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Correspondence between V numberings

Correspondence between the IMGT unique Lefranc numbering and the different Kabat numberings (vertical display of examples): Part 1 - Immunoglobulin

Princeps table: Lefranc, M.-P., The Immunologist, 7, 132-136 (1999). pdf

Compared to the princeps papers [1-3], gaps in CDR1-IMGT and CDR2-IMGT are placed at the top of the loops [4]. IMGT numbering for rearranged CDR3-IMGT is described in IMGT unique numbering for V-DOMAIN and V-LIKE-DOMAIN [4].

FR-IMGT
and
CDR-IMGT		 IMGT
strands
and
loops		 IGHV IGKV IGLV
Human IGHV6-1 Human IGKV1-5 Human IGLV2-23
IMGT
numbering [3,4]		 Kabat
numbering [5]		 Nucleotides and amino acid translation IMGT
numbering [3,4]		 Kabat
numbering [5]		 Nucleotides and amino acid translation IMGT
numbering [3,4]		 Kabat
numbering [5]		 Nucleotides and amino acid translation
FR1-IMGT A 1 1 cag GLN Q 1 1 gac ASP D 1 1 cag GLN Q
2 2 gta VAL V 2 2 atc ILE I 2 2 tct SER S
3 3 cag GLN Q 3 3 cag GLN Q 3 3 gcc ALA A
4 4 ctg LEU L 4 4 atg MET M 4 4 ctg LEU L
5 5 cag GLN Q 5 5 acc THR T 5 5 act THR T
6 6 cag GLN Q 6 6 cag GLN Q 6 6 cag GLN Q
7 7 tca SER S 7 7 tct SER S 7 7 cct PRO P
8 8 ggt GLY G 8 8 cct PRO P 8 8 gcc ALA A
9 9 cca PRO P 9 9 tcc SER S 9 9 tcc SER S
10 --- --- - 10 10 acc THR T 10 10 --- --- -
11 10 gga GLY G 11 11 ctg LEU L 11 11 gtg VAL V
12 11 ctg LEU L 12 12 tct SER S 12 12 tct SER S
13 12 gtg VAL V 13 13 gca ALA A 13 13 ggg GLY G
14 13 aag LYS K 14 14 tct SER S 14 14 tct SER S
15 14 ccc PRO P 15 15 gta VAL V 15 15 cct PRO P
B 16 15 tcg SER S 16 16 gga GLY G 16 16 gga GLY G
17 16 cag GLN Q 17 17 gac ASP D 17 17 cag GLN Q
18 17 acc THR T 18 18 aga ARG R 18 18 tcg SER S
19 18 ctc LEU L 19 19 gtc VAL V 19 19 atc ILE I
20 19 tca SER S 20 20 acc THR T 20 20 acc THR T
21 20 ctc LEU L 21 21 atc ILE I 21 21 atc ILE I
22 21 acc THR T 22 22 act THR T 22 22 tcc SER S
23 22 tgt CYS C 23 23 tgc CYS C 23 23 tgc CYS C
24 23 gcc ALA A 24 24 cgg ARG R 24 24 act THR T
25 24 atc ILE I 25 25 gcc ALA A 25 25 gga GLY G
26 25 tcc SER S 26 26 agt SER S 26 26 acc THR T
CDR1-IMGT BC 27 26 ggg GLY G 27 27 cag GLN Q 27 27 agc SER S
28 27 gac ASP D 28 *28 agt SER S 28 *27A agt SER S
29 28 agt SER S 29 *29 att ILE I 29 *27B gat ASP D
30 29 gtc VAL V 30 * --- --- - 30 *27C gtt VAL V
31 *30 tct SER S 31 * --- --- - 31 *28 ggg GLY G
32 * --- --- - 32 * --- --- - 32 * --- --- -
33 * --- --- - 33 * --- --- - 33 * --- --- -
34 *31 agc SER S 34 * --- --- - 34 * --- --- -
35 *32 aac ASN N 35 * --- --- - 35 *29 agt SER S
36 *33 agt SER S 36 *30 agt SER S 36 *30 tat TYR Y
37 *34 gct ALA A 37 *31 agc SER S 37 *31 aac ASN N
38 *35 gct ALA A 38 *32 tgg TRP W 38 *32 ctt LEU L
FR2-IMGT C 39 *35A tgg TRP W 39 33 ttg LEU L 39 33 gtc VAL V
40 *35B aac ASN N 40 34 gcc ALA A 40 34 tcc SER S
41 36 tgg TRP W 41 35 tgg TRP W 41 35 tgg TRP W
42 37 atc ILE I 42 36 tat TYR Y 42 36 tac TYR Y
43 38 agg ARG R 43 37 cag GLN Q 43 37 caa GLN Q
44 39 cag GLN Q 44 38 cag GLN Q 44 38 cag GLN Q
45 40 tcc SER S 45 39 aaa LYS K 45 39 cac HIS H
46 41 cca PRO P 46 40 cca PRO P 46 40 cca PRO P
C' 47 42 tcg SER S 47 41 ggg GLY G 47 41 ggc GLY G
