Here you are: IMGT Web resources > IMGT Repertoire (IG and TR) > 1. Locus and genes
Citing this page:Ruiz, M. et al., Exp. Clin. Immunogenet., 16, 173-184 (1999) PMID: 10087405 pdf UPDATE: Human IGHV (10/2002, 12/2009)

"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

Click on:

Truncated pseudogenes not assigned to subgroups with functional genes

Pseudogenes which could not be assigned to subgroups with functional genes are designated by a roman number between parentheses, corresponding to the clans [2], followed by a dash and a number for the localization from 3' to 5' in the locus. All these pseudogenes have truncations [2].

IMGT gene name IMGT allele name Fct Chromosomal localization R T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Clone names Accession numbers Positions in the sequence (V-REGION/V-EXON) Secondary accession numbers Clone names Accession numbers Positions in the sequence (V-REGION/V-EXON)
IGHV(II)-1-1 IGHV(II)-1-1*01 P (9) 14q32.33 - - - 60001-80000 (1) 4-1.1P MAP AB019441 [2] 78294-78475 (2) ABC13_11_000049738900_M6 reverse-complement-of-AC279151 IMGT000054 [6] 9857..10038 (7)
ABC13_11_000049738900_M6 AC279151 [6] complement(29542..29723) (7)
IGHV(II)-15-1 IGHV(II)-15-1*01 P 14q32.33 - - - 68001-70000 (1) 4-15.1P MAP AB019440 [2] 69050-69320 (2)
IGHV(II)-20-1 - P 14q32.33 - - - 4-20.1P MAP AC245166 205128..205432 (4) 173650_ABC10_2_1_000044515200_G6 MK540646 [5]
1204935_ABC13_11_000048707500_J20 MK540651 [5]
IGHV(II)-22-1 IGHV(II)-22-1*01 P 14q32.33 - - - 169001-170000 (1) 4-22.1P MAP AB019439 [2] 169320-169588 (2) CH17-60O17 AC245166 [3] 154629-154897
ABC14-954514B22 AC244492 37909-38177
IGHV(II)-22-1*02 P 14q32.33 ABC9-43993300H10 AC206018 9241..9509 ABC9-43849600N9 AC244473 complement(4297-4565)
IGHV(II)-22-1D IGHV(II)-22-1D*01 P 14q32.33 - - - ABC14-954514B22 AC244492 [3] 27068-27336 (2)
IGHV(II)-26-2 IGHV(II)-26-2*01 P 14q32.33 - - - 117001-120000 (1) CH17-60O17 MAP AC245166 [3] 103308-103609 ABC11-47355000A14 KC162924 [3] complement(1-262)
ABC11-48019600E23 AC244464 [3] 24768-25069
4-26.2P AB019439 [2] 118318-118630 (2)
ABC12_000049044400_N18 AC279998 [7] complement(10992..11293) (7)
ABC12_000049057200_J24 AC280062 [7] 9853..10154 (7)
IGHV(II)-28-1 IGHV(II)-28-1*01 P 14q32.33 - - - 103001-105000 (1) 4-28.1P MAP AB019439 [2] 103603-103855 (2)
IGHV(II)-28-1*02 P 14q32.33 - - - ABC11-47355000A14 MAP KC162924 [3] complement(14736-14988) ABC11-48019600E23 AC244464 [3] 10037-10290
IGHV(II)-28-1*03 P 14q32.33 - - - CH17-60O17 AC245166 [3] 88543-88825
IGHV(II)-28-1*04 P 14q32.33 - - - ABC12_000049044400_N18 AC279998 [7] complement(25784..26066)
IGHV(II)-30-1 IGHV(II)-30-1*01 P 14q32.33 - - - 90001-95000 (1) 4-30.1P MAP AB019439 [2] 90666-90939 (2) ABC11-47355000A14 KC162924 [3] complement(27966-28266)
ABC11-47150400I4 AC231260 [3] complement(11818-12118)
IGHV(II)-30-1*02 P 14q32.33 - - - CH17-60O17 AC245166 [3] 75277-75577
IGHV(II)-30-21 IGHV(II)-30-21*01 P 14q32.33 - - - CH17-60O17 MAP AC245166 [3] 63511-63809 ABC8-718240A7 AC244411 [3] complement(4719-5017)
ABC11-47150400I4 AC231260 [3] complement(23586-23884)
ABC11-47355000A14 KC162924 [3] complement(39734-40032)
IGHV(II)-30-32 IGHV(II)-30-32*01 P 14q32.33 - - - ABC11-47354200D2 MAP AC244456 [3] complement(9723-10023) ABC8-718240A7 AC244411 [3] complement(16873-17173)
