IMGT Repertoire (IG and TR)

3D representation: Human (Homo sapiens) V-DOMAINs and C-DOMAINs

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TR αβ B7 (PDB: 1bd2)

IMGT/3Dstructure-DB card: 1bd2

Side view (backbone model)

TRA V-DOMAIN V-ALPHA TRA V-J-REGION		TRB V-DOMAIN V-BETA TRB V-D-J-REGION
TRAC C-DOMAIN C-ALPHA		TRBC2 C-DOMAIN C-BETA

This figure shows the two associated V-DOMAINs and C-DOMAINs of an alpha-beta T cell receptor (alpha chain (PDB: 1bd2_D), delta chain (PDB: 1bd2_E).

The two V-DOMAINs, V-ALPHA and V-DELTA, correspond to the TRA V-J-REGION and TRB V-D-J-REGION, respectively.
The two C-DOMAINs, C-ALPHA and C-BETA2, are part of the TRA C-REGION and TRB C-REGION, respectively.
Only the extracellular domains are displayed. The carbohydrates are not shown.
In the PDB file, the sequences include 10 and 17 amino acids of the CONNECTING-REGION of the alpha and delta chains, respectively, however, the 3D structures only include amino acids up to positions 203 and 247, for the alpha and beta C-DOMAINs, respectively, according to the IMGT unique numbering for C-DOMAIN.

The TRAV-J rearrangement is the following: TRAV-TRAJP (Human TRAV cDNAs).
The TRBV-D-J rearrangement is the following: TRBV6-5-TRBD2-TRBJ2-7 (Human TRB cDNAs).

Legend:

V-DOMAIN CDR-IMGT regions and C-DOMAIN loops are colored according to the IMGT color menu:
- TRA : CDR1-IMGT and BC loop (blue), CDR2-IMGT (green), CDR3-IMGT and FG loop (dark green)
- TRB : CDR1-IMGT and BC loop (red), CDR2-IMGT (orange), CDR3-IMGT and FG loop (purple).
V-DOMAIN and C-DOMAIN strands are colored according to the IMGT color menu for strand representation: A, B and C strands (orange), D strand (yellow), E, F and G strands (blue).
V-DOMAIN C' and C'' strands (green)
C-DOMAIN transversal CD strand (grey)

This image has been generated with the program RASMOL version 2.6 [1] from the PDB file 1bd2 [2], containing the atomic coordinates of the complexe of a human T cell receptor B7.

See also:

References:
[1] Sayle, R. and Milner-White, E.J. TIBS, 20, 374 (1995).
[2] Ding, Y.H. et al., Immunity, 8, 403-411 (1998).