Citing IMGT dynamic tools: Sanou G., Zeitoun G. et al. IMGT® at scale: FAIR, Dynamic and Automated Tools for Immune Locus Analysis, Nucleic Acids Research. 2025;,gkaf1024. doi: 10.1093/nar/gkaf1024 (Free Article) PMID: 41091930.
Program version: v. 

Add information about removed genes/alleles.
May 15th, 2025.

Add the possibility to obtain a gene table per strain (for mouse now and for other species later) and allotypes/isotypes for human.
September 25th, 2024.

Bibliographical references in alphabetic order, small design changes and addition of "NL" for non-localized gene.
June 14th, 2024.

Addition of 'Score for IMGT allele confirmation' as well as NCBI TPA accession numbers.
September 20th, 2023.

Implementation of the dynamic gene table.

Gene table legend:

"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene, when the data have been confirmed by several studies.

Functionality is shown in parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.

IMGT allele confirmation: A scoring system is employed to indicate the number of IMGT/LIGM-DB reference sequences and other sequences from the literature in which an IG or TR gene allele has been identified and annotated.

Removed genes/alleles
If a gene/allele existence or name has to be changed, the old name or gene/allele would be deleted and its name won't be reused. They are kept in the gene table for historical reasons.
A single star ()
indicates that an IG or TR gene allele is annotated in the reference sequence only.
Two stars ()
indicate that an IG or TR gene allele is annotated in its reference sequence and in one sequence from the literature.
Three stars ()
indicate that an IG or TR gene allele is annotated in its reference sequence and in at least two sequences from the literature.
In the Excel file, the stars are represented by the plus symbol (+).

Click on:
  • IMGT gene name to get the corresponding IMGT/GENE-DB entry (link).
  • IMGT allele name to see the corresponding Alignments of alleles (link).
  • Accession number to get the corresponding IMGT/LIGM-DB entry (link).
  • MAP: mapped sequences. Click to access GENE-DB «LOCALIZATION IN GENOME ASSEMBLIES» (link).
  • [number] to access the corresponding IMGT reference (popover).
  • (number) to see the corresponding IMGT note (popover).
Options:
  • You can show/hide columns (), download data () or put the table in fullscreen () using buttons.
See also (IMGT Scientific chart):
Select a species and a IMGT group to get the gene table:
Only IMGT available species/group are shown in the drop-down list.
The gene table can take several seconds to appear, please be patient.

Note that AE000661 encompasses M94081 from TRAJ61 to TRAJ46, and AE000662 encompasses M94081 from TRAJ45 to TRAJ1. Sequencing and/or typing errors initially detected by IMGT in M94081 sequence (TRAJ15, TRAJ36, TRAJ37) have been corrected with the author's authorization (B.K.) in EMBL (11/97). These errors have not yet been corrected in AE000662 sequence.

Invariant TRAV10-TRAJ18 (previously Valpha24-JalphaQ), NK T rearrangements. The "invariant" TR alpha chain of the human CD161+ T cells which recognize CD1d results from the TRAV10-TRAJ18 (previously Valpha24-JalphaQ) rearrangement. CD161 is expressed by ~ 15 % of human T cells but only a very small fraction of these CD161+ T cells are invariant NK T cells (<0,1 % of total T cells and <1 % of CD161+ T cells in most donors) [Exley, M.A. et al., Current Protocols in Immunology, Wiley, J. and Sons, New York, 14, 14.11.1-14.11.13 (2002)].

