Citing IMGT dynamic tools: Sanou G., Zeitoun G. et al. IMGT® at scale: FAIR, Dynamic and Automated Tools for Immune Locus Analysis, Nucleic Acids Research. 2025;,gkaf1024. doi: 10.1093/nar/gkaf1024 (Free Article) PMID: 41091930.
Program version: v. 

Add information about removed genes/alleles.
May 15th, 2025.

Add the possibility to obtain a gene table per strain (for mouse now and for other species later) and allotypes/isotypes for human.
September 25th, 2024.

Bibliographical references in alphabetic order, small design changes and addition of "NL" for non-localized gene.
June 14th, 2024.

Addition of 'Score for IMGT allele confirmation' as well as NCBI TPA accession numbers.
September 20th, 2023.

Implementation of the dynamic gene table.

Gene table legend:

"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene, when the data have been confirmed by several studies.

Functionality is shown in parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.

IMGT allele confirmation: A scoring system is employed to indicate the number of IMGT/LIGM-DB reference sequences and other sequences from the literature in which an IG or TR gene allele has been identified and annotated.

Removed genes/alleles
If a gene/allele existence or name has to be changed, the old name or gene/allele would be deleted and its name won't be reused. They are kept in the gene table for historical reasons.
A single star ()
indicates that an IG or TR gene allele is annotated in the reference sequence only.
Two stars ()
indicate that an IG or TR gene allele is annotated in its reference sequence and in one sequence from the literature.
Three stars ()
indicate that an IG or TR gene allele is annotated in its reference sequence and in at least two sequences from the literature.
In the Excel file, the stars are represented by the plus symbol (+).

Click on:
  • IMGT gene name to get the corresponding IMGT/GENE-DB entry (link).
  • IMGT allele name to see the corresponding Alignments of alleles (link).
  • Accession number to get the corresponding IMGT/LIGM-DB entry (link).
  • MAP: mapped sequences. Click to access GENE-DB «LOCALIZATION IN GENOME ASSEMBLIES» (link).
  • [number] to access the corresponding IMGT reference (popover).
  • (number) to see the corresponding IMGT note (popover).
Options:
  • You can show/hide columns (), download data () or put the table in fullscreen () using buttons.
See also (IMGT Scientific chart):
Select a species and a IMGT group to get the gene table:
Only IMGT available species/group are shown in the drop-down list.
The gene table can take several seconds to appear, please be patient.

The 7 human (Homo sapiens) IGKV subgroups belong to three clans (Figure IGKV clans). Clans comprise, respectively:

IGKV gene names are designated by a number for the subgroup, followed by a dash and a number for the localization from 3' to 5' in the locus. The IGKV genes of the distal duplicated V-CLUSTER are designated by the same number as the corresponding genes in the proximal V-CLUSTER, with the letter D added.

