Print of this table: Pallarès, N. et al., Exp. Clin. Immunogenet., 16, 36-60 (1999). PMID:10087405 UPDATE: Human IGHV (10/2002)

Since October 2012, new IGHV alleles are not reported in this table. For the polymorphism description, you can refer to the following Alignments of alleles.

• Fct: FUNCTIONALITY
• F: Functional
• P: Pseudogene
• ORF: Open Reading Frame
• vg: Vestigial

The IMGT allele table refers to the V-REGION polymorphism. It does not include polymorphisms in the other parts of the V-GENE. V-REGION alleles are only described for genes which have at least one Functional or ORF allele. The accession number of a reference sequence is given for each allele.

Click on a gene name to get the alignment of the corresponding V-REGION alleles.
Click on an accession number to get the sequence and additional information (IMGT annotations, IMGT flat file, Coding regions...).

Because of STOP-CODON (in frame) at position 39, but the gene has been found rearranged. For that reason the IGHV4-55 gene has been added to IMGT/V-QUEST (May 2005).

IGHV subgroup	IGHV gene name	Fct	IGHV allele name	Accession number	confirmed by genetics and/or data	Description of mutations
1	IGHV1-2	F	IGHV1-2*01	X07448	+	c44  ,P15  |c163  ,R55  |a223  ,R75  |g233  ,t234  ,S78  |t299  ,V100  |
		F	IGHV1-2*02	X62106	+	|c163>t,R55>W|            |g233>t,t234>g,S78>M|t299>c,V100>A|
		F	IGHV1-2*03	X92208		c44>t,P15>L|c163>t,R55>W|            |g233>t,t234>g,S78>M|t299>c,V100>A|
		F	IGHV1-2*04	Z12310		|c163>t,R55>W|a223>t,R75>W|g233>t,t234>g,S78>M|t299>c,V100>A|
		F	IGHV1-2*05	HM855674	+	|g233>t,t234>g,S78>M|
	IGHV1-3	F	IGHV1-3*01	X62109	+	c6  |t12  |t167  ,I56  |a208  ,K70  |a291  |c296  ,T99  |
		F	IGHV1-3*02	X62107		c6>t|t12>g|t167>g,I56>S|a208>g,K70>E|a291>g|c296>t,T99>M|
	IGHV1-8	F	IGHV1-8*01	M99637	+
		F	IGHV1-8*02	HM855457		t108>c|
	IGHV1-18	F	IGHV1-18*01	M99641	+	g282  |
		F	IGHV1-18*02	X60503		g282>a|
		F	IGHV1-18*03	HM855463		c296>t,T99>M|
	IGHV1-24	F	IGHV1-24*01	M99642	+
	IGHV1-45	F	IGHV1-45*01	X92209		g139  ,G47  |t237  |
		F	IGHV1-45*02	AB019438		|t237>c|
		F	IGHV1-45*03	Z17391		g139>a,G47>R|t237>c|
	IGHV1-46	F	IGHV1-46*01	X92343	+	c92  ,T31  |g315  |
		F	IGHV1-46*02	J00240		c92>a,T31>N|
		F	IGHV1-46*03	L06612		|g315>t|
	IGHV1-58	F	IGHV1-58*01	M29809	+	g115  ,V39  |
		F	IGHV1-58*02	AB019438		g115>a,V39>M|
	IGHV1-69	F	IGHV1-69*01	L22582	+	g6  |g18  |g54  |g100  ,A34  |g163  ,G55  |t178  ,F60  |c185  ,T62  |g238  ,A80  |g244  ,E82  |g291  ,E97  |
		F	IGHV1-69*02	Z27506	+	g6>c|g18>a|     |g100>a,A34>T|g163>a,G55>R|t178>c,F60>L|c185>t,T62>I|            |g244>a,E82>K|
		F	IGHV1-69*03	X92340		|g291>t,E97>D|
		F	IGHV1-69*04	M83132	+	g6>c|                        |g163>a,G55>R|t178>c,F60>L|c185>t,T62>I|            |g244>a,E82>K|
		F	IGHV1-69*05	X67905		g6>c|                                                               |g238>a,A80>T|
		F	IGHV1-69*06	L22583	+	|g244>a,E82>K|
		F	IGHV1-69*07	Z29978		|g163>a,G55>R|
		F	IGHV1-69*08	Z14309		g6>c|g18>a|     |g100>a,A34>T|g163>a,G55>R|t178>C,F60>L|                         |g244>a,E82>K|
		F	IGHV1-69*09	Z14307		|g163>a,G55>R|t178>c,F60>L|c185>t,T62>I|            |g244>a,E82>K|
		F	IGHV1-69*10	Z14300		g6>c|     |g54>a|                         |t178>c,F60>L|c185>t,T62>I|            |g244>a,E82>K|