Gene table of human (Homo sapiens) TRAJ IMGT group:
IMGT gene nameIMGT allele nameScore for
IMGT allele
confirmation		FctChromosomosal
localization		R T PrIMGT/LIGM-DB reference sequencesIMGT/LIGM-DB sequences from the literature
Clone namesAccession
numbers		Positions
in the sequence
(J-GENE-UNIT)
or J-REGION (*)		Secondary
accession
numbers		Clone namesAccession
numbers		Positions
in the sequence
(J-GENE-UNIT)
or J-REGION (*)
TRAJ1 TRAJ1*01 ORF (5) 14q11.2
RTPr
--
 X02884 [19] MAP 2336-2424 AE000662 [5,11] 51102-51189
CM000676.2 IMGT000024 [10,12] 933107-933195
CM089104.1 IMGT000290 [13] 933416-933504
J1 M94081 [11] 85207-85296
TRAJ2 TRAJ2*01 ORF (6) 14q11.2 X02884 [19] MAP 1369-1462 AE000662 [5,11] 50134-50227
CM000676.2 IMGT000024 [10,12] 932140-932233
CM089104.1 IMGT000290 [13] 932449-932542
J2 M94081 [11] 84241-84334
pseudoJalpha X05003 [2] 1713-1806
TRAJ3 TRAJ3*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 X02884 [19] MAP 476-565 AE000662 [5,11] 49241-49330
CM000676.2 IMGT000024 [10,12] 931248-931337
CM089104.1 IMGT000290 [13] 931556-931645
J3 M94081 [11] 83348-83437
JalphaSP X05003 [2] 821-910
TRAJ4 TRAJ4*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 J4 M94081 [11] MAP 82368-82458 AE000662 [5,11] 48261-48351
CM000676.2 IMGT000024 [10,12] 930268-930358
CM089104.1 IMGT000290 [13] 930576-930666
TRAJ5 TRAJ5*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 J5 M94081 [11] MAP 80416-80503 AE000662 [5,11] 46309-46396
CM000676.2 IMGT000024 [10,12] 928316-928403
CM089104.1 IMGT000290 [13] 928624-928711
TRAJ6 TRAJ6*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 JA5 M16747 [3] MAP 3-92 AE000662 [5,11] 45135-45224
CM000676.2 IMGT000024 [10,12] 927142-927231
CM089104.1 IMGT000290 [13] 927450-927539
J6 M94081 [11] 79242-79331
TRAJ7 TRAJ7*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 J7 M94081 [11] MAP 77795-77879 AE000662 [5,11] 43688-43772
CM000676.2 IMGT000024 [10,12] 925693-925777
CM089104.1 IMGT000290 [13] 926002-926086
TRAJ8 TRAJ8*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 J8 M94081 [11] 76318-76405 AE000662 [5,11] 42211-42298
CM089104.1 IMGT000290 [13] 924523-924610
TRAJ8 TRAJ8*02 P (1) 14q11.2 CM000676.2 IMGT000024 [10,12] MAP 924214-924301
TRAJ9 TRAJ9*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 J9 M94081 [11] MAP 75728-75816 AE000662 [5,11] 41621-41709
CM000676.2 IMGT000024 [10,12] 923623-923711
CM089104.1 IMGT000290 [13] 923932-924020
TRAJ10 TRAJ10*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 J10 M94081 [11] MAP 73671-73762 AE000662 [5,11] 39564-39655
CM000676.2 IMGT000024 [10,12] 921566-921657
CM089104.1 IMGT000290 [13] 921875-921966
TRAJ11 TRAJ11*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 J11 M94081 [11] MAP 72678-72765 AE000662 [5,11] 38571-38658
CM000676.2 IMGT000024 [10,12] 920571-920658
CM089104.1 IMGT000290 [13] 920880-920967
TRAJ12 TRAJ12*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 X02885 [19] MAP 25-112 AE000662 [5,11] 38008-38095
CM000676.2 IMGT000024 [10,12] 920008-920095