Gene table of human (Homo sapiens) IGKV (orphon) IMGT group:
IMGT sub­groupIMGT gene nameIMGT allele nameScore for
IMGT allele
confirmation		FctChromosomosal
localization		R T PrIMGT/LIGM-DB reference sequencesIMGT/LIGM-DB sequences from the literature
Clone namesAccession
numbers		Positions
in the sequence
(L-V-GENE-UNIT)
or V-REGION (*)		Secondary
accession
numbers		Clone namesAccession
numbers		Positions
in the sequence
(L-V-GENE-UNIT)
or V-REGION (*)
IGKV1IGKV1/OR-2 IGKV1/OR-2*01 P (1) Z2 X64640 [15] 168-681
IGKV1IGKV1/OR-3 IGKV1/OR-3*01 P (2) Z3 X64641 [15] 426-939
IGKV1IGKV1/OR-4 IGKV1/OR-4*01 P (1) Z4 X64642 [15] 183-687
IGKV1IGKV1/OR1-1 IGKV1/OR1-1*01 P (1) 1 pter-1qter Chr1 M20809 [10] 113-617
IGKV1IGKV1/OR2-0 IGKV1/OR2-0*01 ORF 2p11.2 Z0 Y08392 [1] 320-606 *
IGKV1IGKV1/OR2-1 IGKV1/OR2-1*01 P 2p11.1 M20813 [17] 320-606 * RP11-389I13 AC127391 [11] complement(107866-108370)
IGKV1IGKV1/OR2-2 IGKV1/OR2-2*01 P (3) 2p11.1 RP11-271A22 AC128677 [16] complement(125215-125719)
IGKV1IGKV1/OR2-3 IGKV1/OR2-3*01 P (4) 2q11.2 W3 X05102 [13] 600-1104
IGKV1IGKV1/OR2-6 IGKV1/OR2-6*01 P 2q11.2 W6 X05103 [13] 320-596 *
IGKV1IGKV1/OR2-9 IGKV1/OR2-9*01 P (4) 2q11.2 W9 X51879 [19] 294-798
IGKV1IGKV1/OR2-11 IGKV1/OR2-11*01 P (5) 2q11.2 W11 X51885 [19] 169-673
IGKV1IGKV1/OR2-108 IGKV1/OR2-108*01 ORF 2q12-2q14 V108 X51887 [5] 322-608 *
IGKV1IGKV1/OR2-118 IGKV1/OR2-118*01 P (6) 2p11.1 AC018696 [12] complement(110726-111012) *
IGKV1IGKV1/OR9-1 IGKV1/OR9-1*01 P (7) 9q21.11 AL512605 complement(83563-84076)
IGKV1IGKV1/OR9-2 IGKV1/OR9-2*01 P (3) 9p12 RP11-1221G12 AC129778 [4,18] complement(148085-148598)
IGKV1IGKV1/OR10-1 IGKV1/OR10-1*01 P (6) 10q11.21 AL031601 84082-84580
IGKV1IGKV1/OR15-118 IGKV1/OR15-118*01 P (8) 15 pter-15qter VkappaIcos118 M20812 [10] 120-624
IGKV1IGKV1/OR22-1 IGKV1/OR22-1*01 P 22q11 VkappaI,Chr22-1 Z00040 [9] 853-1146 * IGKVP5 AC006548 [14] ° Unknown
IGKV1IGKV1/OR22-5 IGKV1/OR22-5*01 P (8) 22q11 Chr22-5 Z00003 [7,8] 130-634 IGKVP7 AC006548 [14] ° Unknown
IGKV1IGKV1/OR22-5 IGKV1/OR22-5*02 P (8) 22q11 Chr22-5a Z00002 [7,8] 219-723 M23849 #g [8]
IGKV1IGKV1/ORY-1 IGKV1/ORY-1*01 P (9) Y AC134879 [2,18] 118665-119169
IGKV2IGKV2/OR2-1 IGKV2/OR2-1*01 P 2q11.2 W1 X05101 [13] 824-1127 *
IGKV2IGKV2/OR2-2 IGKV2/OR2-2*01 P 2q11.2 W2 X51884 [19] 683-982 *
IGKV2IGKV2/OR2-4 IGKV2/OR2-4*01 P 2q11.2 W4 X51883 [19] 775-1078 *
IGKV2IGKV2/OR2-7 IGKV2/OR2-7*01 P (10) 2q11.2 W7 X51881 [19] 686-989 *
IGKV2IGKV2/OR2-7D IGKV2/OR2-7D*01 P (11) 2q11.2 AC092683 [3] 103208-103976
IGKV2IGKV2/OR2-8 IGKV2/OR2-8*01 P 2q11.2 W8 X51880 [19] 674-973 *
IGKV2IGKV2/OR2-10 IGKV2/OR2-10*01 P 2q11.2 W10 X51886 [19] 687-986 *
IGKV2IGKV2/OR22-3 IGKV2/OR22-3*01 P 22q11 VkappaII,Chr22-3 Z00041 [9] 196-499 * IGKVP4 AC006548 [14] ° Unknown
IGKV2IGKV2/OR22-4 IGKV2/OR22-4*01 P (4) 22q11 Chr22-4 M20707 [10] 202-973
IGKV3IGKV3/OR2-5 IGKV3/OR2-5*01 P 2q11.2 W5 X51882 [19] 733-1013 *
IGKV3IGKV3/OR2-268 IGKV3/OR2-268*01 ORF 2p12 V268 X74459 [6] 370-659 *
IGKV3IGKV3/OR2-268 IGKV3/OR2-268*02 ORF 2p12 V268a X74460 [6] 370-659 *
IGKV3IGKV3/OR22-2 IGKV3/OR22-2*01 P 22q11 VkappaIII,Chr22-2 Z00042 [9] 859-1095 * IGKVP3 AC006548 [14] ° Unknown
IMGT notes: ↑
  1. INIT-CODON is replaced by Tyr