		F	IGHV1-69*11	Z14296	+	g6>c|                        |g163>a,G55>R|t178>c,F60>L|
		F	IGHV1-69*12	Z14301	+	g6>c
		(F)	IGHV1-69*13	Z14214(st)	+	g6>c|     |g54>a|
	IGHV1-c	ORF	IGHV1-c*01	HM855760
	IGHV1-f	F	IGHV1-f*01	Z12305		c201  |
		F	IGHV1-f*02	Z29977		c201>t|
2	IGHV2-5	F	IGHV2-5*01	X62111		a4  ,I2  |a31  ,T11  |g39  |g60  |g103  ,V35  |g106  ,G36  |g118  ,G40  |a175  ,N59  |a202  ,S68  |c234  |c299  ,A100  |c314  ,A105  |a317  ,c318  ,H106  |
		F	IGHV2-5*02	Z14072	+	|a175>g,N59>D|
		F	IGHV2-5*03	X93619		|a175>g,N59>D|            |c234>t|
		F	IGHV2-5*04	L21963		|c299>g,A100>G|c314>t,A105>V|a317>g,c318>g,H106>R|
		F	IGHV2-5*05	L21964		|a175>g,N59>D|a202>g,S68>G|
		F	IGHV2-5*06	L21966		|g39>a|                                            |a175>g,N59>D|a202>g,S68>G|
		F	IGHV2-5*07	L21968		|c299>g,A100>G|c314>t,A105>V|
		F	IGHV2-5*08	L21971		a4>g,I2>V|a31>g,T11>A|     |g60>a|g103>a,V35>M|g106>c,G36>R|g118>a,G40>S|a175>g,N59>D|
		F	IGHV2-5*09	L21972		a4>g,I2>V|                                                              |a175>g,N59>D|a202>g,S68>G|
		F	IGHV2-5*10	X69690		|a175>g,N59>D|                                               |a317>g,c318>g,H106>R|
	IGHV2-26	F	IGHV2-26*01	M99648	+
	IGHV2-70	F	IGHV2-70*01	L21969	+	a2  ,Q1  |g4  ,V2  |g14  ,R5  |g31  ,A11  |a60  |t67  ,C23  |a70  ,T24  |t106  ,C36  |t116  ,V39  |a138  |c157  ,L53  |t164  ,L55  |a197  ,Y66  |t210  |g216  ,K72  |a297  |c299  ,A100  |a301  ,c302  ,T101  |g303  |c309  |c314  ,A105  |g317  ,g318  ,R106  |t320  ,I107  |
		F	IGHV2-70*02	X92241	+	|a297>g|             |a301>g,c302>t,T101>V|
		F	IGHV2-70*03	X92238	+	|g14>a,R5>K|                                         |t106>c,C36>R|                                |t164>g,L55>R|a197>t,Y66>F|                   |a297>g|             |a301>g,c302>t,T101>V|
		F	IGHV2-70*04	Z12330		|g14>a,R5>K|                                         |t106>c,C36>R|                                |t164>g,L55>R|a197>t,Y66>F|
		F	IGHV2-70*05	Z27502		|t106>c,C36>R|t116>c,V39>A|                   |t164>g,L55>R|a197>t,Y66>F|
		F	IGHV2-70*06	X92239		|g14>a,R5>K|                                         |t106>c,C36>R|                                |t164>g,L55>R|a197>t,Y66>F|t210>c|            |a297>g|             |a301>g,c302>t,T101>V|
		F	IGHV2-70*07	X92243		|a138>g|                                                          |a297>g|             |a301>g,c302>t,T101>V|
		F	IGHV2-70*08	X92245		|a70>g,T24>A|                                             |t164>g,L55>R|                                |a297>g|             |a301>g,c302>t,T101>V|
		F	IGHV2-70*09	L21962		|g4>a,V2>I|g14>a,R5>K|g31>a,A11>T|a60>g|t67>c,C23>R|                                                                                          |g216>c,K72>N|      |c299>g,A100>G|                    |g303>a|      |c314>t,A105>V|
		F	IGHV2-70*10	L21965		|g14>a,R5>K|                                         |t106>c,C36>R|                   |c157>a,L53>I|t164>g,L55>R|
		F	IGHV2-70*11	L21967		a2>g,Q1>R|                                                                                                            |t164>g,L55>R|
		F	IGHV2-70*12	L21970		|g4>a,V2>I|g14>a,R5>K|g31>a,A11>T|a60>g|                                                                                                                                                             |g303>a|                     |g317a,g318>c,R106>H|t320>g,I107>R|
