Citing IMGT databases: Manso T. et al. IMGT® databases, related tools and web resources through three main axes of research and development. Nucleic Acids Res. 2022 Jan 7;50(D1):D1262-D1272. doi: 10.1093/nar/gkab1136 PMID: 34875068 Free PMC article.
Program version: v. 

Add the possibility to obtain a gene table per strain (for mouse now and for other species later) and allotypes/isotypes for human.
September 25th, 2024.

Bibliographical references in alphabetic order, small design changes and addition of "NL" for non-localized gene.
June 14th, 2024.

Addition of 'Score for IMGT allele confirmation' as well as NCBI TPA accession numbers.
September 20th, 2023.

Implementation of the dynamic gene table.

Gene table legend:

"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene, when the data have been confirmed by several studies.

Functionality is shown in parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.

IMGT allele confirmation: a scoring system is employed to signify the frequency of occurrences of a specific allele within sequence data. A single star () indicates that no instances of the allele have been identified in the literature. Two stars () indicate the discovery of one literature sequence containing the allele. If more than one literature sequence is found to contain the allele, it is designated with three stars (). In the Excel file, the stars are represented by the plus symbol (+).

Click on:
  • IMGT gene name to get the corresponding IMGT/GENE-DB entry (link).
  • IMGT allele name to see the corresponding Alignments of alleles (link).
  • Accession number to get the corresponding IMGT/LIGM-DB entry (link).
  • MAP: mapped sequences. Click to access GENE-DB «LOCALIZATION IN GENOME ASSEMBLIES» (link).
  • [number] to access the corresponding IMGT reference (popover).
  • (number) to see the corresponding IMGT note (popover).
Options:
  • You can show/hide columns (), download data () or put the table in fullscreen () using buttons.
See also (IMGT Scientific chart):
Select a species and a IMGT group to get the gene table:
Only IMGT available species/group are shown in the drop-down list.
The gene table can take several seconds to appear, please be patient.

Click here for Number of genes as deduced by RFLP analysis.

