Rhesus monkey (Macaca mulatta) TRB locus on chromosome 3
- The Rhesus monkey (Macaca mulatta) TRB locus is on
chromosome 3. The orientation of the locus is forward (FWD).
- The Rhesus monkey (Macaca mulatta) TRB locus spans 736 kilobases (kb),
from 10 kb upstream of the most 5' gene in the locus, TRBV1-1 (P), to 10 kb
downstream of the most 3' gene in the locus, TRBV30 (F).
The Locus representation
encompasses 800 kb including the 5' borne MOXD2 and the 3' borne EPHB6.
- The Rhesus monkey (Macaca mulatta) TRB locus consists
of 77 TRBV genes belonging to 32 TRBV subgroups, 2 TRBD genes belonging to 2 TRBD set, 14 TRBJ genes belonging to 2 TRBJ set and
and 2 TRBC genes.
- The TRBV genes span 642
kilobases (kb), the TRBD genes span 12 kilobases
(kb), the TRBJ genes span 7233 bases (b) and
the TRBC genes span 12 kilobases (kb).
Clusters
- The TRBV genes are localized in 2 V-CLUSTER:
- the 5' V-CLUSTER, classically in 5' of the TRBD, TRBJ and
TRBC, includes 76 TRBV genes belonging to 31 subgroups (50-53 genes
are functional, 6-7 genes are ORF and 16-20 genes are pseudogenes).
- the 3' V-CLUSTER, downstream of the TRBC in inverted
orientation, includes 1 TRBV gene (functional).
- The TRBD, TRBJ and TRBC genes are localized in two
D-J-C-CLUSTER between the 5' V-CLUSTER and the 3' V-CLUSTER:
- the first D-J-C-CLUSTER, in 3' of the 5' V-CLUSTER,
includes 1 TRBD gene (functional), 6 TRBJ genes (functional) and 1 TRBC
gene (functional). The most C-proximal TRBJ gene, TRBJ1-6,
being localized at 2.660 kilobases in 5' of TRBC1.
- the second D-J-C-CLUSTER, in 5' of the 3' V-CLUSTER,
includes 1 TRBD gene (functional), 8 TRBJ genes (7 genes are
functional and 1 gene is ORF) and 1 TRBC gene (pseudogene).
The most C-proximal TRBJ gene, TRBJ2-7, being localized at 3.578
kilobases in 5' of TRBC2.
Bornes of the Rhesus monkey (Macaca mulatta) TRB locus
- MOXD2 (5' borne) has been identified 75 kb upstream of
TRBV1-1, the most 5' gene in the locus.
- EPHB6 (3' borne) has been identified 48 kb downstream of
TRBV30, the most 3' gene in the locus.
- Created:
- 05/10/2018
- Last updated:
- Friday, 22-Sep-2023 18:22:19 CEST
- Author:
- Morgane Bertignac