		F	IGHV2-70*13	AB019437		|c309>t|
3	IGHV3-7	F	IGHV3-7*01	M99649	+	g144  |
		F	IGHV3-7*02	X92288		g144>a|
		F	IGHV3-7*03	HM855666		t300>c|
	IGHV3-9	F	IGHV3-9*01	M99651	+
		F	IGHV3-9*02	HM855577		t88>c, F30>S|
	IGH3-11	F	IGHV3-11*01	M99652	+	|g13  ,V5  |g32     ,G11     |g47     ,G16     |g178  ,G60  |a184  ,c185  ,T62  |t188  ,I63  |t196  ,Y66  |a206     ,D69     |g240  |c243  ,D81  |c296     ,g297     ,T99     |g301  ,g303  ,V101  |t304  ,a305  ,Y102  |t307  ,a308  ,c309  ,Y103  |t312  |c314  ,A105  |
		P	IGHV3-11*02	M15496		9^10>ins^t|          |g32>del#,G11>del#|g47>del#,G16>del#|                                                          |a206>del#,D69>del#|      |c243>g,D81>E|c296>del#,g297>del#,T99>del#|g301>t,g303>a,V101>L|t304>c,a305>t,Y102>L|t307>a,a308>c,c309>t,Y103>T|t312>c|c314>a,A105>E|
		F	IGHV3-11*03	X92287		|g13>t,V5>L|                                   |g178>a,G60>S|a184>t,c185>a,T62>Y|t188>c,I63>T|t196>a,Y66>N|                  |g240>a|
		F	IGHV3-11*04	HM855329	+	c300>t|
		F	IGHV3-11*05	HM855583	+	g178>a, G60>S|
	IGHV3-13	F	IGHV3-13*01	X92217	+	g9  ,Q3  |t52  ,S18  |g77  ,S26  |g95  ,S32  |t165  |t167  ,I56  |c222  |g224  ,R75  |
		F	IGHV3-13*02	M99653		g9>t,Q3>H|t52>g,S18>A|           |g95>a,S32>N|t165>c|t167>a,I56>N|c222>g|
		F	IGHV3-13*03	U29582		|c77>g,S26>C|                                      |g224>a,R75>Q|
		F	IGHV3-13*04	HM855616		|g153>a|
	IGHV3-15	F	IGHV3-15*01	X92216	+	g23  ,g24  ,G8  |g32  ,G11  |a40  ,K14  |a81  |t89  ,F30  |g119  ,S40  |t159  |c163  ,R55  |a169  ,K57  |a178  ,T60  |g181  ,D61  |g196  ,D66  |c210  |a242  ,D81  |a275  ,N92  |c279  |a297  |a320  |
		F	IGHV3-15*02	M99654		|g32>c,G11>A|
		F	IGHV3-15*03	M99408	+	g23>c,g24>c,G8>A|g32>c,G11>A|a40>c,K14>Q|     |t89>g,F30>C|                                             |a178>g,T60>A|g181>a,D61>N|            |c210>t|a242>t,D81>V|
		F	IGHV3-15*04	M99402		|a169>g,K57>E|
		F	IGHV3-15*05	M99403		|c279>t|
		F	IGHV3-15*06	M99404		|t159>c|                                                   |g196>a,D66>N|
		F	IGHV3-15*07	M99406		|a81>t|           |g119>a,S40>N|t159>c|
		F	IGHV3-15*08	M99400		g23>c      ,G8>A|           |a40>c,K14>Q|     |t89>g,F30>C|                   |c163>t,R55>C|            |a178>g,T60>A|g181>a,D61>N|            |c210>t|            |a275>t,N92>I|      |a297>g|a320>g|
	IGHV3-16	ORF	IGHV3-16*01	M99655		a6  |a9  |
		ORF	IGHV3-16*02	AB019440		a6>g|a9>g|
	IGHV3-19	P	IGHV3-19*01	M99656	+
	IGHV3-20	F	IGHV3-20*01	M99657	+	t68  ,C23  |
	IGHV3-21	F	IGHV3-21*01	AB019439	+	g9  |
		F	IGHV3-21*02	M99658		g9>a|
		F	IGHV3-21*03	HM855323		g297>a|
		F	IGHV3-21*04	HM855688		t300>c|
	IGHV3-23	F	IGHV3-23*01	M99660	+	c164  ,A55  |a169  ,g170  ,S57  |g172  ,t174  ,G58  |a175  ,S59  |g181  ,G61  |c201  |c203  ,A68  |c237  |c243  |
		F	IGHV3-23*02	M35415	+	|c203>g,A68>G|c237>a|
		F	IGHV3-23*03	AM940223		c164>t,A55>V|a169>t,g170>a,S57>Y|g172>a,t174>c,G58>S|a175>g,S59>G|g181>a,G61>S|c201>t|                   |c243>t|
		F	IGHV3-23*04	AJ879486	+	t13>g|
		F	IGHV3-23*05	AY757302	+	a154>t, g155>a, S>Y|g157>a, t159>a, G>S|g166>a, G>S|