CM089104.1 IMGT000290 [13] 920317-920404
J12 M94081 [11] 72115-72202
TRAJ13 TRAJ13*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 J13 M94081 [11] 71252-71342 AE000662 [5,11] 37145-37235
TRAJ13 TRAJ13*02 F 14q11.2
R αT αPr αR δT δPr δ
++
 MLV-TPA-Mat-255 AB258131 [17] MAP complement(101-191) RP11-576P2 AC023226 [4] complement(51292-51382)
C-2555K7 AL160314 [9] <1-62 * (7)
CM000676.2 IMGT000024 [10,12] 919145-919235
CM089104.1 IMGT000290 [13] 919454-919544
JHAP23G X58764 [16] c(st) 73-135 *
TRAJ14 TRAJ14*01 F 14q11.2 J14 M94081 [11] MAP 70504-70583 AE000662 [5,11] 36397-36476
CM000676.2 IMGT000024 [10,12] 918396-918475
CM089104.1 IMGT000290 [13] 918706-918785
TRAJ15 TRAJ15*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 JaS X05775 [15] MAP 52-139 CM000676.2 IMGT000024 [10,12] 917698-917785
CM089104.1 IMGT000290 [13] 918008-918095
TRAJ15 TRAJ15*02 F 14q11.2
RTPr
++
 J15 M94081 [11] 69808-69895 AE000662 [5,11] P (14) 35699-35788
TRAJ16 TRAJ16*01 F (8) 14q11.2
R αT αPr αR δT δPr δ
++
 J16 M94081 [11] 68715-68802 AE000662 [5,11] 34606-34693
TRAJ16 TRAJ16*02 F (2) 14q11.2 CM000676.2 IMGT000024 [10,12] MAP 916596-916683 CM089104.1 IMGT000290 [13] 916906-916993
TRAJ17 TRAJ17*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 JaLv X05773 [15] MAP 145-235 AE000662 [5,11] 32931-33021
CM000676.2 IMGT000024 [10,12] 914913-915003
CM089104.1 IMGT000290 [13] 915223-915313
J17 M94081 [11] 67040-67130
TRAJ18 TRAJ18*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 J18 M94081 [11] MAP 65848-65941 AE000662 [5,11] 31739-31832
CM000676.2 IMGT000024 [10,12] 913719-913812
CM089104.1 IMGT000290 [13] 914031-914124
TRAJ19 TRAJ19*01 ORF (9) 14q11.2 J19 M94081 [11] MAP 65466-65548 AE000662 [5,11] 31357-31439
CM000676.2 IMGT000024 [10,12] 913337-913419
CM089104.1 IMGT000290 [13] 913649-913731
TRAJ20 TRAJ20*01 F 14q11.2
R αT αPr αR δT δPr δ
++-
 J20 M94081 [11] MAP 64525-64608 AE000662 [5,11] 30416-30499
CM000676.2 IMGT000024 [10,12] 912394-912478
CM089104.1 IMGT000290 [13] 912706-912790
TRAJ21 TRAJ21*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 J21 M94081 [11] MAP 63801-63883 AE000662 [5,11] 29692-29774
CM000676.2 IMGT000024 [10,12] 911669-911751
CM089104.1 IMGT000290 [13] 911981-912063
TRAJ22 TRAJ22*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 J22 X02886 [19] MAP 377-467 AE000662 [5,11] 28135-28225
CM000676.2 IMGT000024 [10,12] 910109-910199
CM089104.1 IMGT000290 [13] 910420-910511
J22 M94081 [11] 62244-62334
TRAJ23 TRAJ23*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 J23 M94081 [11] MAP 60622-60712 AE000662 [5,11] 26513-26603
CM000676.2 IMGT000024 [10,12] 908485-908575
CM089104.1 IMGT000290 [13] 908797-908887
TRAJ23 TRAJ23*02 F 14q11.2 JHAP36G X58763 [16] c(st) 61-123 *
TRAJ24 TRAJ24*01 F 14q11.2 X02887 [19] 96-186
TRAJ24 TRAJ24*02 F 14q11.2
R αT αPr αR δT δPr δ
++
 M94081 [11] 60175-60265 AE000662 [5,11] 26066-26156
CM089104.1 IMGT000290 [13] 908350-908440
TRAJ24 TRAJ24*03 F 14q11.2 CM000676.2 IMGT000024 [10,12] MAP 908038-908128
TRAJ25 TRAJ25*01 ORF (10) 14q11.2 X02888 [19] MAP 7-94 AE000662 [5,11] 24909-24996