ABC11-47150400I4 AC231260 [3] complement(35740-36040)
IGHV(II)-30-41 IGHV(II)-30-41*01 P 14q32.33 - - - ABC11-47354200D2 MAP AC244456 [3] complement(21059-21357) ABC11-49598600E10 KC162925 [3] complement(1-125)
ABC8-718240A7 AC244411 [3] complement(28634-28932)
IGHV(II)-30-51 IGHV(II)-30-51*01 P 14q32.33 - - - ABC11-47354200D2 MAP AC244456 [3] complement(34304-34604) ABC11-49598600E10 KC162925 [3] complement(13072-13372)
ABC24-366M9 AC245243 [3] complement(10890-11190)
IGHV(II)-31-1 IGHV(II)-31-1*01 P 14q32.33 - - - 78001-82000 (1) 4-31.1P MAP AB019439 [2] 78924-79232 (2) ABC11-49598600E10 KC162925 [3] complement(24840-25138)
IGHV(II)-33-1 IGHV(II)-33-1*01 P 14q32.33 - - - 65001-70000 (1) CH17-60O17 MAP AC245166 [3] 50566-50866 ABC11-49598600E10 KC162925 [3] complement(37783-38083)
4-33.1P AB019439 [2] 65947-66220 (2)
ABC9_3_5_000046182700_E23 reverse-complement-of-AC279153 IMGT000056 [6] 28941..29241 (7)
ABC9_3_5_000046182700_E23 AC279153 [6] complement(12140..12440) (7)
IGHV(II)-33-1*02 P 14q32.33 - - - ABC12_000049044400_N18 MAP AC279998 [7] complement(38707..39007)
IGHV(II)-40-1 IGHV(II)-40-1*01 P 14q32.33 - - - 191001-200000 (1) 4-40.1P MAP AB019438 [2] 192620-192696 (2)
IGHV(II)-43-1 IGHV(II)-43-1*01 P 14q32.33 - - - 158001-161000 (1) 4-43.1P MAP AB019438 [2] 160618-160826 (2)
IGHV(II)-43-1*02 P 14q32.33 - - - 158001-161000 (1) CM000676.2 MAP IMGT000035 406845..407054 (7)
IGHV(II)-43-1D IGHV(II)-43-1D*01 P 14q32.33 - - - ABC10-44145400L1 MAP AC233755 [3] 23722-23931
IGHV(II)-43-1D*02 P (5) 14q32.33 - - - ABC7-611322I15 MAP AC242184 [4] complement(30234..30443) (7)
IGHV(II)-44-2 IGHV(II)-44-2*01 P 14q32.33 - - - 135001-140000 (1) 4-44.2P MAP AB019438 [2] 136146-139382 (2) 174779_ABC12_000049207600_G9 MK540650 [5] 19258-19494 (7)
IGHV(II)-46-1 IGHV(II)-46-1*01 P 14q32.33 - - - 116001-120000 (1) 4-46.1P MAP AB019438 [2] 117614-117771 (2) ABC12_000049057200_G6 reverse-complement-of-AC279154 IMGT000057 [6] 24372..24518 (7)
ABC12_000049057200_G6 AC279154 [6] complement(15837..15983) (7)
IGHV(II)-49-1 IGHV(II)-49-1*01 P 14q32.33 - - - 68001-70000 (1) 4-49.1P MAP AB019438 [2] 68955-69225 (2) ABC11_2_1_000048324700_C2 reverse-complement-of-AC279152 IMGT000055 [6] 39517..39816 (7)
ABC11_2_1_000048324700_C2 AC279152 [6] complement(670..969) (7)
IGHV(II)-51-2 IGHV(II)-51-2*01 P 14q32.33 - - - 48001-49000 (1) 4-51.2P MAP AB019438 [2] 48581-48843 (2) ABC11_2_1_000048324700_C2 reverse-complement-of-AC279152 IMGT000055 [6] 19146..19435 (7)
ABC11_2_1_000048324700_C2 AC279152 [6] complement(21051..21340) (7)
IGHV(II)-53-1 IGHV(II)-53-1*01 P 14q32.33 - - - 33001-35000 (1) 4-53.1P MAP AB019438 [2] 33605-33874 (2) ABC11_2_1_000048324700_C2 reverse-complement-of-AC279152 IMGT000055 [6] 4169..4468 (7)
ABC11_2_1_000048324700_C2 AC279152 [6] complement(36018..36317) (7)
IGHV(II)-53-1*02 P 14q32.33 - - - 33001-35000 (1) CM000676.2 MAP IMGT000035 (100) 279891-280190
IGHV(II)-60-1 IGHV(II)-60-1*01 P 14q32.33 - - - 195001-200000 (1) 4-60.1P MAP AB019437 [2] 195563-195831 (2) ABC9_3_2_000043845600_J7 reverse-complement-of-AC279155 IMGT000058 [6] 23212..23480 (7)
ABC9_3_2_000043845600_J7 AC279155 [6] complement(14471..14739) (7)