	IGHV3-30	F	IGHV3-30*01	M83134	+	g18  ,E6  |a27  |a49  ,R17  |c75  |g80  ,G27  |c101  ,t102  ,A34  |t135  |a138  |a150  |g163  ,V55  |t169  ,c170  ,a171  ,S57  |c201  |g202  ,A68  |a229  ,T77  |c257  ,T86  |g267  |a275  ,N92  |t288  |a293  ,D98  |g317  ,R106  |
		F	IGHV3-30*02	L26401	+	|a49>g,R17>G|c75>g|           |c101>g,t102>c,A34>G|             |a150>g|g163>t,V55>F|t169>c,c170>g,a171>g,S57>R|c201>t|                                                                              |g317>a,R106>K|
		F	IGHV3-30*03	M99663		|c101>g,t102>c,A34>G|             |a150>g|                                       |c201>t|
		F	IGHV3-30*04	L06615	+	|a150>g|
		F	IGHV3-30*05	M77323		|c101>g,t102>c,A34>G|                                                                                                                                     |a293>g,D98>G|
		F	IGHV3-30*06	L06617	+	|c75>g|           |c101>c,t102>c,A34>G|
		F	IGHV3-30*07	L06614	+	|t288>c|
		F	IGHV3-30*08	M62737		g18>c,E6>D|                       |g80>c,G27>A|
		F	IGHV3-30*09	M77300		|a150>g|                                                           |a229>g,T77>A|
		F	IGHV3-30*10	M77326		|g202>a,A68>T|
		F	IGHV3-30*11	M77331		|c75>g|
		F	IGHV3-30*12	M77338		|a27>g|           |c75>g|           |c101>g,t102>c,A34>G|                                                                                                                              |t288>c|
		F	IGHV3-30*13	M77339		|c101>g,t102>c,A34>G|                                                                                             |c257>g,T86>R|
		F	IGHV3-30*14	M77324		|a150>g|                                                                                     |g267>t|
		F	IGHV3-30*15	M77327		|a275>g,N92>S|
		F	IGHV3-30*16	M77328		|t135>c|
		F	IGHV3-30*17	M77329		|a138>g|
		F	IGHV3-30*18	X92214	+	|c101>g,t102>g,A34>G|             |a150>g|                                       |c201>t|                                                                              |g317>a,R106>K|
		F	IGHV3-30*19	L06616	+	|c75>g|           |c101>g,t102>g,A34>G|             |a150>g|
	IGHV3-30-3	F	IGHV3-30-3*01	X92283	+	c75  |g317  ,R106  |
		F	IGHV3-30-3*02	M77302		c75>g|g317>a,R106>K|
	IGHV3-33	F	IGHV3-33*01	AB019439	+	g6  |g150  |g170  ,g171  ,W57  |t177  |t212  ,V71  |t246  |a251  ,K84  |a263  ,Y88  |g317  ,R106  |
		F	IGHV3-33*02	M99665		g6>a|                                 |t212>c,V71>A|      |a251>c,K84>T|a263>t,Y88>F|
		F	IGHV3-33*03	M77305		|t246>c|                         |g317>a,R106>K|
		F	IGHV3-33*04	M77335		|g150>a|                   |t177>c|
		F	IGHV3-33*05	M77334		|g170>c,g171>a,W57>S|
		F	IGHV3-33*06	HM855436		|g317>a, R106>K|
	IGHV3-35	ORF	IGHV3-35*01	M99666	+
	IGHV3-38	ORF	IGHV3-38*01	M99669		c302  ,A101  |
ORF		IGHV3-38*02	AB019439		c302>t,A101>V|
IGHV3-43	F	IGHV3-43*01	M99672	+	t32  ,V11  |a100  ,T34  |g138  |t172  ,W58  |
	F	IGHV3-43*02	HM855392		t32>g,V11>G|a100>g,T34>A|g138>a|t172>g,W58>G|
IGHV3-47	P	IGHV3-47*01	Z18900		c58  |c101  ,A34  |t149  ,L50  |t267     ,L89     |t270  ,H90  |t310  |
	P	IGHV3-47*02	AB019438		c58>a|c101>t,A34>V|t149>c,L50>P|                  |t270>a,H90>Q|
	P	IGHV3-47*03	M99674		c58>a|c101>t,A34>V|t149>c,L50>P|t267>del#,L89>del#|t270>a,H90>Q|t310>g|
IGHV3-48	F	IGHV3-48*01	M99675	+	g48  |c96  |a100  ,g101  ,c102  ,S34  |a178  ,S60  |t246  |c287  ,A96  |g303  |
