- IGHV4-4*02 (X92232): S 16, Y 103
- IGHV4-4*03 (MH779623): Y 103
- IGHV4-4*04 (X92253): I 25, Y 103
- IGHV4-4*05 (X92254): L 7, Y 103
- IGHV4-4*06 (Z75355): X 48, X 49, M 78, T 82, Y 103
- IGHV4-4*07 (X62112): S 16, E 17, T 24, Y 37, Y 38, I 42, A 46, R 55, T 58, M 78, T 82, Y 103
- IGHV4-4*08 (KC713942): S 16, E 17, T 24, Y 37, Y 38, I 42, Y 55, T 58, T 82, Y 103
- IGHV4-4*09 (MK471384): S 16, E 17, T 24, Y 37, Y 38, I 42, Y 55, T 58, T 82, Y 103
Colors are according to IMGT Color menu for sequence alignments and Color menu for CDR-IMGT
- Amino acids are shown in the one-letter abbreviation.
- Hydrophobic amino acids (hydropathy index with positive value) and Tryptophan (W) found at a given position in more than 50% of analysed IG and TR sequences are shown in blue.
- All Proline (P) are shown in yellow.
- The CDR-IMGT are limited by amino acids shown in squares, which belong to the neighbouring FR-IMGT. The CDR3-IMGT extend from position 105 to position 117.
- Missing positions in IMGT Colliers de Perles based on 3D structures may be due to incomplete experimental data.
- Arrows indicate the direction of the beta sheets and their different designations in 3D structures. This information has to be used carefully if not supported by experimental data.
- CDR-IMGT regions are colored as follows: CDR1-IMGT (blue), CDR2-IMGT (green), CDR3-IMGT (greenblue).
- C at position 23 (1st-CYS), W at position 41 (CONSERVED-TRP), letter of the conserved hydrophobic amino acid at position 89, and C at position 104 (2nd-CYS) are in red.
If an amino acid change occurs at these crucial positions, the letter will remain red.
- Hatched circles or squares correspond to missing positions according to the IMGT unique numbering for V-DOMAIN
(Lefranc et al. 2003 PMID: 12477501
The proteolytic cleavage site between the leader peptide and the V-REGION is putative and the assignment of amino acid 1 to one or the other region is uncertain.
- Last updated:
- Tuesday, 21-Jan-2020 21:00:15 CET
- François Ehrenmann, Patrice Duroux, Chantal Ginestoux
- Scientific officer:
- Marie-Paule Lefranc