CM000676.2 IMGT000024 [10,12] 906881-906968
CM089104.1 IMGT000290 [13] 907193-907280
J25 M94081 [11] 59018-59105
TRAJ26 TRAJ26*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 J26 M94081 [11] MAP 58652-58739 AE000662 [5,11] 24543-24630
CM000676.2 IMGT000024 [10,12] 906515-906602
CM089104.1 IMGT000290 [13] 906827-906914
TRAJ27 TRAJ27*01 F 14q11.2
R αT αPr αR δT δPr δ
++-
 J27 M94081 [11] MAP 56479-56565 AE000662 [5,11] 22370-22456
CM000676.2 IMGT000024 [10,12] 904342-904428
CM089104.1 IMGT000290 [13] 904654-904740
TRAJ28 TRAJ28*01 F 14q11.2
R αT αPr αR δT δPr δ
++-
 J28 M94081 [11] MAP 55829-55922 AE000662 [5,11] 21720-21813
CM000676.2 IMGT000024 [10,12] 903692-903785
CM089104.1 IMGT000290 [13] 904004-904097
TRAJ29 TRAJ29*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 J29 M94081 [11] MAP 54149-54236 AE000662 [5,11] 20040-20127
CM000676.2 IMGT000024 [10,12] 902008-902095
CM089104.1 IMGT000290 [13] 902321-902408
X02889 [19] <1-59 *
TRAJ30 TRAJ30*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 J30 M94081 [11] MAP 53062-53146 AE000662 [5,11] 18953-19037
CM000676.2 IMGT000024 [10,12] 900921-901005
CM089104.1 IMGT000290 [13] 901234-901318
TRAJ31 TRAJ31*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 J31 M94081 [11] MAP 51179-51263 AE000662 [5,11] 17070-17154
CM000676.2 IMGT000024 [10,12] 899037-899121
CM089104.1 IMGT000290 [13] 899350-899434
M14905 [8] 49-132
TRAJ32 TRAJ32*01 F 14q11.2
RTPr
++
 J32 M94081 [11] 49553-49646 AE000662 [5,11] 15444-15537
TRAJ32 TRAJ32*02 F 14q11.2
R αT αPr αR δT δPr δ
++
 CM000676.2 IMGT000024 [10,12] MAP 897410-897503 AF532854 [14] #c 240-298 *
CM089104.1 IMGT000290 [13] 897724-897817
TRAJ33 TRAJ33*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 J33 M94081 [11] MAP 48815-48899 AE000662 [5,11] 14706-14790
CM000676.2 IMGT000024 [10,12] 896671-896755
CM089104.1 IMGT000290 [13] 896985-897069
TRAJ34 TRAJ34*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 JaAB M35622 [1] MAP 2-87 AE000662 [5,11] 13770-13855
CM000676.2 IMGT000024 [10,12] 895735-895820
CM089104.1 IMGT000290 [13] 896049-896134
J34 M94081 [11] 47879-47964
TRAJ35 TRAJ35*01 F (3) 14q11.2
R αT αPr αR δT δPr δ
-+-
 J35 M94081 [11] MAP 46857-46943 AE000662 [5,11] 12748-12834
CM000676.2 IMGT000024 [10,12] 894713-894799
CM089104.1 IMGT000290 [13] 895013-895099
TRAJ36 TRAJ36*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 J36 M94081 [11] MAP 45325-45411 AE000662 [5,11] 11215-11302
CM000676.2 IMGT000024 [10,12] 893179-893265
CM089104.1 IMGT000290 [13] 893479-893565
TRAJ37 TRAJ37*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 J37 M94081 [11] 43965-44054 AE000662 [5,11] P (15) 9854-9944
TRAJ37 TRAJ37*02 F 14q11.2
R αT αPr αR δT δPr δ
++
 CM000676.2 IMGT000024 [10,12] MAP 891819-891908 AJ007774 [18] #c 336-396 *
CM089104.1 IMGT000290 [13] 892097-892186
TRAJ38 TRAJ38*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 J38 M94081 [11] MAP 42445-42534 AE000662 [5,11] 8334-8423
CM000676.2 IMGT000024 [10,12] 890300-890389
CM089104.1 IMGT000290 [13] 890578-890667
