IMGT Repertoire (IG and TR)

3D representation: Human (Homo sapiens) V-DOMAINs and C-DOMAINs

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TR γδ G115 (PDB: 1hxm)

IMGT/3Dstructure-DB card: 1hxm

Side view (backbone model)

V-DOMAIN V-GAMMA TRG V-J-REGION TRGV9-JP [8.7.15]		V-DOMAIN V-DELTA TRD V-D-J-REGION TRDV2-D3-J1 [8.3.16]
C-DOMAIN C-GAMMA TRGC1		C-DOMAIN C-DELTA TRDC

This figure shows the two associated V-DOMAINs and C-DOMAINs of a gamma-delta T cell receptor (gamma chain (PDB: 1hxm_B), delta chain (PDB: 1hxm_A).

The two V-DOMAINs, V-GAMMA and V-DELTA, correspond to the TRG V-J-REGION and TRD V-D-J-REGION, respectively.
The two C-DOMAINs, C-GAMMA and C-DELTA, are part of the TRG C-REGION and TRD C-REGION, respectively.
Only the extracellular domains are displayed. The carbohydrates are not shown.
In the PDB file, the sequences include 10 and 17 amino acids of the CONNECTING-REGION of the gamma and delta chains, respectively, however, the 3D structures only include amino acids up to positions 124 and 120, for the gamma and delta C-DOMAINs, respectively, according to the IMGT unique numbering for C-DOMAIN.

The TRGV-J rearrangement is the following: TRGV9*01-TRGJP*01 (X72500) (Human TRGV cDNAs).
The TRDV-D-J rearrangement is the following: TRDV2*03-TRDD3*01-TRDJ*01 (X72501) (Human TRDV cDNAs).

Legend:

V-DOMAIN CDR-IMGT regions and C-DOMAIN loops are colored according to the IMGT color menu:
- TRG : CDR1-IMGT and BC loop (blue), CDR2-IMGT (green), CDR3-IMGT and FG loop (dark green)
- TRD : CDR1-IMGT and BC loop (red), CDR2-IMGT (orange), CDR3-IMGT and FG loop (purple).
V-DOMAIN and C-DOMAIN strands are colored according to the IMGT color menu for strand representation : A, B and C strands (orange), D strand (yellow), E, F and G strands (blue).
V-DOMAIN C' and C'' strands (green)
C-DOMAIN transversal CD strand (grey)

This image has been generated with the program RASMOL version 2.6 [1] from the PDB file 1hxm [2], containing the atomic coordinates of the crystal structure of a human Vgamma9/Vdelta2 T cell receptor.

See also:

References:
[1] Sayle, R. and Milner-White, E.J. TIBS, 20, 374 (1995).
[2] Allison, T.J. et al., Nature, 411, 820-824 (2001).