	F	IGHV3-48*02	AB019438		|c287>a,A96>D|
	F	IGHV3-48*03	U03893	+	g48>a|c96>t|a100>g,g101>a,c102>a,S34>E|a178>g,S60>G|t246>c|            |g303>t|
	F	IGHV3-48*04	HM855336		|t246>c|
IGHV3-49	F	IGHV3-49*01	M99676		g50  ,R17  |t93  |g94  ,D32  |g100  ,A34  |t124  ,F42  |a202  ,T68  |g245  ,G82  |
	F	IGHV3-49*02	M99401		g50>c,R17>P|t93>g|g94>t,D32>Y|g100>c,A34>P|t124>g,F42>V|a202>g,T68>A|g245>a,G82>D|
	F	IGHV3-49*03	AB019438		|a202>g,T68>A|g245>a,G82>D|
	F	IGHV3-49*04	AM940220		|t124>g ,F42>V|a202>g,T68>A|g245>a,G82>D|
	F	IGHV3-49*05	AM940221		|a202>g,T68>A|g245>a,G82>D|
IGHV3-53	F	IGHV3-53*01	M99679		t19  ,S7  |g133  ,A45  |c210  |g315  |a318  |
	F	IGHV3-53*02	Z12342		t19>a,S7>T|
	F	IGHV3-53*03	J03617		|g133>c,A45>P|c210>t|g315>t|a318>g|
	F	IGHV3-53*04	HM855453		|a37>,I13>V|       |g241>c, D81>H|
IGHV3-64	F	IGHV3-64*01	M99682	+	g1  ,E1  |g26  ,G9  |g70  ,A24  |t198  |t201  |a205  ,N69  |t210  |c265  ,t267  ,L89  |g274  ,g275  ,G92  |c279  |t296  ,M99  |c314  ,A105  |g317  ,R106  |
	F	IGHV3-64*02	AB019437		|g26>a,G9>E|                         |a205>g,N69>D|
	F	IGHV3-64*03	M77298		|g70>t,A24>S|t198>c|t201>c|a205>g,N69>D|t210>a|c265>g,t267>c,L89>V|g274>a       ,G92>S|c279>t|t296>c,M99>T|c314>t,A105>V|g317>a,R106>K|
	F	IGHV3-64*04	M77299		g1>c,E1>Q|          |g70>t,A24>S|t198>c|t201>c|a205>g,N69>D|t210>a|      ,t267>g,     |g274>a,g275>a,G92>N|      |t296>c,M99>T|
	F	IGHV3-64*05	M77301		|g70>t,A24>S|t198>c|t201>c|a205>g,N69>D|t210>a|c265>g,      ,L89>V|g274>a       ,G92>S|c279>t|t296>c,M99>T|c314>t,A105>V|g317>a,R106>K|
IGHV3-66	F	IGHV3-66*01	X92218		g24  |g37  ,V13  |a81  |g175  ,G59  |a223  |c288  |g319  |
	F	IGHV3-66*02	Z27504		|a223>c|c288>t|
	F	IGHV3-66*03	AB019437	+	g24>a|g37>a,V13>I|a81>g|g175>t,G59>C|a223>c|c288>t|
	F	IGHV3-66*04	X70208	+	|g319>c|
IGHV3-72	F	IGHV3-72*01	X92206	+	t186  |
	F	IGHV3-72*02	Z29979		t186>c|
IGHV3-73	F	IGHV3-73*01	X70197	+	t21  |
	F	IGHV3-73*02	AB019437		t21>c|
IGHV3-74	F	IGHV3-74*01	L33851	+	c21  |g197  ,c198  ,S66  |
	F	IGHV3-74*02	Z17392		c21>t|
	F	IGHV3-74*03	J00239		|g197>c,c198>g,S66>T|
IGHV3-d	F	IGHV3-d*01	Z18898
IGHV3-h	P(1)	IGHV3-h*01	AJ879484	+
	P(1)	IGHV3-h*02	AJ879485	+	|g303>t|
IGHV3-NL1	F	IGHV3-NL1*01	HM855939
4	IGHV4-4	F	IGHV4-4*01	X05713	+	c20  ,S7  |c46  ,P16  |g50  ,G17  |g70  ,A24  |g73  ,V25  |c93  |a97  ,g98  ,t99  ,S33  |a100  ,N34  |t120  |g124  ,V42  |c129  |c136  ,a138  ,P46  |g147  |g163  ,a164  ,a165  ,E55  |c172  ,a173  ,t174  ,H58  |g207  |a234  ,I78  |a245  ,K82  |g308  ,C103  |
		F	IGHV4-4*02	X92232	+	|c46>t,P16>S|                                                                                                                                                                                                                           |g308>a,C103>Y|
		F	IGHV4-4*03	X92252	+	|g308>a,C103>Y|
		F	IGHV4-4*04	X92253	+	|g73>a,V25>I|                                                                                                                                                                                       |g308>a,C103>Y|
		F	IGHV4-4*05	X92254		c20>t,S7>L|                                                                                                                                                                                                                                       |g308>a,C103>Y|