TRAJ39 TRAJ39*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 J39 M94081 [11] MAP 41815-41905 AE000662 [5,11] 7704-7794
CM000676.2 IMGT000024 [10,12] 889670-889760
CM089104.1 IMGT000290 [13] 889948-890038
TRAJ40 TRAJ40*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 JaAA M35620 [1] MAP 7-95 AE000662 [5,11] 5791-5879
CM000676.2 IMGT000024 [10,12] 887758-887846
CM089104.1 IMGT000290 [13] 888036-888124
J40 M94081 [11] 39902-39990
TRAJ41 TRAJ41*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 J41 M94081 [11] MAP 37872-37961 AE000662 [5,11] 3761-3850
CM000676.2 IMGT000024 [10,12] 885726-885815
CM089104.1 IMGT000290 [13] 886004-886093
TRAJ42 TRAJ42*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 J42 M94081 [11] MAP 37102-37195 AE000662 [5,11] 2991-3084
CM000676.2 IMGT000024 [10,12] 884956-885049
CM089104.1 IMGT000290 [13] 885234-885327
TRAJ43 TRAJ43*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 J43 M94081 [11] MAP 36126-36207 AE000662 [5,11] 2015-2096
CM000676.2 IMGT000024 [10,12] 883982-884063
CM089104.1 IMGT000290 [13] 884260-884341
TRAJ44 TRAJ44*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 JaRP M35619 [1] MAP 2-92 AE000662 [5,11] 925-1015
CM000676.2 IMGT000024 [10,12] 882890-882980
CM089104.1 IMGT000290 [13] 883168-883258
J44 M94081 [11] 35036-35126
TRAJ45 TRAJ45*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 J45 M94081 [11] MAP 34141-34234 AE000662 [5,11] 30-123
CM000676.2 IMGT000024 [10,12] 881994-882087
CM089104.1 IMGT000290 [13] 882272-882365
TRAJ46 TRAJ46*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 J46 M94081 [11] MAP 33619-33709 AE000661 [5,11] 247327-247417
CM000676.2 IMGT000024 [10,12] 881472-881562
CM089104.1 IMGT000290 [13] 881750-881840
TRAJ47 TRAJ47*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 J47 M94081 [11] MAP 33068-33152 AE000661 [5,11] 246776-246860
CM000676.2 IMGT000024 [10,12] 880920-881004
CM089104.1 IMGT000290 [13] 881198-881282
TRAJ47 TRAJ47*02 (F) 14q11.2
R αT αPr αR δT δPr δ
++
 AF033825 [7] #c 312-367 *
TRAJ48 TRAJ48*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 J48 M94081 [11] MAP 30709-30799 AE000661 [5,11] 244417-244507
CM000676.2 IMGT000024 [10,12] 878560-878650
CM089104.1 IMGT000290 [13] 878838-878928
TRAJ49 TRAJ49*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 J49 M94081 [11] MAP 29706-29789 AE000661 [5,11] 243416-243497
CM000676.2 IMGT000024 [10,12] 877557-877640
CM089104.1 IMGT000290 [13] 877835-877918
TRAJ50 TRAJ50*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 J50 M94081 [11] MAP 28811-28898 AE000661 [5,11] 242519-242606
CM000676.2 IMGT000024 [10,12] 876662-876749
CM089104.1 IMGT000290 [13] 876940-877027
TRAJ51 TRAJ51*01 P (11) 14q11.2
RTPr
--
 J51 M94081 [11] MAP 27401-27491 AE000661 [5,11] 241109-241199
CM000676.2 IMGT000024 [10,12] 875252-875342
CM089104.1 IMGT000290 [13] 875530-875620
TRAJ52 TRAJ52*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 J52 M94081 [11] MAP 26446-26542 AE000661 [5,11] 240154-240250
CM000676.2 IMGT000024 [10,12] 874297-874393
