IMGT Repertoire (IG and TR)

Polymorphisms:

CD2*01 (L19057): D 5, C 6, P 7, D 8, S 9, S 10, E 11, E 12, V 13, G 15, V 16, S 17, K 19, P 20, V 21, Q 22, L 23, R 24, P 25, S 26, N 27, I 28, Q 29, T 30, K 35, D 36, V 37, S 38, Q 40, K 42, K 43, T 44, E 45, S 48, H 49, R 50, K 51, I 52, E 53, I 54, L 55, N 56, W 57, Y 58, D 64, G 65, P 66, S 67, W 68, S 69, N 70, V 71, S 77, D 78, I 79, Y 80, G 81, F 82, D 83, F 87, A 88, L 89, S 90, I 91, K 92, S 93, A 94, K 95, L 96, H 101, L 103, L 104, E 105, I 106, T 107, N 108, G 114, K 115, V 116, C 117, N 118, N 120, F 121, Q 122, L 123, L 124

Legend:

Amino acids are shown in the one-letter abbreviation.
Hydrophobic amino acids (hydropathy index with positive value) and Tryptophan (W) found at a given position in more than 50% of analysed IG and TR sequences are shown in blue.
All Proline (P) are shown in yellow.
Missing positions in IMGT Colliers de Perles based on 3D structures may be due to incomplete experimental data.
Arrows indicate the direction of the beta sheets and their different designations in 3D structures. This information has to be used carefully if not supported by experimental data.
The CDR-IMGT are limited by amino acids shown in squares, which belong to the neighbouring FR-IMGT. The CDR3-IMGT extend from position 105 to position 117.
CDR-IMGT regions are colored as follows: CDR1-IMGT (blue), CDR2-IMGT (green), CDR3-IMGT (greenblue).
C at position 23 (1st-CYS), W at position 41 (CONSERVED-TRP), letter of the conserved hydrophobic amino acid at position 89, and C at position 104 (2nd-CYS) are in red. If an amino acid change occurs at these crucial positions, the letter will remain red.
Hatched circles or squares correspond to missing positions according to the IMGT unique numbering for V-DOMAIN (Lefranc et al. 2003 PMID: 12477501 ).

Collier de Perles: house mouse (Mus musculus) CD2