The orientation of the human (Homo sapiens) TRB locus on the chromosome 7 (7q34) is forward (FWD).
Legend:
Colors are according to IMGT color menu for genes.
The boxes representing the genes are not to scale. Exons are not shown.
A double slash // indicates a gap in genome assembly. Distances in bp (base pair) or in kb (kilobase) associated with a double slash are taken
into account in the length of the lines and included in the numbers displayed at the right end of the lines.
A dotted line ... indicates the distance in kb (kilobase) between the locus and its bornes (5' borne and the most 5' gene in the locus and/or 3'
borne and the most 3' gene in the locus) on the top and bottom lines, respectively. These distances are not represented at scale and/or are not
included in IMGT-LOCUS-UNIT and may not be included in the numbers displayed at the right ends of these two lines
.
TRBV gene designations according to Rowen et al. (1996). Nomenclature adopted by IMGT.
Single arrows show genes whose polarity is opposite to that of the
D-J-C-CLUSTER.
Double arrows indicate insertion/deletion polymorphisms.
• PRSS58 (serine protease 58, trypsinogen-like TRYX3, TRY1) (5' borne) has been identified 41 kb upstream of TRBV1 (P), the most 5' gene in the locus.
• EPHB6 (EPH receptor B6) (3' borne) has been identified 41 kb downstream of TRBV30 (F), the most 3' gene in the locus.
T3 to T8 indicate trypsinogen or trypsinogen-like genes. T3 (PRSS3P3, TRY3) is at 7.4 kb upstream of TRBV1. T4 to T8 are localized between TRBV29-1 and TRBD1.
Gene localization is according to data from
IMGT/LocusView.
This locus representation with only the functional genes is used with IMGT/GeneFrequency.
* When needed, indicate the presence of allele(s) with another functionality: see above human (Homo sapiens) TRB locus