IMGT Repertoire (IG and TR)

3D representation: Human (Homo sapiens) TRBC2 C-DOMAIN

Here you are: IMGT Web resources > IMGT Repertoire (IG and TR) > 3. 2D and 3D structures

TR αβ B7 (PDB: 1bd2_E)

IMGT/3Dstructure-DB card: 1bd2

The TRBC2 C-DOMAIN is shown in two different orientations.

Side view (backbone model)

	TRBC2 C-DOMAIN C-BETA
	TRBC2 C-DOMAIN C-BETA

A C-DOMAIN corresponds to the complete C-REGION, to most of the C-REGION, or to part of the C-REGION, depending on the immunoglobulin or T cell receptor chain type.
This figure shows the C-DOMAIN of a beta chain (PDB: 1bd2_E) of an alpha-beta T cell receptor. Only the C-BETA2, part of the TRB C-REGION, is displayed. The carbohydrates are not shown.

In the PDB file, the sequence includes 17 amino acids of the CONNECTING-REGION of the beta chain, however, the 3D structure only includes C-BETA2 amino acids up to position 247 (according to the IMGT unique numbering for C-DOMAIN and C-LIKE-DOMAIN).
The strands C, F and G are on the external face of C-BETA2. Strands A, B , D and E are on the interface with the C-ALPHA in the alpha-beta T cell receptor.

Legend:

C-DOMAIN loops are colored according to the IMGT color menu: TRB BC loop (red), FG loop (purple)
C-DOMAIN strands are colored according to the IMGT color menu for strand representation: A, B and C strands (orange), transversal CD strand (grey), D strand (yellow), E, F, G strands (blue).

This image has been generated with the program RASMOL version 2.6 [1] from the PDB file 1bd2 [2], containing the atomic coordinates of the complexe of a human T cell receptor B7.

See also:

References:
[1] Sayle, R. and Milner-White, E.J. TIBS, 20, 374 (1995).
[2] Ding, Y.H. et al., Immunity, 8, 403-411 (1998).