Homo sapiens IGHG1 amino acids involved in the interactions with the C1q, FcγR and FCGRT

1. Structural and biological properties of human immunoglobulins

2. Human immunoglobulin (IG) chain characteristics

3. IG interchain disulfide bridges per monomer

4. Lysines and cysteines of the Homo sapiens IGHG1, IGKC and IGLC1 and positions in the C-DOMAIN

5. Amino acid positions involved in ADCC, ADCP, CDC, half-life and half-IG exchange

6. IMGT engineered variant nomenclature: IGHG variants

The IMGT unique numbering is shown, for the Homo sapiens IGHG1 CH2 and CH3 domains involved in the interactions with the C1q, FcγR and FCGRT.

The IGHG1 amino acid sequence is the translation of J00228 (IGHG1*01). Correspondence is shown with the Eu numbering. For correspondence for the complete IGHG1 sequence, see Correspondence between the IMGT unique numbering for C-DOMAIN, the IMGT exon numbering, the Eu and Kabat numberings: Human IGHG.

AA and positions highlighted in this table are those from Amino acid positions involved in ADCC, ADCP, CDC, half-life and half-IG exchange, quoted for their interaction with the FcγR (yellow) or with the FGRT (FcRn) (orange). IGHG1 AA and positons important for the C1q binding [1, 2, 3, 4] are shown with a green background.

Strands, turns and loops for C-DOMAIN	IMGT unique numbering for C-DOMAIN	CH2		Strands, turns and loops for C-DOMAIN	IMGT unique numbering for C-DOMAIN	CH3
		IGHG1	Eu numbering			IGHG1	Eu numbering
	1.6	(A)	231		-	-	-
	1.5	P	232		-	-	-
	1.4	E	233		1.4	(G)	-
	1.3	L	234		1.3	Q	-
	1.2	L	235		1.2	P	343
	1.1	G	236		1.1	R	344
A-STRAND	1	G	237	A-STRAND	1	E	345
	2	P	238		2	P	346
	3	S	239		3	Q	347
	4	V	240		4	V	348
	5	F	241		5	Y	349
	6	L	242		6	T	350
	7	F	243		7	L	351
	8	P	244		8	P	352
	9	P	245		9	P	353
	10	K	246		10	S	354
	11	P	247		11	R	355
	12	K	248		12	D	356
	13	D	249		13	E	357
	14	T	250		14	L	358
	15	L	251		15	T	359
AB-TURN	15.1	M	252	AB-TURN	15.1	-	-
	15.2	I	253		15.2	-	-
	15.3	-	-		15.3	-	-
B-STRAND	16	S	254	B-STRAND	16	K	360
	17	R	255		17	N	361
	18	T	256		18	Q	362
	19	P	257		19	V	363
	20	E	258		20	S	364
	21	V	259		21	L	365
	22	T	260		22	T	366
	23	C	261		23	C	367
	24	V	262		24	L	368
	25	V	263		25	V	369
	26	V	264		26	K	370
BC-LOOP	27	D	265	BC-LOOP	27	G	371
	28	V	266		28	F	372
	29	S	267		29	Y	373
	30	H	268		30	P	374
	31	E	269		31	-	-
	34	D	270		34	-	-
	35	P	271		35	S	375
	36	E	272		36	D	376
	37	V	273		37	I	377
	38	K	274		38	A	378
C-STRAND	39	F	275	C-STRAND	39	V	379
	40	N	276		40	E	380
	41	W	277		41	W	381
	42	Y	278		42	E	382
	43	V	279		43	S	383
	44	D	280		44	N	384
	45	G	281		45	G	385
CD-STRAND	45.1	V	282	CD-STRAND	45.1	Q	386
	45.2	E	283		45.2	P	387
	45.3	V	284		45.3	E	388
	45.4	H	285		45.4	N	389
D-STRAND	77	N	286	D-STRAND	77	N	390
	78	A	287		78	Y	391
	79	K	288		79	K	392
	80	T	289		80	T	393
	81	K	290		81	T	394
	82	P	291		82	P	395
	83	R	292		83	P	396
	84	E	293		84	V	397
DE-TURN	84.1	E	294	DE-TURN	84.1	V	398
	84.2	Q	295		84.2	L	399
	84.3	Y	296		84.3	D	400
	84.4	N	297		84.4	S	401
	85.4	S	298		85.4	D	402
	85.3	T	299		85.3	G	403
	85.2	Y	300		85.2	S	404
	85.1	R	301		85.1	F	405
E-STRAND	85	V	302	E-STRAND	85	L	406
	86	V	303		86	Y	407
	87	S	304		87	S	408
	88	V	305		88	K	409
	89	L	306		89	L	410
	90	T	307		90	T	411
	91	V	308		91	V	412
	92	L	309		92	D	413
	93	H	310		93	K	414
	94	Q	311		94	S	415
	95	D	312		95	R	416
	96	W	313		96	W	417
F-STRAND	97	L	314	F-STRAND	97	Q	418
	98	N	315		98	Q	419
	99	G	316		99	G	420
	100	K	317		100	N	421
	101	E	318		101	V	422
	102	Y	319		102	F	423
	103	K	320		103	S	424
	104	C	321		104	C	425
FG-LOOP	105	K	322	FG-LOOP	105	S	426
	106	V	323		106	V	427
	107	S	324		107	M	428
	108	N	325		108	H	429
	109	K	326		109	E	430
	110	A	327		110	A	431
	111	-	-		111	-	-
	112	-	-		112	L	432
	113	L	328		113	H	433
	114	P	329		114	N	434
	115	A	330		115	H	435
	116	P	331		116	Y	436
	117	I	332		117	T	437
G-STRAND	118	E	333	G-STRAND	118	Q	438
	119	K	334		119	K	439
	120	T	335		120	S	440
	121	I	336		121	L	441
	122	S	337		122	S	442
	123	K	338		123	L	443
	124	A	339		124	S	444
	125	K	340		125	P	445
	-	-	-		CHS 1	G	446
	-	-	-		CHS 2	K	447