Here you are: IMGT Web resources > IMGT Repertoire (IG and TR) > 1. Locus and genes
Citing this page:Bosc, N. and Lefranc, M.-P., Exp. Clin. Immunogenet., 17, 216-228 (2000) PMID: 11096260 pdf

"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

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TRBV genes are designated by a number for the subgroup followed, whenever there are several genes belonging to the same subgroup, by a dash and a number for their relative localisation in the locus at 6A-C. Numbers increase from 5' to 3' in the locus.

IMGT subgroup IMGT gene name IMGT allele name Fct Chromosomal localization R T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Strain Clone names Accession numbers Positions in the sequence Secondary accession numbers Strain Clone names Accession numbers Positions in the sequence
TRBV1 TRBV1 TRBV1*01 F 6 (20.5 cM) + + + BALB/c V2S1 AE000663 [22]
TRBV1*02 (F) 6 (20.5 cM) + + + BALB/c X01642 [19] #c
TRBV2 TRBV2 TRBV2*01 F 6 (20.5 cM) + + + BALB/c V4S1 AE000663 [22]
TRBV3 TRBV3 TRBV3*01 F 6 (20.5 cM) + + + BALB/c V16S1 AE000663 [22]
TRBV3*02 (F) 6 (20.5 cM) + + + B10.A (19) VbetaB10 MAP X03865 [9] #c
TRBV4 TRBV4 TRBV4*01 F 6 (20.5 cM) + + + C57BL/6 Vbeta10 MAP X56725 [11] (1) BALB/c V10S1 AE000663 [22]
TRBV4*02 (F) 6 (20.5 cM) + + + SWR/J Vbeta10 MAP AJ249819 [25] #c
TRBV5 TRBV5 TRBV5*01 F 6 (20.5 cM) + + + BALB/c V1S1 AE000663 [22]
TRBV5*02 (F) 6 (20.5 cM) + + + BALB/c X00438 [10] #c
TRBV5*03 (F) 6 (20.5 cM) + + + AKR Vbeta1 MAP X02779 [1] #c
TRBV5*04 (F) 6 (20.5 cM) + + + B10.S(9R) (19) Vbeta1 MAP M20878 [17] #c
TRBV5*05 (F) 6 (20.5 cM) + + + SWR/J Vbeta1 MAP AJ249820 [25] #c
TRBV6 TRBV6 TRBV6*01 P (2) 6 (20.5 cM) BALB/c V26S1P AE000663 [22]
TRBV7 TRBV7 TRBV7*01 P (3) 6 (20.5 cM) BALB/c V27S1P AE000663 [22]
TRBV8 TRBV8 TRBV8*01 P (4) 6 (20.5 cM) BALB/c V28S1P AE000663 [22]
TRBV9 TRBV9 TRBV9*01 P (5) 6 (20.5 cM) BALB/c VbetaN8 X16693 [15] (6) BALB/c V24S1P AE000663 [22]
TRBV10 TRBV10 TRBV10*01 P (7) 6 (20.5 cM) BALB/c VbetaN9 X16694 [15] (6) BALB/c V25S1P AE000663 [22]
TRBV11 TRBV11 TRBV11*01 P (8) 6 (20.5 cM) BALB/c V29S1P AE000663 [22]
TRBV12 TRBV12-1 TRBV12-1*01 F 6 (20.5 cM) C57BL/6 Vbeta5.2 MAP M15614 [7] BALB/c V5S2 AE000663 [22]
TRBV12-1*02 (F) 6 (20.5 cM) + + + NZW Vbeta5.2 MAP M30881 [3] #c
TRBV12-2 TRBV12-2*01 F 6 (20.5 cM) C57BL/6 Vbeta5.1 MAP M15613 [7] BALB/c V5S1 AE000663 [22]
TRBV12-2*02 (F) 6 (20.5 cM) + + + BALB/c Vbeta5.1 MAP X02782 [1] #c
TRBV12-3 TRBV12-3*01 P (9) 6 (20.5 cM) C57BL/6 Vbeta5.3 MAP M15615 [7] BALB/c V5S3P AE000663 [22]
TRBV13 TRBV13-1 TRBV13-1*01 F 6 (20.5 cM) C57BL/6 Vbeta8.3 MAP M15618 [7]
TRBV13-1*02 F 6 (20.5 cM) + + + BALB/c V8S3 AE000663 [22]
TRBV13-2 TRBV13-2*01 F 6 (20.5 cM) C57BL/6 Vbeta8.2 MAP M15617 [7] BALB/c V8S2 AE000663 [22]
