IMGT Repertoire (IG and TR)

Western lowland gorilla (Gorilla gorilla gorilla) TRD locus on chromosome 14

The Western lowland gorilla (Gorilla gorilla gorilla) TRD locus is on chromosome 14. The orientation of the locus is reverse (REV).
The Western lowland gorilla (Gorilla gorilla gorilla) TRA/TRD locus spans 959 kilobases (kb), from 10 kb upstream of the most 5' gene in the locus, TRAV1-1 (F), to 10 kb downstream of the most 3' gene in the locus, TRAC (F). The Locus representation encompasses 1000 kb including the 5' borne OR10G3 and the 3' borne DAD1.
The Western lowland gorilla (Gorilla gorilla gorilla) TRD locus consists of 3 TRDV genes belonging to 3 TRDV subgroups, 3 TRDD genes, 4 TRDJ genes and a unique TRDC gene.
The TRDV genes span 38 kilobases (kb), the TRDJ genes span 11 kilobases (kb), the TRDD genes span 19 kilobases (kb), the TRDC gene spans 6 kilobases (kb).

The TRDV genes are localized in 2 V-CLUSTER:
- the 5' V-CLUSTER, classically in 5' of the TRDD, TRDJ and TRDC, includes 2 TRDV genes belonging to 2 subgroups.
- the 3' V-CLUSTER, downstream of the TRDC in inverted orientation, includes 1 TRDV gene.
The TRDD, TRDJ and TRDC genes are localized in one D-J-C-CLUSTER between the 5' V-CLUSTER and the 3' V-CLUSTER:
- The CLUSTER includes 3 TRDD, 4 TRDJ and 1 TRDC functional .

OR10G3 (5' borne) has been identified 43 kb upstream of TRAV1-1, the most 5' gene in the locus.
DAD1 (3' borne) has been identified 13 kb downstream of TRAC, the most 3' gene in the locus.