IMGT Repertoire (IG and TR)

In cattle (bovine, Bos taurus) and sheep (ovine, Ovis aries), the TRG genes are organized in two loci on chromosome 4:

the TRG1 locus at position 4q3.1 (102.8 cM) spans about 150kb and comprises three TRGC genes (TRGC5, TRGC3 and TRGC4), each TRGC gene is preceded by one or several V genes and J genes [1].
the TRG2 locus at position 4q2.2 (69.4 cM) spans about 90kb in sheep and comprises three TRGC genes (TRGC1, TRGC2 and TRGC6), each one preceded by its own set of V and J genes. [2].

The TRG1 locus at 4q3.1 is syntenic to the human TRG locus at 7p14, whereas the TRG2 locus at 4q2.2 is a peculiarity of the cattle and sheep.

Sheep (Ovis aries) TRG locus on chromosome 4 (4q3.1 and 4q2.1)

Locus representation sheep TRG

Legend:
Colors are according to IMGT color menu for genes.
The boxes representing the genes are not to scale. Exons are not shown.
A double slash // indicates a gap in genome assembly. Distances in bp (base pair) or in kb (kilobase) associated with a double slash are taken into account in the length of the lines and included in the numbers displayed at the right end of the lines.
A dotted line ... indicates the distance in kb (kilobase) between the locus and its bornes (5' borne and the most 5' gene in the locus and/or 3' borne and the most 3' gene in the locus) on the top and bottom lines, respectively. These distances are not represented at scale and/or are not included in IMGT-LOCUS-UNIT and may not be included in the numbers displayed at the right ends of these two lines .

Arrows indicate the TRGC cassettes and the transcriptional orientation of their genes.

Locus representation with only the functional genes: Sheep (Ovis aries) TRG

Locus representation sheep TRG

* When needed, indicate the presence of allele(s) with another functionality: see above Sheep (Ovis aries) TRG locus

IMGT references:

[1] Vaccarelli, G. et al., Gene, 357, 103-114 (2005). PMID:16125878
[2] Miccoli, M. C. et al., J. Mol. Evol., 57, 52-62 (2003). PMID:12962306
[3] Vaccarelli, G. et al., BMC Genomics., 9:81 (2008). PMID:18282289

See also:

Created:: 19/10/2006
Last updated:: 22/09/2023
Authors:: Yan Wu and Marie-Paule Lefranc