Citing IMGT dynamic tools: Sanou G., Zeitoun G. et al. IMGT® at scale: FAIR, Dynamic and Automated Tools for Immune Locus Analysis, Nucleic Acids Research. 2025;,gkaf1024. doi: 10.1093/nar/gkaf1024 (Free Article) PMID: 41091930.
Program version: v. 

Add information about removed genes/alleles.
May 15th, 2025.

Add the possibility to obtain a gene table per strain (for mouse now and for other species later) and allotypes/isotypes for human.
September 25th, 2024.

Bibliographical references in alphabetic order, small design changes and addition of "NL" for non-localized gene.
June 14th, 2024.

Addition of 'Score for IMGT allele confirmation' as well as NCBI TPA accession numbers.
September 20th, 2023.

Implementation of the dynamic gene table.

Gene table legend:

"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene, when the data have been confirmed by several studies.

Functionality is shown in parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.

IMGT allele confirmation: A scoring system is employed to indicate the number of IMGT/LIGM-DB reference sequences and other sequences from the literature in which an IG or TR gene allele has been identified and annotated.

Removed genes/alleles
If a gene/allele existence or name has to be changed, the old name or gene/allele would be deleted and its name won't be reused. They are kept in the gene table for historical reasons.
A single star ()
indicates that an IG or TR gene allele is annotated in the reference sequence only.
Two stars ()
indicate that an IG or TR gene allele is annotated in its reference sequence and in one sequence from the literature.
Three stars ()
indicate that an IG or TR gene allele is annotated in its reference sequence and in at least two sequences from the literature.
In the Excel file, the stars are represented by the plus symbol (+).

Click on:
  • IMGT gene name to get the corresponding IMGT/GENE-DB entry (link).
  • IMGT allele name to see the corresponding Alignments of alleles (link).
  • Accession number to get the corresponding IMGT/LIGM-DB entry (link).
  • MAP: mapped sequences. Click to access GENE-DB «LOCALIZATION IN GENOME ASSEMBLIES» (link).
  • [number] to access the corresponding IMGT reference (popover).
  • (number) to see the corresponding IMGT note (popover).
Options:
  • You can show/hide columns (), download data () or put the table in fullscreen () using buttons.
See also (IMGT Scientific chart):
Select a species and a IMGT group to get the gene table:
Only IMGT available species/group are shown in the drop-down list.
The gene table can take several seconds to appear, please be patient.

Although the TRDV1 gene was also found rearranged to a TRAJ gene and therefore expressed with the TRAC gene [12,13] (Assignment of rearranged cDNAs), it is considered as a TRDV gene. The first five Homo sapiens TRAV genes found rearranged, not only as expected to TRAJ but also to TRDD-TRDJ genes and with the designation TRAV/DV are reported in the Gene table: Human (Homo sapiens) TRAV. They include Homo sapiens TRAV14/DV4, TRAV29/DV5, TRAV23/DV6, TRAV36/DV7 and TRAV38-2/DV8 genes.

