Domestic ferret (Mustela putorius furo) TRB locus
- The domestic ferret (Mustela putorius furo) TRB locus spans 339 kilobases (kb),
from the borne (MOXD2) upstream of the most 5' gene in the locus, TRBV1 (ORF), to 10 kb
downstream of the most 3' gene in the locus, TRBV30 (P).
The Locus representation
encompasses 380 kb including the 5' borne MOXD2 and the 3' borne EPHB6.
- The domestic ferret (Mustela putorius furo) TRB locus consists
of 34 TRBV genes belonging to 27 TRBV subgroups and 1 TRBV clan, 2 TRBD genes
belonging to 2 TRBD set, 12 TRBJ genes belonging to 2 TRBJ set, and
2 TRBC genes.
- The TRBV genes span 298
kilobases (kb), the TRBD genes span 6.85 kilobases
(kb), the TRBJ genes span 6.565 kilobases (kb) and
the TRBC genes span 15 kilobases (kb).
Clusters
- The TRBV genes are localized in 2 V-CLUSTER:
- the 5' V-CLUSTER, classically in 5' of the TRBD, TRBJ and
TRBC, includes 33 TRBV genes belonging to 27 subgroups (19/20 genes
are functional, 3 genes are ORF and 10/11 genes are pseudogenes).
- the 3' V-CLUSTER, downstream of the TRBC in inverted
orientation, includes 1 TRBV gene (pseudogene).
- The TRBD, TRBJ and TRBC genes are localized in two
D-J-C-CLUSTER between the 5' V-CLUSTER and the 3' V-CLUSTER:
- the first D-J-C-CLUSTER, in 3' of the 5' V-CLUSTER,
includes 1 TRBD gene (functional), 6 TRBJ genes (3 genes are
functional, 2 genes are ORF and 1 gene is pseudogene) and 1 TRBC
gene (functional). The most C-proximal TRBJ gene, TRBJ1-6,
being localized at 2.405 kilobases in 5' of TRBC1.
- the second D-J-C-CLUSTER, in 5' of the 3' V-CLUSTER,
includes 1 TRBD gene (functional), 6 TRBJ genes (5 genes are
functional and 1 gene are ORF) and 1 TRBC gene (functional).
The most C-proximal TRBJ gene, TRBJ2-6, being localized at 3.256
kilobases in 5' of TRBC2.
Bornes of the domestic ferret (Mustela putorius furo) TRB locus
- MOXD2 (5' borne) has been identified 5 kb upstream of
TRBV1, the most 5' gene in the locus.
- EPHB6 (3' borne) has been identified 33 kb downstream of
TRBV30, the most 3' gene in the locus.
- Created:
- 21/09/2018
- Last updated:
- Friday, 23-Aug-2024 21:00:10 CEST
- Author:
- Perrine Pégorier
- Editor:
- Ifigeneia Sideri
