Colors are according to IMGT Color menu for sequence alignments and Color menu for CDR-IMGT

• Amino acids are shown in the one-letter abbreviation.
• Hydrophobic amino acids (hydropathy index with positive value) and Tryptophan (W) found at a given position in more than 50% of analysed IG and TR sequences are shown in blue.
• All Proline (P) are shown in yellow.
• Missing positions in IMGT Colliers de Perles based on 3D structures may be due to incomplete experimental data.
• Arrows indicate the direction of the beta sheets and their different designations in 3D structures. This information has to be used carefully if not supported by experimental data.