Gene table of human (Homo sapiens) TRDV IMGT group:
IMGT sub­groupIMGT gene nameIMGT allele nameScore for
IMGT allele
confirmation		FctChromosomosal
localization		R T PrIMGT/LIGM-DB reference sequencesIMGT/LIGM-DB sequences from the literature
Clone namesAccession
numbers		Positions
in the sequence
(L-V-GENE-UNIT)
or V-REGION (*)		Secondary
accession
numbers		Clone namesAccession
numbers		Positions
in the sequence
(L-V-GENE-UNIT)
or V-REGION (*)
TRDV1TRDV1 TRDV1*01 F 14q11.2
RTPr
++
 Vdelta1 M22198 [25] MAP 80-688 DV101S1 AE000660 [1,3,14] 100359-100967
CM000676.2 IMGT000024 [8,15] 484147-484755
CM089104.1 IMGT000290 [17] 483832-484440
DV101S1 U32547 [2] (1) 15->501
TRDV2TRDV2 TRDV2*01 F 14q11.2
RTPr
++
 V2*A1 X15207 [4] (2) 1-534
TRDV2TRDV2 TRDV2*01 F 14q11.2
RTPr
++
 V2*A1 X15275 [5] (3) Unknown CM089104.1 IMGT000290 [17] 810893-811428
DV102S1 U32548 [2] (1) <1->216 *
TRDV2TRDV2 TRDV2*02 F 14q11.2 V2*A2 Y13426 [30] (1) <1->283 *
TRDV2TRDV2 TRDV2*03 F 14q11.2
RTPr
++
 DV102S1 AE000661 [1,3,14] MAP 176503-177038 CM000676.2 IMGT000024 [8,15] 810643-811178
Vdelta2 X53849 [27] #c 87-374 *
TRDV3 (18)TRDV3 (18) TRDV3*01 F 14q11.2
RTPr
++
 V3 M23326 [18] MAP 19-630 DV103S1 AE000661 [1,3,14] (4) complement(222960-223572)
CM000676.2 IMGT000024 [8,15] complement(857099-857711)
CM089104.1 IMGT000290 [17] complement(857390-858001)
M94081 [14] (4) complement(9256-9868)
DV103S1 U32549 [2] (1,5) 18->531
Vdelta3 X13954 [7] 107-718
TRDV3 (18)TRDV3 (18) TRDV3*02 F 14q11.2 Vdelta3 X15261 [26] 32-643
TRDV4TRAV14/DV4 TRAV14/DV4*01 F 14q11.2
RTPr
++
 M21626 [6] MAP 1-554 CM000676.2 IMGT000024 [8,15] 312235-312787
CM089104.1 IMGT000290 [17] 311888-312440
TRDV4TRAV14/DV4 TRAV14/DV4*02 F 14q11.2
RTPr
++
 hADV14S1 AE000659 [1,3,14] 179487-180039 S51029 [29] (6) #c 61->349 *
TRDV4TRAV14/DV4 TRAV14/DV4*03 (F) 14q11.2
RTPr
++
 M21624 [6] #c 131-412 *
TRDV4TRAV14/DV4 TRAV14/DV4*04 [F] 14q11.2
RTPr
++
 AV06S1 L09758 [22] (7) ° <1->271 *
TRDV5TRAV29/DV5 TRAV29/DV5*01 F 14q11.2
RTPr
++
 hADV29S1 AE000660 [1,3,14] 167277-167837 M15565 [16] #c 187-463 *
TRDV5TRAV29/DV5 TRAV29/DV5*02 F 14q11.2 Valpha21a S81645 [28] (8) c(st) 174-452 *
TRDV5TRAV29/DV5 TRAV29/DV5*03 P (9) 14q11.2 Valpha21c AJ245565 [28] 381-659 *
TRDV5TRAV29/DV5 TRAV29/DV5*04 F 14q11.2 CM000676.2 IMGT000024 [8,15] MAP 551446-552006 CM089104.1 IMGT000290 [17] 551140-551700
TRDV6TRAV23/DV6 TRAV23/DV6*01 F 14q11.2
RTPr
++
 hADV23S1 AE000660 [1,3,14] 90761-91309 CM089104.1 IMGT000290 [17] 474235-474783
Valpha13.1 M22936 [25] (10,11) <1-176 *
AV17S1 U32526 [2] (12) ° 159->405 *
Valpha17b X70309 [20] (13) #c 130-402 *
TRDV6TRAV23/DV6 TRAV23/DV6*02 (F) 14q11.2
RTPr
++
 Valpha13.1 M17660 [13] #c 85-364 * Valpha13.1 M22936 [25] (10,11) <1-176 *
TRDV6TRAV23/DV6 TRAV23/DV6*03 (F) 14q11.2
RTPr
++
 Valpha17.1-V M97704 [9] #c 145-424 * AV17S1 Z49057 [10] (14) <1->267 *
TRDV6TRAV23/DV6 TRAV23/DV6*04 [F] 14q11.2 Y10411 [11] (14) ° <1->267 *
TRDV6TRAV23/DV6 TRAV23/DV6*05 F 14q11.2 CM000676.2 IMGT000024 [8,15] MAP 474549-475097
TRDV7TRAV36/DV7 TRAV36/DV7*01 F 14q11.2
RTPr
++
 hADV36S1 AE000660 [1,3,14] 230689-231220
TRDV7TRAV36/DV7 TRAV36/DV7*02 (F) 14q11.2
RTPr
++
 Valphaw28 X61070 [23] #c 7-280 *
TRDV7TRAV36/DV7 TRAV36/DV7*03 (F) 14q11.2
RTPr
++
 Valphaw28 X58767 [24] (13) #c 109->378 *
TRDV7TRAV36/DV7 TRAV36/DV7*04 (F) 14q11.2
RTPr
++
 Vdelta7 Z46643 [19,24] (13) #c 87-357 * AV28S1 U32536 [2] (15) ° 203->456 *
TRDV7TRAV36/DV7 TRAV36/DV7*05 F 14q11.2 CM000676.2 IMGT000024 [8,15] 614859-615390 CM089104.1 IMGT000290 [17] 614560-615091
TRDV8TRAV38-2/DV8 TRAV38-2/DV8*01 F 14q11.2
RTPr
++
 hADV38S2 AE000661 [1,3,14] MAP 34000-34636 CM000676.2 IMGT000024 [8,15] 669248-669884
CM089104.1 IMGT000290 [17] 668958-669594
AV14S1 U32524 [2] (16) ° 180->330 *
