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The 'ORIENTATION' axiom is one of the seven axioms of the Formal IMGT-ONTOLOGY or IMGT-Kaleidoscope [1-3].

The 'ORIENTATION' axiom postulates that molecules, cells, organs, organisms or populations and their processes and relations have to be orientated. The 'ORIENTATION' axiom has generated concepts of orientation, for example:

[1] Giudicelli, V. and Lefranc, M.-P., Bioinformatics, 15, 1047-1054 (1999). PMID: 10745995, LIGM:221 pdf
[2] Giudicelli, V. and Lefranc, M.-P. "Le paradigme IMGT-ONTOLOGY" In: Biologie Systémique Standards et modèles (Roux M. Ed.), Collection Ecrin, Omniscience, Presses Universitaires de France, Paris, 2007, Chapitre 6, pp143-164. ISBN: 978-2-916097-12-1
[3] Duroux, P. et al., "IMGT-Kaleidoscope, the Formal IMGT-ONTOLOGY paradigm", Biochimie, 90, 570-583 (2008). Epub 2007 Sep11. PMID: 17949886