	65	66	67	68	69	70	71	72	-	74
[2]			49	50	51	-	-	-	-	-	-	-	52	53	54	55	56	57	58	59	-	60
[3-5]			49	50	51	-	-	-	-	-	-	-	52	53	54	55	56	57	58	59	-	60

CDR3-IMGT

	CDR3-IMGT length	anchor position		CDR3-IMGT														anchor position
			C																F
IMGT	15		104	105	106	107	108	109	110	111	111.1	112.1	112	113	114	115	116	117	118
[2]			88	89	90	91	92	93	94	95	95A	95B	95C	95D	95E	95F	96	97	98
IMGT	14		104	105	106	107	108	109	110	111	-	112.1	112	113	114	115	116	117	118
[2] (1)			88	89	90	91	92	93	94	95	-	95A	95B	95C	95D	95E	96	97	98
IMGT	13		104	105	106	107	108	109	110	111	-	-	112	113	114	115	116	117	118
[2] (1)			88	89	90	91	92	93	94	95	-	-	95A	95B	95C	95D	96	97	98
IMGT	12		104	105	106	107	108	109	110	-	-	-	112	113	114	115	116	117	118
[2] (1)			88	89	90	91	92	93	94	-	-	-	95	95A	95B	95C	96	97	98
IMGT	11		104	105	106	107	108	109	110	-	-	-	-	113	114	115	116	117	118
[2] (1)			88	89	90	91	92	93	94	-	-	-	-	95	95A	95B	96	97	98
IMGT	10		104	105	106	107	108	109	-	-	-	-	-	113	114	115	116	117	118
[2] (1)			88	89	90	91	92	93	-	-	-	-	-	94	95	95A	96	97	98
IMGT	9		104	105	106	107	108	109	-	-	-	-	-	-	114	115	116	117	118
[2]			88	89	90	91	92	93	-	-	-	-	-	-	94	95	96	97	98
[3,5]			88	89	90	91	92	93	-	-	-	-	-	-	94	95	96	97	98
IMGT	8		104	105	106	107	108	-	-	-	-	-	-	-	114	115	116	117	118
[2] (1)			88	89	90	91	92	-	-	-	-	-	-	-	94	95	96	97	98
IMGT	7		104	105	106	107	108	-	-	-	-	-	-	-	-	115	116	117	118
[2] (1)			88	89	90	91	92	-	-	-	-	-	-	-	-	95	96	97	98

Light-grey background correspond to previous CDR delimitation in [2-5].
Colors are according to IMGT color menu for CDR-IMGT and IMGT color menu for sequence alignments.

IMGT note:
(1) Added for completeness although there is no example in [2].

IMGT references:

[1]	Lefranc, M.-P. et al. "IMGT unique numbering for immunoglobulin and T cell receptor variable domains and Ig superfamily V-like domains" Dev. Comp. Immunol., 27, 55-77 (2003). PMID: 12477501 with permission from Elsevier
[2]	Kabat, E.A. et al., In: Sequences of Proteins of Immunological Interest, NIH Publication, 91-3242 (1991).
[3]	Chothia, C. and Lesk, A.M., J. Mol. Biol., 196, 901-917 (1987).
[4]	Chothia, C. et al., Nature, 342, 877-883 (1989).
[5]	Al-Lazikani, B. et al., J. Mol. Biol., 273, 927-948 (1997).

Created: 08/08/2008
Last updated: Wednesday, 12-Jun-2024 16:02:10 CEST
Editor: Chantal Ginestoux

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