Valpha14.2 X58158 [21] (17) 678->837 *
Valpha14.1 Z29614 [12] #c 103-388 *
Vdelta8 Z46644 [19] #g 330-618 *
IMGT notes: ↑
  1. V-REGION is partial.
  2. These sequences overlap by 4 nucleotides including the INIT-CODON ATG.
  3. 5'UTR of the gene.
  4. Reverse and complement V-GENE. See note (5).
  5. The t243>c and c244>t substitutions (inversion of two nucleotides) in U32549 EMBL flat file are probably typing errors.
  6. Rearranged CDR3-IMGT is partial.
  7. V-REGION is partial: AA 1 is missing (partial FR1-IMGT), and AA 104 is missing (partial FR3-IMGT, and no CDR3-IMGT).
  8. This gene is a sterile transcript. It has been found with a leader L region and a germline V region. L-V-sequence is in germline configuration.
  9. DELETION of one nucleotide leading to a frameshift.
  10. V-REGION is partial: AA 1 to 42 are missing (part ial FR2-IMGT), and no FR1-IMGT.
  11. Partial sequences which could not be assigned to a given allele.
  12. V-REGION is partial: AA 97 to 104 are missing (partial FR3-IMGT), and no CDR3-IMGT.
  13. CDR3-IMGT is partial: only amino acid 105 is present.
  14. V-REGION is partial: AA 1 is missing (partial FR1-IMGT), and no CDR3-IMGT.
  15. V-REGION is partial: AA 100 to 104 are missing (partial FR3-IMGT), and no CDR3-IMGT.
  16. V-REGION is partial: AA 56 to 104 are missing (partial CDR2-IMGT), no FR3-IMGT and no CDR3-IMGT.
  17. V-REGION is partial: AA 59 to 104 are missing (partial CDR2-IMGT), no FR3-IMGT, and no CDR3-IMGT.
  18. The TRDV3 gene is localized in 3' from the TRDC gene and is in inverted orientation of transcription. Due to its polarity opposite to the TRD D-J-C-CLUSTER, TRDV3 rearranges by an inversional joining [2, 5, 6].
IMGT references: ↑
  1. Boysen C. et al., Analysis of the 1.1-Mb human alpha/delta T-cell receptor locus with bacterial artificial chromosome clones, Genome Res, vol. 7, no. 4, 1997, pp. 330-338. PUBMED: 9110172
  2. Boysen C. et al., Identifying DNA polymorphisms in human TCRA/D variable genes by direct sequencing of PCR products, Immunogenetics, vol. 44, no. 2, 1996, pp. 121-127. DOI: 10.1007/s002510050099
  3. Boysen C. et al., T-Cell Receptor Alpha Delta Locus Complete Nucleotide Sequence, Unpublished.
  4. Dariavach P. and Lefranc M.P, First genomic sequence of the human T-cell receptor delta 2 gene (TRDV2), Nucleic Acids Res, vol. 17, no. 12, 1989, pp. 4880-4880. DOI: 10.1093/nar/17.12.4880
  5. Dariavach P. and Lefranc M.P, The promoter regions of the T-cell receptor V9 gamma (TRGV9) and V2 delta (TRDV2) genes display short direct repeats but no TATA box, FEBS Lett, vol. 256, no. 1-2, 1989, pp. 185-191. DOI: 10.1016/0014-5793(89)81745-4
  6. Guglielmi P. et al., Use of a variable alpha region to create a functional T-cell receptor delta chain, Proc. Natl. Acad. Sci. U.S.A, vol. 85, no. 15, 1988, pp. 5634-5638. DOI: 10.1073/pnas.85.15.5634
  7. Hata S. et al., Diversity and organization of human T cell receptor delta variable gene segments, J. Exp. Med, vol. 169, no. 1, 1989, pp. 41-57. DOI: 10.1084/jem.169.1.41
  8. Heilig R. et al., The DNA sequence and analysis of human chromosome 14, Nature, vol. 421, no. 6923, 2003, pp. 601-607. PUBMED: 12508121
  9. Hurley C.K. et al., Nonrandom T cell receptor usage in the allorecognition of HLA-DR1 microvariation, J. Immunol, vol. 150, no. 4, 1993, pp. 1314-1324. PUBMED: 8381833
  10. Ibberson M.R. et al., Genomic organization of the human T-cell receptor variable alpha (TCRAV) gene cluster, Genomics, vol. 28, no. 2, 1995, pp. 131-139. DOI: 10.1006/geno.1995.1123
  11. Ibberson M.R. et al., T-cell receptor variable alpha (TCRAV) polymorphisms in European, Chinese, South American, AfroCaribbean, and Gambian populations, Immunogenetics, vol. 47, no. 2, 1998, pp. 124-130. DOI: 10.1007/s002510050337
