Pig (Sus scrofa) TRB locus on chromosome 18
- The pig (Sus scrofa) TRB locus is on chromosome 18.
The orientation of the locus is reverse (REV).
- The pig (Sus scrofa) TRB locus spans 356 kilobases (kb),
from 10 kb upstream of the most 5' gene in the locus, TRBV1 (F), to 10 kb
downstream of the most 3' gene in the locus, TRBV30 (F).
The Locus representation
encompasses 400 kb including the 5' borne MOXD2 and the 3' borne EPHB6.
- The pig (Sus scrofa) TRB locus consists
of 38 TRBV genes belonging to 24 TRBV subgroups, 3 TRBD genes
belonging to 3 TRBD sets, 20 TRBJ genes belonging to 3 TRBJ sets, and
3 TRBC genes.
- The TRBV genes span 364
kilobases (kb), the TRBD genes span 6584 bases
(b), the TRBJ genes span 9186 bases (b) and
the TRBC genes span 20 kilobases (kb).
Clusters
- The TRBV genes are localized in 2 V-CLUSTER:
- the 5' V-CLUSTER, classically in 5' of the TRBD, TRBJ and
TRBC, includes 37 TRBV genes belonging to 23 subgroups (26 genes
are functional and 11 genes are pseudogenes).
- the 3' V-CLUSTER, downstream of the TRBC in inverted
orientation, includes 1 TRBV gene (functional).
- The TRBD, TRBJ and TRBC genes are localized in three
D-J-C-CLUSTER between the 5' V-CLUSTER and the 3' V-CLUSTER:
- the first D-J-C-CLUSTER, in 3' of the 5' V-CLUSTER,
includes 1 TRBD gene (functional), 7 TRBJ genes (6 genes are
functional and 1 gene is pseudogene) and 1 TRBC
gene (functional). The C-proximal TRBJ gene, TRBJ1-7,
being localized at 2.953 kilobases in 5' of TRBC1.
- the second D-J-C-CLUSTER, in 5' of the 3' V-CLUSTER,
includes 1 TRBD gene (functional), 7 TRBJ genes (6 genes are
functional and 1 gene is pseudogene) and 1 TRBC gene (functional).
The C-proximal TRBJ gene, TRBJ3-7, being localized at 1.650
kilobases in 5' of TRBC3.
- the third D-J-C-CLUSTER, in 5' of the 3' V-CLUSTER,
includes 1 TRBD gene (functional), 6 TRBJ genes (6 genes are
functional) and 1 TRBC gene (functional).
The most C-proximal TRBJ gene, TRBJ2-6, being localized at 2.647
kilobases in 5' of TRBC2.
Bornes of the pig (Sus scrofa) TRB locus
- MOXD2 (5' borne) has been identified 3.5 kb upstream of
TRBV1, the most 5' gene in the locus.
- EPHB6 (3' borne) has been identified 49 kb downstream of
TRBV30, the most 3' gene in the locus.
- Created:
- 18/02/2019
- Last updated:
- Wednesday, 12-Jun-2024 16:02:37 CEST
- Author:
- Imène Chentli
