RPI-MH1Like
The RPI-MH1Like genes and proteins are members of the major histocompatibility superfamily (MhSF) other than MH, or 'MhSF other than MH' (there is no "RPI-MH2Like" identified so far) [1]. The description of their two groove (G) domains is based on the IMGT unique numbering for G domains [2]. In the IMGT definitive system [3,4], the G domain includes the G-DOMAIN of the major histocompatibility (MH) of class I (MH1) and class II (MH2) and the G-LIKE-DOMAIN of the RPI-MH1Like [1-4]. The RPI-MH1Like comprise in humans [1,5,6]:
- AZGP1 (that regulates fat degradation in adipocytes),
- CD1A to CD1E proteins (that display phospholipid antigens to T cells and participate in immune defense against microbian pathogens),
- FCGRT (that transports maternal immunoglobulins through placenta and governs neonatal immunity),
- HFE (that interacts with transferring receptor and takes part in iron homeostasis by regulating iron transport through cellular membranes),
- MICA and MICB (that are induced by stress and involved in tumor cell detection),
- MR1 (that regulates mucosal immunity),
- PROCR, previously EPCR (that interacts with activated C protein and is involved in the blood coagulation pathway),
- RAET1E, RAET1G, and RAET1L (that are inducible by retinoic acid and stimulate cytokine/chemokine production and cytotoxic activity of NK cells),
- and ULBP1, ULBP2, and ULBP3 (that are ligands for NKG2D receptor).
| [1] | Lefranc M-P. Immunoglobulin (IG) and T cell receptor genes (TR): IMGT® and the birth and rise of immunoinformatics. Front Immunol. 2014 Feb 05;5:22. doi: 10.3389/fimmu.2014.00022. Open access, PMID: 24600447 |
| [2] | Lefranc M-P, Duprat E, Kaas Q, Tranne M, Thiriot A, Lefranc G. IMGT unique numbering for MHC groove G-DOMAIN and MHC superfamily (MhcSF) G-LIKE-DOMAIN. Dev Comp Immunol (2005) 29:917-38. doi:10.1016/j.dci.2005.03.003. PMID: 15936075 |
| [3] | Lefranc M-P. IMGT unique numbering for the variable (V), constant (C), and groove (G) domains of IG, TR, MH, IgSF, and MhSF. Cold Spring Harb Protoc (2011) 6:633-42. doi:10.1101/pdb.ip85. PMID: 21632789 |
| [4] | Lefranc M-P. Immunoinformatics of the V, C, and G Domains: IMGT® Definitive System for IG, TR and IgSF, MH, and MhSF. Methods Mol Biol. 2014;1184:59-107. doi: 10.1007/978-1-4939-1115-8_4. PMID: 25048119 |
| [5] | Frigoul A, Lefranc M-P. MICA: standardized IMGT allele nomenclature, polymorphisms and diseases. In: Pandalai SG, editor. Recent Research Developments in Human Genetics, Vol. 3. Trivandrum: Research Signpost (2005). p. 95-145. |
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