		F	IGHV4-4*06	Z75355		|a234>g,I78>M|a245>c,K82>T|g308>a,C103>Y|
		F	IGHV4-4*07	X62112		|c46>t,P16>S|g50>a,G17>E|g70>a,A24>T|           |c93>t|a97>t,g98>a,t99>c,S33>Y|a100>t,N34>Y|t120>c|g124>a,V42>I|c129>g|c136>g,a138>c,P46>A|g147>a|g163>c,a164>g,a165>t,E55>R|c172>a,a173>c,t174>c,H58>T|g207>c|a234>g,I78>M|a245>c,K82>T|g308>a,C103>Y|                                               |a234>g,I78>M|a245>c,K82>T|g308>a,C103>Y|
	IGHV4-28	F	IGHV4-28*01	X05714	+	g6  |g48  |g49  ,c51  ,D17  |c185  ,T62  |g297  |c299  ,A100  |a319  |
		F	IGHV4-28*02	M83133	+	g48>a|g49>c,c51>g,D17>Q|c185>t,T62>I|
		F	IGHV4-28*03	X92233		|a319>g|
		F	IGHV4-28*04	X56358		|g297>c|c299>g,A100>G|
		F	IGHV4-28*05	HM855339		|c194>t, T65>I|
		F	IGHV4-28*06	HM855782		|t196>a, Y66>N|
	IGHV4-30-2	F	IGHV4-30-2*01	L10089	+	t163  ,a164  ,c165  ,Y55  |c172  ,H58  |a237  |g245  ,R82  |c288  |g291  |c300  |c315  |g319  |
		F	IGHV4-30-2*02	M95122		|c288>t|             |c315>g|
		F	IGHV4-30-2*03	X92229		t163>a,a164>g,c165>t,Y55>S|c172>t,H58>Y|a237>c|g245>c,R82>T|c288>t|g291>a|c300>t|c315>g|g319>c|
		F	IGHV4-30-2*04	Z75351		|g245>c,R82>T|      |g291>a|         |c315>g|
		F	IGHV4-30-2*05	HM855593		|c228>t|                                   |g245>c,R82>T|   |c285>t|      |g291>a|
	IGHV4-30-4	F	IGHV4-30-4*01	Z14238	+	g18  ,E6  |a48  |c49  ,g51  ,Q17  |c134  ,P45  |a166  ,I56  |t228  |c288  |a291  |
		F	IGHV4-30-4*02	Z14239		|a48>g|c49>g,g51>c,Q17>D|                                |c288>a|
		F	IGHV4-30-4*03	X92274		|a291>g|
		F	IGHV4-30-4*04	X92275		g18>c,E6>D|                                    |a166>t,I56>F|
		F	IGHV4-30-4*05	Z75353		|t228>c|
		F	IGHV4-30-4*06	Z75360		|c134>a,P45>H|
	IGHV4-31	F	IGHV4-31*01	L10098		a8  ,Q3  |g37  ,V13  |c69  |c84  |g100  ,G34  |a164  ,Y55  |t224  ,L75  |a237  |a244  ,c245  ,T82  |t249  |t285  |t285-c287          |a295  ,T99  |t304  ,Y102  |
		F	IGHV4-31*02	M99683	+	|c69>t|                               |t224>g,L75>R|
		F	IGHV4-31*03	Z14237	+	|t224>g,L75>R|
		F	IGHV4-31*04	M95120		a8>g,Q3>R|                                                 |t224>g,L75>R|
		F	IGHV4-31*05	M95121		|t224>g,L75>R|                                        |t285-c287>del(3nt)#|a295>g,T99>A|
		F	IGHV4-31*06	X92270		|g100>a,G34>S|            |t224>g,L75>R|
		F	IGHV4-31*07	X92271		|c84>a|                         |t224>g,L75>R|
		F	IGHV4-31*08	X92272		|t224>g,L75>R|a237>c|                   |t249>c|
		F	IGHV4-31*09	X92273		|t224>g,L75>R|      |      ,c245>a,T82>K|t249>c|t285>c|
		F	IGHV4-31*10	Z14235		|g37>t,V13>L|                        |a164>g,Y55>C|t224>g,L75>R|      |a244>c,      ,T82>P|t249>c|                                       |t304>g,Y102>D|
	IGHV4-34	F	IGHV4-34*01	AB019439	+	a12  |g15  |c16  ,Q6  |g20  ,W7  |g25  ,A9  |t37  ,L13  |g48  |g49  ,E17  |t85  ,S29  |t88  ,F30  |a118  ,S40  |c129  |c137  ,P46  |g147  |g163  ,a165  ,E55  |a169  ,a170  ,t171  ,N57  |c172  ,H58  |a180  |t199  ,Y67  |g207  |g226  ,t227  ,c228  ,V76  |a234  ,I78  |c249  |c263  ,S88  |g270  ,K90  |a274  ,S92  |c285  |t300  |a308  ,Y103  |
		F	IGHV4-34*02	M99684		|g15>a|
		F	IGHV4-34*03	X92255	+	|t300>c|
		F	IGHV4-34*04	X92236		|t199>a,Y67>N|      |      ,t227>c       ,V76>A|