CM089104.1 IMGT000290 [13] 874575-874671
TRAJ53 TRAJ53*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 J53 M94081 [11] MAP 23223-23316 AE000661 [5,11] 236931-237024
CM000676.2 IMGT000024 [10,12] 871073-871166
CM089104.1 IMGT000290 [13] 871351-871444
TRAJ54 TRAJ54*01 F 14q11.2
R αT αPr αR δT δPr δ
++-
 J54 M94081 [11] MAP 22506-22593 AE000661 [5,11] 236214-236301
CM000676.2 IMGT000024 [10,12] 870356-870443
CM089104.1 IMGT000290 [13] 870634-870721
TRAJ55 TRAJ55*01 P (11) 14q11.2 J55 M94081 [11] MAP 21916-22000 AE000661 [5,11] 235624-235708
CM000676.2 IMGT000024 [10,12] 869766-869850
CM089104.1 IMGT000290 [13] 870044-870128
TRAJ56 TRAJ56*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 J56 M94081 [11] MAP 19740-19829 AE000661 [5,11] 233448-233537
CM000676.2 IMGT000024 [10,12] 867590-867679
CM089104.1 IMGT000290 [13] 867868-867957
TRAJ57 TRAJ57*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 J57 M94081 [11] MAP 19091-19181 AE000661 [5,11] 232799-232889
CM000676.2 IMGT000024 [10,12] 866941-867031
CM089104.1 IMGT000290 [13] 867219-867309
TRAJ58 TRAJ58*01 ORF (12) 14q11.2
R αT αPr αR δT δPr δ
++
 J58 M94081 [11] MAP 17926-18016 AE000661 [5,11] 231634-231724
CM000676.2 IMGT000024 [10,12] 865776-865866
CM089104.1 IMGT000290 [13] 866054-866144
TRAJ59 TRAJ59*01 ORF (4) 14q11.2
RTPr
+--
 J59 M94081 [11] MAP 16773-16860 AE000661 [5,11] 230472-230568
CM000676.2 IMGT000024 [10,12] 864622-864709
CM089104.1 IMGT000290 [13] 864900-864987
TRAJ60 TRAJ60*01 P (11) 14q11.2
RTPr
+
 J60 M94081 [11] MAP 16526-16610 AE000661 [5,11] 230234-230318
CM000676.2 IMGT000024 [10,12] 864375-864459
CM089104.1 IMGT000290 [13] 864653-864737
TRAJ61 TRAJ61*01 ORF (13) 14q11.2
RTPr
+
 J61 M94081 [11] MAP 15536-15623 AE000661 [5,11] 229244-229331
CM000676.2 IMGT000024 [10,12] 863385-863472
CM089104.1 IMGT000290 [13] 863663-863750
IMGT notes: ↑
  1. STOP-CODON in J-REGION
  2. noncanonical J-MOTIF: FAXG instead FGXG however Ala and Gly are both very small amino acids, this change does not pose a structural problem
  3. noncanonical J-MOTIF: Cys-Gly-X-Gly instead of Phe-Gly-X-Gly, however this J-GENE has been found rearranged and expressed in several specific cDNA clones
  4. Defective DONOR-SPLICE t/ct instead of n/gt
  5. Non canonical J-HEPTAMER: GGGCATG instead of CACTGTG, and non canonical J-NONAMER: ATTCTGT instead of GGTTTTTGT.
  6. Non canonical J-HEPTAMER: TACGGTA instead of CACTGTG.
  7. Partial J-REGION in 5' side.
  8. Note in the J-REGION: Phe-Ala-X-Gly instead of Phe-Gly-X-Gly, however Ala and Gly are both very small amino acids, this change does not pose a structural problem
  9. unexpected J-SPACER length (7 nt instead of 12 nt), noncanonical J-NONAMER: tgattttgc instead of ggtttttgt and noncanonical J-HEPTAMER: agatgtg instead of cactgtg.
  10. Non canonical J-HEPTAMER: CACTATG instead of CACTGTG.
  11. STOP-CODON in J-REGION.
  12. Note that the first codon of the germline J-REGION is a STOP-CODON which may disappear during rearrangements.
  13. Defective DONOR-SPLICE t/ct instead of n/gt.
