IMGT Repertoire (IG and TR)

Collier de Perles: house mouse (Mus musculus) CD2

SLAMF1*01 V-LIKE (AF164519)

Polymorphisms:

  • CD2*01 (L19057): D 5, C 6, P 7, D 8, S 9, S 10, E 11, E 12, V 13, G 15, V 16, S 17, K 19, P 20, V 21, Q 22, L 23, R 24, P 25, S 26, N 27, I 28, Q 29, T 30, K 35, D 36, V 37, S 38, Q 40, K 42, K 43, T 44, E 45, S 48, H 49, R 50, K 51, I 52, E 53, I 54, L 55, N 56, W 57, Y 58, D 64, G 65, P 66, S 67, W 68, S 69, N 70, V 71, S 77, D 78, I 79, Y 80, G 81, F 82, D 83, F 87, A 88, L 89, S 90, I 91, K 92, S 93, A 94, K 95, L 96, H 101, L 103, L 104, E 105, I 106, T 107, N 108, G 114, K 115, V 116, C 117, N 118, N 120, F 121, Q 122, L 123, L 124

On one layer

On two layers

Colors are according to IMGT Color menu for sequence alignments and Color menu for CDR-IMGT

Legend:
  • Amino acids are shown in the one-letter abbreviation.
  • Hydrophobic amino acids (hydropathy index with positive value) and Tryptophan (W) found at a given position in more than 50% of analysed IG and TR sequences are shown in blue.
  • All Proline (P) are shown in yellow.
  • Missing positions in IMGT Colliers de Perles based on 3D structures may be due to incomplete experimental data.
  • Arrows indicate the direction of the beta sheets and their different designations in 3D structures. This information has to be used carefully if not supported by experimental data.
  • The CDR-IMGT are limited by amino acids shown in squares, which belong to the neighbouring FR-IMGT. The CDR3-IMGT extend from position 105 to position 117.
  • CDR-IMGT regions are colored as follows: CDR1-IMGT (blue), CDR2-IMGT (green), CDR3-IMGT (greenblue).
  • C at position 23 (1st-CYS), W at position 41 (CONSERVED-TRP), letter of the conserved hydrophobic amino acid at position 89, and C at position 104 (2nd-CYS) are in red. If an amino acid change occurs at these crucial positions, the letter will remain red.
  • Hatched circles or squares correspond to missing positions according to the IMGT unique numbering for V-DOMAIN (Lefranc et al. 2003 PMID: 12477501 PDF).

IMGT notes:
The proteolytic cleavage site between the leader peptide and the V-REGION is putative and the assignment of amino acid 1 to one or the other region is uncertain.

See also:
Created:
23/02/2011
Last updated:
Wednesday, 23-Oct-2024 09:53:41 CEST
Authors:
François Ehrenmann, Chantal Ginestoux and Patrice Duroux