		F	IGHV4-34*05	X92237		|a118>t,S40>C|      |c137>t,P46>L|                                                                         |t199>a,Y67>N|      |      ,t227>c       ,V76>A|
		F	IGHV4-34*06	X92256		|a274>g,S92>G|      |t300>c|
		F	IGHV4-34*07	X92258		|             ,t171>c      |                                                                                                                                    |t300>c|
		F	IGHV4-34*08	M95113		|t85>a,S29>T|
		F	IGHV4-34*09	Z14241		a12>g|     |c16>g,Q6>E|g20>c,W7>S|g25>c,A9>P|t37>g,L13>V|g48>a|g49>c,E17>Q|                                                        |g147>a|                                                                                      |              c228>t      |            |c249>t|                                      |c285>t|t300>c|
		F	IGHV4-34*10	Z14242		a12>g|     |c16>g,Q6>E|g20>c,W7>S|g25>c,A9>P|t37>g,L13>V|                                                                          |g147>a|                                                                                      |g226>a,             ,V76>I|a234>g,I78>M|      |c263>a,S88>Y|                                |t300>c|
		F	IGHV4-34*11	X05716		|t88>g,F30>V|            |c129>g|                   |g163>t,a165>t,E55>Y|a169>t              ,N57>Y|c172>t,H58>Y|a180>g|t199>a,Y67>N|g207>c|       t227>c       ,V76>A|                                |g270>c,K90>N|                   |t300>c|a308>g,Y103>C|
		F	IGHV4-34*12	X56591		|      a170>t        ,N57>I|
		F	IGHV4-34*13	Z75356		|g207>c|
	IGHV4-39	F	IGHV4-39*01	AB019439	+	a2  ,Q1  |t56  ,L19  |c237  |g258  ,Q86  |t262  ,S88  |a291  |t300  |c319  |
		F	IGHV4-39*02	X05715		|g258>c,Q86>H|                          |c319>g|
		F	IGHV4-39*03	X92259		|t300>c|
		F	IGHV4-39*04	X92297		|a291>g|
		F	IGHV4-39*05	M95116		|t56>c,L19>P|
		F	IGHV4-39*06	Z14236		a2>g,Q1>R|           |c237>a|            |t262>c,S88>P|a291>g|t300>c|
		F	IGHV4-39*07	AM940222		|c237>a|                         |a291>g|t300>c|   c319>g
	IGHV4-55	P	IGHV4-55*01	M99685	+	c44  ,P15  |c237  |a251  ,K84  |c255  ,N85  |a263  ,Y88  |c288  |c290  ,A97  |g291  |t319  |
		P	IGHV4-55*02	X92223		|c237>a|
		P	IGHV4-55*03	X92263		|c237>a|                         |a263>c,Y88>S|
		P	IGHV4-55*04	X92265		c44>t,P15>L|c237>a|
		P	IGHV4-55*05	X92266		c44>t,P15>L|
		P	IGHV4-55*06	X92267		|c255>g,N85>K|            |c288>t|
		P	IGHV4-55*07	X92268		|a251>g,K84>R|            |a263>c,Y88>S|                   |g291>a|
		P	IGHV4-55*08	X92234		|c237>a|                                                                 |t319>g|
		P	IGHV4-55*09	X92235		|a263>c,Y88>S|      |c290>t,A97>V|      |t319>a|
	IGHV4-59	F	IGHV4-59*01	AB019438	+	g12  |g16  ,E6  |c20  ,S7  |c25  ,P9  |g37  |g51  ,E17  |a70  ,T24  |t76  ,c77  ,S26  |a88  ,I30  |c135  |c136  ,a138  ,P46  |a147  |t163  ,a164  ,t165  ,Y55  |t172  ,a173  ,c174  ,Y58  |a196  ,N66  |c207  |c228  |a234  ,I78  |a237  |c249  |g258  |c285  |t288  |g291  |c300  |g319  |a320  |
F		IGHV4-59*02	M29812		|a88>g,I30>V|
F		IGHV4-59*03	M95114		|g258>a|
F		IGHV4-59*04	M95117		|             ,c174>t      |a196>t,N66>Y|c207>g|      |a234>g,I78>M|                           |t288>c|g291>a|c300>t|
F		IGHV4-59*05	M95118		|c135>g|      ,a138>g      |      |t163>c,a164>g,      ,Y55>R|             ,c174>t      |a196>t,N66>Y|c207>g|                   |a237>c|                    |t288>c|g291>a|c300>t|