48 43 aga ARG R 48 42 aaa LYS K 48 42 aaa LYS K
49 44 ggc GLY G 49 43 gcc ALA A 49 43 gcc ALA A
50 45 ctt LEU L 50 44 cct PRO P 50 44 ccc PRO P
51 46 gag GLU E 51 45 aag LYS K 51 45 aaa LYS K
52 47 tgg TRP W 52 46 ctc LEU L 52 46 ctc LEU L
53 48 ctg LEU L 53 47 ctg LEU L 53 47 atg MET M
54 49 gga GLY G 54 48 atc ILE I 54 48 att ILE I
55 50 agg ARG R 55 49 tat TYR Y 55 49 tat TYR Y
CDR2-IMGT C'C" 56 51 aca THR T 56 50 gat ASP D 56 50 gag GLU E
57 52 tac TYR Y 57 51 gcc ALA A 57 51 ggc GLY G
58 *52A tac TYR Y 58 * --- --- - 58 * --- --- -
59 *52B agg ARG R 59 * --- --- - 59 * --- --- -
60 *53 tcc SER S 60 * --- --- - 60 * --- --- -
61 * --- --- - 61 * --- --- - 61 * --- --- -
62 *54 aag LYS K 62 * --- --- - 62 * --- --- -
63 *55 tgg TRP W 63 * --- --- - 63 * --- --- -
64 *56 tat TYR Y 64 * --- --- - 64 * --- --- -
65 *57 aat ASN N 65 *52 tcc SER S 65 *52 agt SER S
FR3-IMGT C" 66 58 gat ASP D 66 53 agt SER S 66 53 aag LYS K
67 59 tat TYR Y 67 54 ttg LEU L 67 54 cgg ARG R
68 60 gca ALA A 68 55 gaa GLU E 68 55 ccc PRO P
69 61 gta VAL V 69 56 agt SER S 69 56 tca SER S
70 62 tct SER S 70 57 ggg GLY G 70 57 ggg GLY G
71 63 gtg VAL V 71 58 gtc VAL V 71 58 gtt VAL V
72 64 aaa LYS K 72 59 cca PRO P 72 59 tct SER S
73 --- --- - 73 --- --- - 73 --- --- -
74 65 agt SER S 74 60 tca SER S 74 60 aat ASN N
D 75 66 cga ARG R 75 61 agg ARG R 75 61 cgc ARG R
76 67 ata ILE I 76 62 ttc PHE F 76 62 ttc PHE F
77 68 acc THR T 77 63 agc SER S 77 63 tct SER S
78 69 atc ILE I 78 64 ggc GLY G 78 64 ggc GLY G
79 70 aac ASN N 79 65 agt SER S 79 65 tcc SER S
80 71 cca PRO P 80 66 gga GLY G 80 66 aag LYS K
81 72 gac ASP D 81 --- --- - 81 --- --- -
82 73 aca THR T 82 --- --- - 82 --- --- -
83 74 tcc SER S 83 67 tct SER S 83 67 tct SER S
84 75 aag LYS K 84 68 ggg GLY G 84 68 ggc GLY G
E 85 76 aac ASN N 85 69 aca THR T 85 69 aac ASN N
86 77 cag GLN Q 86 70 gaa GLU E 86 70 acg THR T
87 78 ttc PHE F 87 71 ttc PHE F 87 71 gcc ALA A
88 79 tcc SER S 88 72 act THR T 88 72 tcc SER S
89 80 ctg LEU L 89 73 ctc LEU L 89 73 ctg LEU L
90 81 cag GLN Q 90 74 acc THR T 90 74 aca THR T
91 82 ctg LEU L 91 75 atc ILE I 91 75 atc ILE I
92 82A aac ASN N 92 76 agc SER S 92 76 tct SER S
93 82B tct SER S 93 77 agc SER S 93 77 ggg GLY G
94 82C gtg VAL V 94 78 ctg LEU L 94 78 ctc LEU L
95 83 act THR T 95 79 cag GLN Q 95 79 cag GLN Q
96 84 ccc PRO P 96 80 cct PRO P 96 80 gct ALA A
F 97 85 gag GLU E 97 81 gat ASP D 97 81 gag GLU E
98 86 gac ASP D 98 82 gat ASP D 98 82 gac ASP D
99 87 acg THR T 99 83 ttt PHE F 99 83 gag GLU E
100 88 gct ALA A 100 84 gca ALA A 100 84 gct ALA A
101 89 gtg VAL V 101 85 act THR T 101 85 gat ASP D
102 90 tat TYR Y 102 86 tat TYR Y 102 86 tat TYR Y
103 91 tac TYR Y 103 87 tac TYR Y 103 87 tac TYR Y
104 92 tgt CYS C 104 88 tgc CYS C 104 88 tgc CYS C
germline
CDR3-IMGT		 105 93 gca ALA A 105 89 caa GLN Q 105 89 tgc CYS C
106 94 aga ARG R 106 90 cag GLN Q 106 90 tca SER S
107 95 --- --- - 107 91 tat TYR Y 107 91 tat TYR Y
108 108 92 aat ASN N 108 92 gca ALA A
109 109 93 agt SER S 109 93 ggt GLY G
110 110 94 tat TYR Y 110 94 agt SER S
111 111 95 tct SER S 111 95 agc SER S
112 112 95A act THR T
113 113 95B tta LEU L
114 114 95C --- --- -
115 115 95D --- --- -

