Human (Homo sapiens) TRD locus on chromosome 14
- The human (Homo sapiens) TRD locus is on chromosome 14q11.2.
The orientation of the locus is forward (FWD).
-
The human (Homo sapiens) TRA/TRD locus spans 950 kilobases (kb), from 10 kb upstream of the most 5' gene in the locus, TRAV1-1 (F),
to 10 kb downstream of the most 3' gene in the locus, TRAC (F). The Locus representation encompasses 1000 kb, including the 3' borne DAD1.
- The human (Homo sapiens) TRD locus consists of 16 genes:
8 TRDV belonging to 8 subgroups, 3 TRDD, 4 TRDJ and a unique TRDC gene.
- The TRDV genes span 102 kilobases (kb), the TRDD genes span 22 kilobases (kb), the TRDJ genes span 11 kilobases (kb)
and the TRDC gene spans 6 kilobases (kb).
Clusters
- The TRDV genes are localized in 2 V-CLUSTER:
- The 5' V-CLUSTER, classically in 5' of the TRDD, TRDJ and
TRDC, includes 7 TRDV genes belonging to 7 subgroups.
- The 3' V-CLUSTER, downstream of the TRDC in inverted
orientation, includes 1 TRDV gene.
- The TRDD, TRDJ and TRDC genes are localized in one
D-J-C-CLUSTER between the 5' V-CLUSTER and the 3' V-CLUSTER:
- The CLUSTER includes 3 TRDD, 4 TRDJ and 1 TRDC functional .
Bornes of the human (Homo sapiens) TRA/TRD locus on chromosome 14
- No 5' borne conserved between species has been identified upstream of TRAV1-1 (F), the most 5' gene in the locus, according to the IMGT reference. However, OR10G3 (5' borne) has been identified 32 kb upstream of TRAV1-1 (F) in HG_01123_mat_hprc_f2 assembly.
- DAD1 (3' borne) has been identified 13 kb downstream of TRAC (F), the most 3' gene in the locus.
- Created:
- 07/11/2025
- Last updated:
- 07/11/2025 20:11
- Author:
- Mia Cherkaoui