  12. Kalams S.A. et al., Longitudinal analysis of T cell receptor (TCR) gene usage by human immunodeficiency virus 1 envelope-specific cytotoxic T lymphocyte clones reveals a limited TCR repertoire, J. Exp. Med, vol. 179, no. 4, 1994, pp. 1261-1271. DOI: 10.1084/jem.179.4.1261
  13. Klein M.H. et al., Diversity and structure of human T-cell receptor alpha-chain variable region genes, Proc. Natl. Acad. Sci. U.S.A, vol. 84, no. 19, 1987, pp. 6884-6888. DOI: 10.1073/pnas.84.19.6884
  14. Koop B.F. et al., The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA, Genomics, vol. 19, no. 3, 1994, pp. 478-493. DOI: 10.1006/geno.1994.1097
  15. Lander,E.S. et al., Initial sequencing and analysis of the human genome, Nature, vol. 409, no. 6822, 2001, pp. 860-921. PUBMED: 11237011
  16. Leiden J.M. et al., The complete primary structure of the T-cell receptor genes from an alloreactive cytotoxic human T-lymphocyte clone, Immunogenetics, vol. 24, no. 1, 1986, pp. 17-23. DOI: 10.1007/BF00372293
  17. Liao W.W. et al., A draft human pangenome reference, Nature, vol. 617, no. 7960, 2023, pp. 312-324. PUBMED: 37165242
  18. Loh E.Y. et al., Human T-cell-receptor delta chain: genomic organization, diversity, and expression in populations of cells, Proc. Natl. Acad. Sci. U.S.A, vol. 85, no. 24, 1988, pp. 9714-9718. PUBMED: 2974163
  19. Migone N. et al., Restriction of the T-cell receptor V delta gene repertoire is due to preferential rearrangement and is independent of antigen selection, Immunogenetics, vol. 42, no. 5, 1995, pp. 323-332. DOI: 10.1007/BF00179393
  20. Plaza A. et al., Unpublished.
  21. Pluschke G. et al., Biased T cell receptor V alpha region repertoire in the synovial fluid of rheumatoid arthritis patients, Eur. J. Immunol, vol. 21, no. 11, 1991, pp. 2749-2754. PUBMED: 1657615
  22. Reyburn H.T. et al., Allelic polymorphism of human T-cell receptor V alpha gene segments, Immunogenetics, vol. 38, no. 4, 1993, pp. 287-291. DOI: 10.1007/BF00188806
  23. Roman-Roman S. et al., Alternatively spliced T cell receptor transcripts expressed in human T lymphocytes, Mol. Immunol, vol. 30, no. 5, 1993, pp. 423-431. DOI: 10.1016/0161-5890(93)90110-W
  24. Roman-Roman S. et al., Studies on the human T cell receptor alpha/beta variable region genes. I. Identification of 7 additional V alpha subfamilies and 14 J alpha gene segments, Eur. J. Immunol, vol. 21, no. 4, 1991, pp. 927-933. PUBMED: 1826888
  25. Satyanarayana K. et al., Genomic organization of the human T-cell antigen-receptor alpha/delta locus, Proc. Natl. Acad. Sci. U.S.A, vol. 85, no. 21, 1988, pp. 8166-8170. PUBMED: 3186718
  26. Takihara Y. et al., Organization and orientation of a human T cell receptor delta chain V gene segment that suggests an inversion mechanism is utilized in its rearrangement, Eur. J. Immunol, vol. 19, no. 3, 1989, pp. 571-574. PUBMED: 2523312
  27. Triebel F. et al., A novel human V delta gene expressed predominantly in the Ti gamma A fraction of gamma/delta+ peripheral lymphocytes, Eur. J. Immunol, vol. 18, no. 12, 1988, pp. 2021-2027. PUBMED: 2975601
  28. Wright J.A. et al., Human T-cell receptor V alpha gene polymorphism, Hum. Immunol, vol. 32, no. 4, 1991, pp. 277-283. DOI: 10.1016/0198-8859(91)90091-M
  29. Yassai M. et al., Analysis of human T-cell receptor alpha-chain cDNAs isolated from peripheral blood mononuclear cells, Hum. Immunol, vol. 34, no. 4, 1992, pp. 279-283. DOI: 10.1016/0198-8859(92)90027-K
  30. Zhang X.M. and Lefranc M.P, PCR-based detection of one BamHI polymorphic site in the human T cell receptor delta gene TCRDV2, Hum. Genet, vol. 92, no. 1, 1993, pp. 100-100. DOI: 10.1007/BF00216155