TRBV13-2*02 (F) 6 (20.5 cM) + + + BALB/c nu/nu Vbeta8.2 MAP M27350 [14] (10) #c
TRBV13-2*03 (F) 6 (20.5 cM) + + + CBA/J Vbeta8.2 MAP M26417 [12] #c
TRBV13-2*04 (F) 6 (20.5 cM) + + + CI27 (20) Vbeta8.2 AJ249823 [20] (11) #c
TRBV13-2*05 (F) 6 (20.5 cM) + + + ER34 (20) Vbeta8.2 AJ250103 [20] (11) #c
TRBV13-3 TRBV13-3*01 F 6 (20.5 cM) C57BL/6 Vbeta8.1 MAP M15616 [7] BALB/c V8S1 AE000664 [22]
TRBV14 TRBV14 TRBV14*01 F 6 (20.5 cM) + + + BALB/c V13S1 AE000664 [22]
TRBV15 TRBV15 TRBV15*01 F 6 (20.5 cM) BALB/c V12S1 AE000664 [22]
TRBV16 TRBV16 TRBV16*01 F 6 (20.5 cM) + + + C57BL/6 L29434 [8] BALB/c V11S1 AE000664 [22]
TRBV16*02 (F) 6 (20.5 cM) + + + C57BL/6 Vbeta5 MAP M13670 [2] #c
TRBV16*03 (F) 6 (20.5 cM) + + + C57BL/6 M15459 [21] #c
TRBV16*04 (F) 6 (20.5 cM) + + + C57BL/6 Vbeta11 X14388 [18] #c
TRBV17 TRBV17 TRBV17*01 F 6 (20.5 cM) + + + BALB/c V9S1 AE000664 [22]
TRBV18 TRBV18 TRBV18*01 P (12) 6 (20.5 cM) BALB/c VbetaN5 X16692 [15] BALB/c V23S1P AE000664 [22]
TRBV19 TRBV19 TRBV19*01 F 6 (20.5 cM) + + + BALB/c V6S1 AE000664 [22]
TRBV19*02 (F) 6 (20.5 cM) + + + C57BL/6 X01643 [19] #c
TRBV19*03 (F) 6 (20.5 cM) + + + SWR/J Vbeta6 MAP AJ249821 [25] #c
TRBV20 TRBV20 TRBV20*01 F 6 (20.5 cM) + + + BALB/c V15S1 AE000664 [22]
TRBV20*02 (F) 6 (20.5 cM) + + + SJL Vbeta15 MAP M11859 [4] #c
TRBV21 TRBV21 TRBV21*01 ORF (13) 6 (20.5 cM) BALB/c Vbeta19 X16691 [15] (14) BALB/c V19S1P AE000664 [22]
TRBV22 TRBV22 TRBV22*01 P (15) 6 (20.5 cM) BALB/c Vbeta3.3P X16690 [15] (14) BALB/c V22S1P AE000664 [22]
TRBV23 TRBV23 TRBV23*01 F 6 (20.5 cM) BALB/c V20S1 AE000664 [22] BALB/c Vbeta20 X59150 [24] °
TRBV24 TRBV24 TRBV24*01 F 6 (20.5 cM) PWK Vbeta17a2 M61184 [5]
TRBV24*02 P (16) 6 (20.5 cM) BALB/c V17S1 AE000664 [22]
TRBV24*03 (ORF) (17) 6 (20.5 cM) + BALB/c Vbeta17a1 MAP M16203 [13] #g
TRBV24*04 (F) 6 (20.5 cM) + Czech II VB17a L48997 [26] #g
TRBV25 TRBV25 TRBV25*01 P (12) 6 (20.5 cM) BALB/c VbetaN1 X16689 [15] BALB/c V21S1P AE000664 [22]
TRBV26 TRBV26 TRBV26*01 F 6 (20.5 cM) + + + B10.A K02548 [6] BALB/c V3S1 AE000664 [22]
TRBV26*02 (F) 6 (20.5 cM) + + + SWR/J Vbeta3 MAP AJ249822 [25] #c
TRBV27 TRBV27 TRBV27*01 P (8) 6 (20.5 cM) BALB/c V30S1P AE000664 [22]
TRBV28 TRBV28 TRBV28*01 P (8) 6 (20.5 cM) BALB/c V31S1P AE000664 [22]
TRBV29 TRBV29 TRBV29*01 F 6 (20.5 cM) + + + BALB/c V7S1 AE000664 [22]
TRBV29*02 (F) 6 (20.5 cM) + + + BALB/c X00696 [23] #c
TRBV30 TRBV30 TRBV30*01 F 6 (20.5 cM) + + + BALB/c Vbeta18 X16695 [15] (14) BALB/c V18S1 AE000664 [22]
TRBV31 TRBV31 TRBV31*01 F 6 (20.5 cM) + + + BALB/c Vbeta14 MAP X03277 [16] BALB/c V14S1 AE000665 [22] (18)
TRBV31*02 (F) 6 (20.5 cM) + + + B10.A Vbeta14 MAP M26418 [12] #c

#c: rearranged cDNA.
#g: rearranged genomic DNA.
°: DNA genomic sequence, but not known as being germline or rearranged.
MAP: Mapped reference sequences.