IMGT notes:

For each V-REGION group, one germline sequence is shown with, on the left hand side of each column, the IMGT unique numbering (in bold) defined by Marie-Paule Lefranc and the corresponding numbering according to Kabat et al. [5].

Gaps (unoccupied positions) are shown with dashes.
Asteriks (*) indicate positions for which it is not possible to make changes from one numbering to the other, automatically.

Colors of amino acids are according to IMGT Color menu for sequence alignments.

For IMGT Colliers de Perles of the germline sequences (V-REGION) of this table in the IMGT unique numbering, click on the following V-GENE names. Lengths of the CDR1-IMGT, CDR2-IMGT and germline CDR3-IMGT are shown between brackets, separated by dots.

The IMGT unique numbering and IMGT Colliers de Perles for IG and TR V-DOMAIN (V-J-REGION and V-D-J-REGION) of all species are available in IMGT/3Dstructure-DB and IMGT/2Dstructure-DB.

IMGT References
[1] Lefranc, "Unique database numbering system for immunogenetics analysis", Immunology Today, 18, 509 (1997). PMID: 9386342
[2] Lefranc, M.-P. "IMGT Locus on Focus: A new section of Experimental and Clinical Immunogenetics", Exp. Clin. Immunogenet., 15, 1-7 (1998). PMID: 9619395 pdf
[3] Lefranc, M.-P., "The IMGT unique numbering for immunoglobulins, T cell Receptors and Ig-like domains", The Immunologist, 7, 132-136 (1999). pdf
[4] Lefranc, M.-P. et al., Dev. Comp. Immunol., 27, 55-77 (2003). PMID: 12477501 pdf with permission from Elsevier
[5] Kabat et al., "Sequences of Proteins of Immunological Interest", NIH Publication, 91-3242 (1991).
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