IMGT Repertoire (IG and TR)

Potential germline repertoire: domestic ferret (Mustela putorius furo) TRBV, TRBD and TRBJ genes

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Domestic ferret (Mustela putorius furo) TRBV genes

The domestic ferret (Mustela putorius furo) TRB locus comprises 34 TRBV genes belonging to 28 TRBV subgroups:

• 19-20 FUNCTIONAL
• 3 ORF (Open Reading Frame)
• 11-12 PSEUDOGENE

The TRBV genes are localized in 2 V-CLUSTER:

• the 5' V-CLUSTER, classically in 5' of the TRBD, TRBJ and TRBC, includes 33 TRBV genes belonging to 27 subgroups (19/20 genes are functional, 3 genes are ORF and 10/11 genes are pseudogenes)
• the 3' V-CLUSTER, downstream of the TRBC in inverted orientation, includes 1 TRBV gene (pseudogene)

Localization of the V-CLUSTER in the locus	IMGT subgroup	Functional	ORF	Pseudogene	Total
5' V-CLUSTER	TRBV1	0	1	0	1
	TRBV2	0	0	1 (0:1)	1
	TRBV3	1	0	0	1
	TRBV4	2	0	0	2
	TRBV5	2	0	2 (0:2)	4
	TRBV6	0	1	0	1
	TRBV7	1(+1)*	0	(+1(0:1))*	2
	TRBV8	1	0	0	1
	TRBV10	0	0	1 (0:1)	1
	TRBV11	0	0	1 (0:1)	1
	TRBV12	2	0	0	2
	TRBV15	1	0	0	1
	TRBV16	1	0	0	1
	TRBV17	0	0	1 (0:1)	1
	TRBV18	1	0	0	1
	TRBV19	1	0	0	1
	TRBV20	0	1	0	1
	TRBV21	1	0	0	1
	TRBV22	1	0	0	1
	TRBV23	0	0	1 (0:1)	1
	TRBV24	0	0	1 (1:0)	1
	TRBV25	1	0	0	1
	TRBV26	1	0	0	1
	TRBV27	1	0	0	1
	TRBV28	0	0	1 (1:0)	1
	TRBV29	1	0	0	1
	TRBVA	0	0	1 (0:1)	1
3' V-CLUSTER	TRBV30	0	0	1 (1:0)	1
Total		19(+1)*	3	11(+1)*	34

In the column 'Pseudogene', the number of pseudogenes with V-REGION in-frame and the number of pseudogenes with frameshift(s) are shown separated by two dots, between parentheses.
* An asterisk indicates that the following genes have alleles with different functionalities:
TRBV7-1 gene : FUNCTIONAL or PSEUDOGENE out-of-frame.

Domestic ferret (Mustela putorius furo) TRBD genes

The domestic ferret (Mustela putorius furo) TRB locus comprises 2 TRBD genes belonging to 2 TRBD set:

• 2 FUNCTIONAL

IMGT group	IMGT set or subgroup (if any)	Functional	ORF	Pseudogene	Total
TRBD	TRBD1	1	0	0	1
	TRBD2	1	0	0	1
Total		2	0	0	2

Domestic ferret (Mustela putorius furo) TRBJ genes

The domestic ferret (Mustela putorius furo) TRB locus comprises 12 TRBJ genes belonging to 2 TRBJ set:

• 8 FUNCTIONAL
• 3 ORF (Open Reading Frame)
• 1 PSEUDOGENE

IMGT group	IMGT set or subgroup (if any)	Functional	ORF	Pseudogene	Total
TRBJ	TRBJ1	3	2	1	6
	TRBJ2	5	1	0	6
Total		8	3	1	12

More information:
Gene table: domestic ferret (Mustela putorius furo) TRBV
Gene table: domestic ferret (Mustela putorius furo) TRBD
Gene table: domestic ferret (Mustela putorius furo) TRBJ
Locus description: domestic ferret (Mustela putorius furo) TRB

Created: 21/09/2018
Last updated: Friday, 23-Aug-2024 21:00:10 CEST
Author: Perrine Pégorier
Editor: Chantal Ginestoux, Ifigeneia Sideri

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