F		IGHV4-59*06	M95119		|t76>a      ,S26>T|                  |c136>g,a138>t,P46>A|a147>c|             ,t165>c,     |                          |a196>t,N66>Y|c207>g|c228>t|                   |c249>t|      |c285>t|t288>c|
F		IGHV4-59*07	X56360		|g51>c,E17>D|
F		IGHV4-59*08	HM855471		|t288>c|g291>a|g319>c|
F		IGHV4-59*09	Z75359		|a320>g|
F		IGHV4-59*10	Z14243		g12>a|g16>c,E6>Q|c20>g,S7>W|c25>g,P9>A|g37>t|           |a70>g,T24>A|     ,c77>a,S26>Y|                  |c136>g,a138>c,P46>A|a147>g|t163>c,a164>g,      ,Y55>R|t172>a,a173>c,       Y58>T|                          |a234>g,I78>M|                           |t288>c|             |g319>t|
IGHV4-61	F	IGHV4-61*01	M29811	+	g4  ,V2  |g48  |g49  ,E17  |g88  ,V30  |g97  ,G33  |a100  ,S34  |a118  ,S40  |c136  ,a138  ,P46  |g162  |t163  ,a164  ,Y55  |t172  ,a173  ,Y58  |c245  ,T82  |g258  ,Q86  |t288  |g289-g291         |g291  |g315  |g319  |
	F	IGHV4-61*02	L10097		|g48>a|g49>c,E17>Q|g88>a,V30>I|                                     |c136>g,a138>c,P46>A|      |t163>c,a164>g,Y55>R|t172>a,a173>c,Y58>T|                         |t288>c|                  |g291>a|
	F	IGHV4-61*03	X92230		|g258>c,Q86>H|
	F	IGHV4-61*04	X92250		|g162>a|                                                                        |g289-g291>del(3nt)|
	F	IGHV4-61*05	X56356		g4>c,V2>L|                 |g88>a,V30>I|g97>a,G33>S|            |a118>g,S40>G|                                                                  |c245>a,T82>K|            |t288>c|
	ORF	IGHV4-61*06	Z75347		|t288>c|                         |g315>c|
	F	IGHV4-61*07	Z75348		|g319>c|
	F	IGHV4-61*08	AB019437		|a100>g,S34>G|
IGHV4-b	F	IGHV4-b*01	Z12367	+	g70  ,A24  |
	F	IGHV4-b*02	X56365		g70>a,A24>T|
5	IGHV5-51	F	IGHV5-51*01	M99686	+	c45  |t116  ,I39  |g139  ,G47  |c148  |t247>c,S83  |
		F	IGHV5-51*02	M18806		|t116>c,I39>T|            |c148>t|
		F	IGHV5-51*03	X56368	+	c45>g|
		F	IGHV5-51*04	X56367		c45>g|                                |t247>c,S83>P|
		F	IGHV5-51*05	Z27449		|g139>a,G47>R|
	IGHV5-a	F	IGHV5-a*01	X92227		t21  |c148  |c225  ,H75  |c288     ,A96     |
		F(2)	IGHV5-a*02	X92279		|c148>t|            |c288>del#,A96>del#|
		F	IGHV5-a*03	X56375		t21>c|
		F	IGHV5-a*04	X56376		|c225>g,H75>Q|
6	IGHV6-1	F	IGHV6-1*01	J04097	+	a27  |
		F	IGHV6-1*02	Z14223		a27>g|
7	IGHV7-4-1	F	IGHV7-4-1*01	L10057	+	t274  ,C92  |g278  ,c279  ,S93  |
		F	IGHV7-4-1*02	X62110		t274>a,C92>S|
		F	IGHV7-4-1*03	X92290		t274>a,C92>S|g278>c,c279>g,S93>T|
		F	IGHV7-4-1*04	HM855485		|c257>t,T86>M| |t274>a,c92>S|
		F	IGHV7-4-1*05	HM855361		|c257>t,T86>M| |t274>a,c92>S| |a305>g,Y102>C|
	IGHV7-81	ORF	IGHV7-81*01	AB019437	+

(st):sterile transcript.

IMGT notes:

(1)	Missing translation initiation codon, (atg) is replaced by (aag).
(2)	The absence of nt in codon 96 in the sequence X92279 (c288>del compared with X92227) is a sequencing error because of an expressed cDNA (U00543) has been described. Therefore, the functionality of IGHV5-a*02 has been changed from pseudogene (P) to functional (F).

Created: 07/08/1997
Last updated: Wednesday, 12-Jun-2024 16:02:41 CEST
Authors: Joumana Jabado Michaloud, Nathalie Pallarès and Dominique Scaviner
Editor: Chantal Ginestoux

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