IMGT notes:
  1. (1) The last codon of the CDR3-IMGT of of the germline V-REGION is a STOP-CODON which may disappear during rearrangements.
  2. (2) No L-PART1, frameshift in V-REGION .
  3. (3) STOP-CODON in L-PART1, GAT replaced by GGT in DONOR-SPLICE, frameshift in V-EXON.
  4. (4) STOP-CODON in FR2-IMGT.
  5. (5) No L-PART1, STOP-CODON in V-REGION.
  6. (6) V-EXON is partial: no L-PART2.
  7. (7) No L-PART1, no 1st-CYS, no 2nd-CYS.
  8. (8) Frameshift in V-EXON.
  9. (9) INSERTION of 2 bp in position 290 to 291 leading to a frameshift in FR1-IMGT, STOP-CODON in FR3-IMGT.
  10. (10) V-REGION is partial: AA 1 to 3 are absent (partial FR1-IMGT).
  11. (11) V-REGION is partial: AA 1 and 2 are absent (partial FR1-IMGT).
  12. (12) STOP-CODON in V-REGION, frameshift in V-REGION.
  13. (13) Unexpected position of DONOR_SPLICE.
  14. (14) V-GENE is partial: no L-PART1, no L-PART2.
  15. (15) STOP-CODON in FR1-IMGT and FR3-IMGT, DELETION of 1 pb in codon 58 leading to a frameshift in CDR2-IMGT.
  16. (16) STOP-CODON in FR3-IMGT.
  17. (17) Unexpected position of ACCEPTOR-SPLICE.
  18. (18) In the TRB locus the TRBV14 gene is localised 3' from the TRBC2 gene and is in an inverted orientation of transcription.
  19. (19) B10.A and B10.S[9R] are congenics strains, B10 is the abbreviated symbol of C57BL/10.
  20. (20) CI27 and ER34 are wild mice.
IMGT references:
  1. [1] Barth R.K. et al., Nature, 316, 517-523 (1985). PMID:2412120
  2. [2] Behlke M.A. et al., Science, 229, 566-570 (1985). PMID:3875151
  3. [3] Behlke M.A. et al., Nature, 322, 379-382 (1986). PMID:3488509
  4. [4] Behlke M.A. et al., Proc. Natl. Acad. Sci. USA., 83, 767-771 (1986). PMID:3456168
  5. [5] Cazenave P.A. et al., Cell, 63, 717-728 (1990). PMID:2225073
  6. [6] Chien Y.H. et al., Nature, 309, 322-326 (1984). PMID:6328306
  7. [7] Chou H.S. et al., Proc. Natl. Acad. Sci. USA., 84, 1992-1996 (1987). PMID:3470773
  8. [8] Epplen J.T. et al., Proc. Natl. Acad. Sci. USA., 83, 4441-4445 (1986). PMID:3487087
  9. [9] Fink P.J. et al., Nature, 321, 219-226 (1986). PMID:3012351
  10. [10] Hedrick S.M. et al., Nature, 308, 153-158 (1984). PMID:6546606
  11. [11] Hirama T. et al., Eur. J. Immunol., 21, 483-488 (1991). PMID:1705514
  12. [12] Johnson N.A. et al., J. Immunol., 142, 3298-3304 (1989). PMID:2468715
  13. [13] Kappler J.W. et al., Cell, 49, 263-271 (1987). PMID:3471350
  14. [14] Kishihara K. et al., Eur. J. Immunol., 17, 477-482 (1987). PMID:2883009
  15. [15] Louie M.C. et al., J. Exp. Med., 170, 1987-1998 (1989). PMID:2531193
  16. [16] Malissen M. et al., Nature, 319, 28-33 (1986). PMID:3484541
  17. [17] McElligott D.L. et al., J. Immunol., 140, 4123-4131 (1988). PMID:2453567
  18. [18] Palmer M.S. et al., Nucleic. Acid. Res., 17, 2353 (1989). PMID:2784852
  19. [19] Patten P. et al., Nature, 312, 40-46 (1984). PMID:6092964
  20. [20] Pullen A.M. et al., J. Exp. Med., 171, 49-62 (1990). PMID:2295881
  21. [21] Rinaldy A. et al., Immunogenetics, 21, 403-406 (1985). PMID:3873411
  22. [22] Rowen L. et al., Unpublished (1997).
  23. [23] Saito H. et al., Nature, 309, 757-762 (1984). PMID:6330561
  24. [24] Six A. et al., J. Exp. Med., 174, 1263-1266 (1991). PMID:1834762
  25. [25] Smith L.R. et al., J. Immunol., 144, 3234-3237 (1990). PMID:2139080
  26. [26] Tomonari K. et al., Unpublished (1996).
Created:
26/10/1999
Last updated:
08/01/2013
Authors:
Nathalie Bosc