IMGT Repertoire (IG and TR)

3D representation: Human (Homo sapiens) C-DOMAINs

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TR γδ G115 (PDB: 1hxm)

IMGT/3Dstructure-DB card: 1hxm

Side view (backbone model)

C-DOMAIN C-GAMMA TRGC1
C-DOMAIN C-DELTA TRDC

A C-DOMAIN corresponds to the complete C-REGION, to most of the C-REGION, or to part of the C-REGION, depending on the immunoglobulin or T cell receptor chain type.
This figure shows the two associated C-DOMAINs of a gamma-delta T cell receptor gamma chain (PDB: 1hxm_B), delta chain (PDB: 1hxm_A). The two C-DOMAINs, C-GAMMA and C-DELTA are part of the TRG C-REGION and TRD C-REGION, respectively.
Only the C-DOMAINs are displayed. The carbohydrates are not shown.
In the PDB file, the sequences include 10 and 17 amino acids of the CONNECTING-REGION of the gamma and delta chains, respectively, however, the 3D structures only include amino acids up to positions 124 and 120, for the gamma and delta C-DOMAINs, respectively, according to the IMGT unique numbering for C-DOMAIN.

Legend:

C-DOMAIN loops are colored according to the IMGT color menu:
- TRG BC loop (blue), FG loop (dark green)
- TRD BC loop (red), FG loop (purple)
C-DOMAIN strands are colored according to the IMGT color menu for strand representation: A, B and C strands (orange), transversal CD strand (grey), D strand (yellow), E, F, G strands (blue).

This image has been generated with the program RASMOL version 2.6 [1] from the PDB file 1hxm [2], containing the atomic coordinates of the crystal structure of a human Vgamma9/Vdelta2 T cell receptor.

See also:

References:
[1] Sayle, R. and Milner-White, E.J. TIBS, 20, 374 (1995).
[2] Allison, T.J. et al., Nature, 411, 820-824 (2001).