Gene table of house mouse (Mus musculus) IGLC IMGT group:
IMGT gene nameIMGT allele nameScore for
IMGT allele
confirmation		FctChromosomosal
localization		ExonsR T PrIMGT/LIGM-DB reference sequencesIMGT/LIGM-DB sequences from the literature
Clone namesStrainAccession
numbers		Positions
in the sequence		Secondary
accession
numbers		Clone namesStrainAccession
numbers		Positions
in the sequence
IGLC1 IGLC1*01 F 16A3 (13.0 cM) C-REGION
RTPr
++
 Clambda1 BALB/c J00587 [1,9] MAP 30-346 129S1_SvImJ IMGT000124 208345-208662
BALB/c X58411 [11] (2) 6449-6765
BALB_cJ IMGT000126 208357-208673
CM001009.3 C57BL/6J IMGT000117 [5,6] 208624-208940
DBA_2J IMGT000134 208289-208605
NOD/SCID IMGT000211 [7] 208611-208927
IGLC1 IGLC1*02 P (1) 16A3 (13.0 cM) C-REGION BALB/c V00814 [2] 29->165
IGLC2 IGLC2*01 F 16A3 (13.0 cM) C-REGION
RTPr
++
 Clambda2 BALB/c J00595 [3,9] MAP 27-340 J00592 [4,12,13] 29-342
129S1_SvImJ IMGT000124 71561-71875
BALB/c X58414 [9,11] (3) 1834-2147
BALB_cJ IMGT000126 71578-71891
CM001009.3 C57BL/6J IMGT000117 [5,6] 71843-72156
DBA_2J IMGT000134 71514-71827
NOD/SCID IMGT000211 [7] 71833-72146
IGLC3 IGLC3*01 F 16A3 (13.0 cM) C-REGION
RTPr
++
 Clambda3 BALB/c J00585 [9] MAP 27-340 129S1_SvImJ IMGT000124 204735-205049
BALB/c X58411 [11] (4) 2837-3150
BALB/c X58415 [10] 53-366
BALB_cJ IMGT000126 204747-205060
CM001009.3 C57BL/6J IMGT000117 [5,6] 205014-205327
DBA_2J IMGT000134 204679-204992
NOD/SCID IMGT000211 [7] 205001-205314
IGLC4 IGLC4*01 P (2) 16A3 (13.0 cM) C-REGION J558/eCL4 (5) BALB/c X58416 [8,10] 53-362 Clambda4 BALB/c J00598 [3,9] (6) 27-337
M315/eCL4 BALB/c X58410 [8,10] (7) 54-363
BALB/c X58414 [9,11] (3) 5374-5684
IGLC4 IGLC4*02 F 16A3 (13.0 cM) C-REGION C57BL/6J IMGT000117 [5,6] MAP 75383-75693 129S1_SvImJ IMGT000124 75101-75412
BALB_cJ IMGT000126 75118-75428
DBA_2J IMGT000134 75054-75364
NOD/SCID IMGT000211 [7] 75373-75683
IMGT notes: ↑
  1. Partial C-REGION pseudogene due to a STOP-CODON at position 23 (may be due to a sequencing error). ACT position 43, 44, 45, GAG position 46, 47, 48, A position 69 and A position 132 are probably sequencing errors.
  2. DELETION of 1 bp at position 119 in codon 40 leading to a frameshift.
  3. X58414 contains the IGLJ2, IGLC2, IGLJ4 and IGLC4 genes from the BALB/c MOPC 315 B cell line. Originally these genes were submitted independently (X58414 being the IGLC2 accession number). Secondary accession numbers of X58414 correspond to the primary accession numbers of IGLJ2 (X58420/M28321), IGLJ4 (X58422/M28324) and IGLC4 (X58416) from MOPC 315. The secondary accession number X58410/M28329 corresponds to the primary accession number of IGLC4 from BALB/c J 558 cell line, whose sequence is identical to that of MOPC 315.
  4. X58411 contains the IGLJ1, IGLC1, IGLJ3 and IGLC3 genes from the BALB/c MOPC 315 B cell line. Originally these genes were submitted independently (X58411 being the IGLC1 accession number). Secondary accession numbers of X58411 correspond to the primary accession numbers of IGLJ1 (X58419/M28320), IGLJ3 (X58421/M28322/M28323) and IGLC3 (X58415/M28327) from MOPC 315.
  5. From B cell line J558.
  6. Conflict with X58416 and X58410 due to INSERTION of g (173) and c (329), and DELETION of c (325), which may be sequencing errors [4].
  7. From B cell line MOPC 315.
IMGT references: ↑
  1. Arp B. et al., Sequences of immunoglobulin lambda 1 genes in a lambda 1 defective mouse strain, Nature, vol. 298, no. 5870, 1982, pp. 184-187. DOI: 10.1038/298184a0
  2. Bernard O. et al., Sequences of mouse immunoglobulin light chain genes before and after somatic changes, Cell, vol. 15, no. 4, 1978, pp. 1133-1144. DOI: 10.1016/0092-8674(78)90041-7
  3. Blomberg B. et al., DNA sequences of the joining regions of mouse lambda light chain immunoglobulin genes, Proc. Natl. Acad. Sci. U.S.A, vol. 79, no. 2, 1982, pp. 530-533. PUBMED: 6804942
  4. Bothwell A.L. et al., Somatic variants of murine immunoglobulin lambda light chains, Nature, vol. 298, no. 5872, 1982, pp. 380-382. DOI: 10.1038/298380a0
  5. Church,D.M. et al., Lineage-specific biology revealed by a finished genome assembly of the mouse, PLoS Biol (2009), PUBMED: 19468303
  6. Church,D.M. et al., Modernizing reference genome assemblies, PLoS Biol, vol. 9, no. 7, 2011, PUBMED: 21750661
  7. Schmid-Siegert E. et al., Reference mouse strain assemblies for BALB/c Nude and NOD/SCID mouse models, Unpublished.
  8. Selsing E. et al., Evolution of mouse immunoglobulin lambda genes, Proc. Natl. Acad. Sci. U.S.A, vol. 79, 1982, pp. 4681-4685. Patent ID: 83014953
  9. Selsing E. et al., Evolution of mouse immunoglobulin lambda genes, Proc. Natl. Acad. Sci. U.S.A, vol. 79, no. 15, 1982, pp. 4681-4685. PUBMED: 6812053
  10. Weiss S. et al., Somatic point mutations in unrearranged immunoglobulin gene segments encoding the variable region of lambda light chains, EMBO J, vol. 6, 1987, pp. 927-932. Patent ID: 87246527
  11. Weiss S. et al., Somatic point mutations in unrearranged immunoglobulin gene segments encoding the variable region of lambda light chains, EMBO J, vol. 6, no. 4, 1987, pp. 927-932. PUBMED: 3109891
  12. Wu G.E. et al., Nucleotide sequence of a chromosomal rearranged lambda 2 immunoglobulin gene of mouse, Nucleic Acids Res, vol. 10, no. 13, 1982, pp. 3831-3843. DOI: 10.1093/nar/10.13.3831
  13. Wu G.E. et al., Secretion of a lambda 2 immunoglobulin chain is prevented by a single amino acid substitution in its variable region, Cell, vol. 33, no. 1, 1983, pp. 77-83. DOI: 10.1016/0092-8674(83)90336-7