IMGT Repertoire (IG and TR)

Collier de Perles: human (Homo sapiens) CD2

SLAMF1*01 V-LIKE (AL121985)

Polymorphisms:

  • CD2*01 (AF105261): G 5, C 6, Q 7, G 8, S 9, A 10, D 11, H 12, V 13, V 14, S 15, I 16, S 17, G 18, V 19, P 20, Q 22, L 23, Q 24, P 25, N 26, S 27, I 28, Q 29, T 30, K 35, V 36, S 38, A 40, K 42, L 44, L 45, P 48, S 49, Q 50, N 51, G 52, F 53, H 54, H 55, I 56, L 57, K 58, E 64, N 65, G 66, S 67, L 68, P 69, S 70, N 71, N 77, D 78, R 79, F 80, S 81, F 82, I 83, L 87, S 88, L 90, A 93, A 94, Q 95, Q 96, Q 97, S 99, G 100, L 101, C 103, L 104, E 105, V 106, T 107, S 108, I 109, S 113, G 114, K 115, Q 117, T 118, A 119, T 120, Q 122, V 123, F 124, V 125, F 126

On one layer

On two layers

Colors are according to IMGT Color menu for sequence alignments and Color menu for CDR-IMGT

Legend:
  • Amino acids are shown in the one-letter abbreviation.
  • Hydrophobic amino acids (hydropathy index with positive value) and Tryptophan (W) found at a given position in more than 50% of analysed IG and TR sequences are shown in blue.
  • All Proline (P) are shown in yellow.
  • Missing positions in IMGT Colliers de Perles based on 3D structures may be due to incomplete experimental data.
  • Arrows indicate the direction of the beta sheets and their different designations in 3D structures. This information has to be used carefully if not supported by experimental data.
  • The CDR-IMGT are limited by amino acids shown in squares, which belong to the neighbouring FR-IMGT. The CDR3-IMGT extend from position 105 to position 117.
  • CDR-IMGT regions are colored as follows: CDR1-IMGT (blue), CDR2-IMGT (green), CDR3-IMGT (greenblue).
  • C at position 23 (1st-CYS), W at position 41 (CONSERVED-TRP), letter of the conserved hydrophobic amino acid at position 89, and C at position 104 (2nd-CYS) are in red. If an amino acid change occurs at these crucial positions, the letter will remain red.
  • Hatched circles or squares correspond to missing positions according to the IMGT unique numbering for V-DOMAIN (Lefranc et al. 2003 PMID: 12477501 PDF).

IMGT notes:
The proteolytic cleavage site between the leader peptide and the V-REGION is putative and the assignment of amino acid 1 to one or the other region is uncertain.

See also:
Created:
23/02/2011
Last updated:
Wednesday, 31-Jul-2024 18:17:32 CEST
Authors:
François Ehrenmann, Chantal Ginestoux and Patrice Duroux