  2. INIT-CODON is replaced by lys
  3. No INIT-CODON: ATG replaced by ACG
  4. in frame STOP-CODON in FR3-IMGT
  5. in frame STOP-CODON in FR3_IMGT
  6. No INIT-CODON
  7. No INIT-CODON : atg is replaced by acg
  8. in frame STOP-CODON in FR3-IMGT, INIT-CODON is replaced by Tyr
  9. No INIT-CODON due to a nucleotide substitution t>c and an amino acid change M>T, leading to a frameshift in L-PART1
  10. Stop codon in FR2-IMGT. Insertion in FR3-IMGT leading to a frameshift
  11. in frame STOP-CODON in V-REGION
IMGT references: ↑
  1. Brensing-Kueppers J. et al., The human immunoglobulin kappa locus on yeast artificial chromosomes, Gene, vol. 191, no. 2, 1997, pp. 173-181. DOI: 10.1016/S0378-1119(97)00056-5
  2. Cordum H. et al., The sequence of Homo sapiens BAC clone RP11-295P22, Unpublished.
  3. Cotton M. et al., The sequence of Homo sapiens BAC clone RP11-734K23, Unpublished.
  4. Du H. et al., The sequence of Homo sapiens BAC clone RP11-1221G12, Unpublished.
  5. Huber C. et al., A human immunoglobulin kappa orphon without sequence defects may be the product of a pericentric inversion, Nucleic Acids Res, vol. 18, no. 12, 1990, pp. 3475-3478. DOI: 10.1093/nar/18.12.3475
  6. Huber C. et al., A potentially functional V kappa gene at a distance of 1.5 Mb from the immunoglobulin kappa locus, Genomics, vol. 22, no. 1, 1994, pp. 213-215. DOI: 10.1006/geno.1994.1365
  7. Jaenichen H.R, 1984.
  8. Jaenichen H.R. et al., Composite human VK genes and a model of their evolution, Nucleic Acids Res, vol. 12, no. 13, 1984, pp. 5249-5263. DOI: 10.1093/nar/12.13.5249
  9. Loetscher E. et al., Dispersed human immunoglobulin kappa light chain genes, Nature, vol. 320, no. 6061, 1986, pp. 456-458. DOI: 10.1038/320456a0
  10. Loetscher E. et al., Localization, analysis and evolution of transported human immunoglobulin V(k) genes, Gene, vol. 69, no. 2, 1988, pp. 215-223. DOI: 10.1016/0378-1119(88)90432-5
  11. Meyer R. et al., The sequence of Homo sapiens BAC clone RP11-389I13, Unpublished.
  12. Ozersky P. et al., The sequence of Homo sapiens BAC clone RP11-575H3, Unpublished.
  13. Pohlenz H.D. et al., The human V kappa locus. Characterization of extended immunoglobulin gene regions by cosmid cloning, J. Mol. Biol, vol. 193, no. 2, 1987, pp. 241-253. DOI: 10.1016/0022-2836(87)90216-6
  14. Ray L.A. et al., Homo sapiens Chromosome 22q11 PAC Clone p20k14 In CES Region, Unpublished.
  15. Roschenthaler F. et al., Of orphons and UHOs. Delimitation of the germline repertoire of human immunoglobulin kappa genes, Biol. Chem. Hoppe-Seyler, vol. 373, no. 4, 1992, pp. 177-186. PUBMED: 1596359
  16. Spalding L. et al., The sequence of Homo sapiens BAC clone RP11-271A22, Unpublished.
  17. Straubinger B. et al., The Z family, a group of transposed human immunoglobulin V kappa genes, Gene, vol. 69, no. 2, 1988, pp. 209-214. DOI: 10.1016/0378-1119(88)90431-3
  18. Wilson R, Toward a complete human genome sequence, Genome Res, vol. 8, no. 11, 1998, pp. 1097-1108. PUBMED: 9847074
  19. Zimmer F.J. et al., Evolution of a group of transposed human V kappa genes, Biol. Chem. Hoppe-Seyler, vol. 371, no. 3, 1990, pp. 283-290. PUBMED: 2111145