  14. frameshifts due to 2 DELETIONs:typing errors, corrected in M94081
  15. frameshift in J-REGION:typing error (corrected in M94081
IMGT references: ↑
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  2. Baer R. et al., Organization of the T-cell receptor alpha-chain gene and rearrangement in human T-cell leukaemias, Mol. Biol. Med, vol. 3, no. 3, 1986, pp. 265-277. PUBMED: 3016457
  3. Baer R. et al., The mechanism of chromosome 14 inversion in a human T cell lymphoma, Cell, vol. 50, no. 1, 1987, pp. 97-105. DOI: 10.1016/0092-8674(87)90666-0
  4. Birren B. et al., Homo sapiens chromosome 14, clone RP11-576P2, Unpublished.
  5. Boysen C. et al., Analysis of the 1.1-Mb human alpha/delta T-cell receptor locus with bacterial artificial chromosome clones, Genome Res, vol. 7, no. 4, 1997, pp. 330-338. PUBMED: 9110172
  6. Boysen C. et al., T-Cell Receptor Alpha Delta Locus Complete Nucleotide Sequence, Unpublished.
  7. Brander C. et al., Persistence of clonal TCR responses in chronic pediatric HIV-1 infection, Unpublished.
  8. Finger L.R. et al., A common mechanism of chromosomal translocation in T- and B-cell neoplasia, Science, vol. 234, no. 4779, 1986, pp. 982-985. PUBMED: 3490692
  9. Heilig R. et al., Sequencing of the human chromosome 14, Unpublished.
  10. Heilig R. et al., The DNA sequence and analysis of human chromosome 14, Nature, vol. 421, no. 6923, 2003, pp. 601-607. PUBMED: 12508121
  11. Koop B.F. et al., The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA, Genomics, vol. 19, no. 3, 1994, pp. 478-493. DOI: 10.1006/geno.1994.1097
  12. Lander,E.S. et al., Initial sequencing and analysis of the human genome, Nature, vol. 409, no. 6822, 2001, pp. 860-921. PUBMED: 11237011
  13. Liao W.W. et al., A draft human pangenome reference, Nature, vol. 617, no. 7960, 2023, pp. 312-324. PUBMED: 37165242
  14. Mantovani S, Dominant T cell receptor (TCR) alpha requirements for a self antigen recognition in humans, Unpublished.
  15. Mengle-Gaw L. et al., Human T-cell tumours containing chromosome 14 inversion or translocation with breakpoints proximal to immunoglobulin joining regions at 14q32, EMBO J, vol. 6, no. 8, 1987, pp. 2273-2280. PUBMED: 3117531
  16. Roman-Roman S. et al., Studies on the human T cell receptor alpha/beta variable region genes. I. Identification of 7 additional V alpha subfamilies and 14 J alpha gene segments, Eur. J. Immunol, vol. 21, no. 4, 1991, pp. 927-933. PUBMED: 1826888
  17. Tsukahara T. et al., Murine leukemia virus vector integration favors promoter regions and regional hot spots in a human T-cell line, Biochem. Biophys. Res. Commun, vol. 345, no. 3, 2006, pp. 1099-1107. DOI: 10.1016/j.bbrc.2006.05.007
  18. Wienhold W. et al., A dominant T cell epitope is recognized by invariant CDR3 beta engagement of synonymous T cell receptors, Unpublished.
  19. Yoshikai Y. et al., Organization and sequences of the variable, joining and constant region genes of the human T-cell receptor alpha-chain, Nature, vol. 316, no. 6031, 1985, pp. 837-840. DOI: 10.1038/316837a0