IGHV(II)-60-1*02 P (9) 14q32.33 - - - 171417_ABC10_2_1_000044455000_O21 MAP MK540647 [5] 20278-20546 (7)
IGHV(II)-62-1 IGHV(II)-62-1*01 P 14q32.33 - - - 182001-188500 (1) 4-62.1P MAP AB019437 [2] 182749-183021 (2)
IGHV(II)-62-1*02 P 14q32.33 - - - 182001-188500 (1) CM000676.2 MAP IMGT000035 <229057-229329 (7)(100) ABC9_3_2_000043845600_J7 reverse-complement-of-AC279155 IMGT000058 [6] 10039..10708
ABC9_3_2_000043845600_J7 AC279155 [6] complement(27243..27912)
IGHV(II)-62-1*03 P (9) 14q32.33 - - - 171417_ABC10_2_1_000044455000_O21 MAP MK540647 [5] 7087-7756 (7)
IGHV(II)-65-1 IGHV(II)-65-1*01 P 14q32.33 - - - 160001-165000 (1) 4-65.1P MAP AB019437 [2] 161481-161753 (2)
IGHV(II)-67-1 IGHV(II)-67-1*01 P 14q32.33 - - - 146001-150000 (1) 4-67.1P MAP AB019437 [2] 146982-147131 (2)
IGHV(II)-74-1 IGHV(II)-74-1*01 P 14q32.33 - - - 59001-6500 (1) 4-74.1P MAP AB019437 [2] 59900-60068 (2)
IGHV(II)-78-1 IGHV(II)-78-1*01 P 14q32.33 - - - 14001-25000 (1) 4-78.1P MAP AB019437 [2] 15431-15705 (2)
IGHV(II)-78-1*02 P 14q32.33 - - - 14001-25000 (1) CM000676.2 MAP IMGT000035 13950->14224 (7)
IGHV(III)-2-1 IGHV(III)-2-1*01 P 14q32.33 - - - 20001-30000 (1) 3-2.1P MAP AB019441 [2] 21563-21864 (2) 174552_ABC10_2_1_000044763900_N17 MK540645 [5] 4735-5036 (7)
IGHV(III)-2-1*02 P 14q32.33 - - - 20001-30000 (1) CM000676.2 MAP IMGT000035 878021-878311 (9)
IGHV(III)-5-1 IGHV(III)-5-1*01 P 14q32.33 - - - 190001-193000 (1) 3-5.1P MAP AB019440 [2] 193545-193643 (2)
IGHV(III)-5-2 IGHV(III)-5-2*01 P 14q32.33 - - - 185001-190000 (1) 3-5.2P MAP AB019440 [2] 187450-187710 (2)
IGHV(III)-5-2*02 P 14q32.33 - - - 185001-190000 (1) CM000676.2 MAP IMGT000035 187450-187710 (7)
IGHV(III)-11-1 IGHV(III)-11-1*01 P 14q32.33 - - - 110001-113000 (1) 3-11.1P MAP AB019440 [2] 112240-112656 (2)
IGHV(III)-13-1 IGHV(III)-13-1*01 P 14q32.33 - - - 88001-100000 (1) 3-13.1P MAP AB019440 [2] 90249-90547 (2)
IGHV(III)-13-1*02 P 14q32.33 - - - 88001-100000 (1) CM000676.2 MAP IMGT000035 737272-737559 (7)(9)
IGHV(III)-16-1 IGHV(III)-16-1*01 P 14q32.33 - - - 60001-65000 (1) 3-16.1P MAP AB019440 [2] 61801-62105 (2)
IGHV(III)-16-1*02 P 14q32.33 - - - 60001-65000 (1) CM000676.2 MAP IMGT000035 708793-709099 (7)
IGHV(III)-22-2 IGHV(III)-22-2*01 P 14q32.33 - - - 166001-169000 (1) 3-22.2P MAP AB019439 [2] 168222-168262 (2) ABC14-954514B22 AC244492 36811-36851 (2)
CH17-60O17 AC245166 153542-153571 (2)
ABC9-43849600N9 AC244473 complement(5623-5663) (2)
ABC9-43993300H10 AC206018 8143-8183 (2)
IGHV(III)-22-2D IGHV(III)-22-2D*01 P 14q32.33 ABC14-954514B22 AC244492 25970-26010 (2)
IGHV(III)-25-1 IGHV(III)-25-1*01 P 14q32.33 - - - 135001-140000 (1) 3-25.1P MAP AB019439 [2] 139140-139981 (2)
IGHV(III)-25-1*02 P 14q32.33 - - - CH17-60O17 AC245166 [3] 124461-124740 ABC12_000049057200_J24 AC280062 [7] 30639..30918 (7)
IGHV(III)-26-1 IGHV(III)-26-1*01 P 14q32.33 - - - 120001-125000 (1) 3-26.1P MAP AB019439 [2] 123568-123874 (2) ABC11-48019600E23 AC244464 [3] 10037-10290
IGHV(III)-26-1*02 P 14q32.33 - - - CH17-60O17 AC245166 [3] 108556-108851 ABC11-48019600E23 AC244464 [3] 10037-10290
ABC12_000049044400_N18 AC279998 [7] complement(5750..6045) (7)
ABC12_000049057200_J24 AC280062 [7] 15101..15396 (7)
IGHV(III)-38-1 IGHV(III)-38-1*01 P 14q32.33 - - - 13001-20000 (1) 3-38.1P MAP AB019439 [2] 15315-15606 (2)
IGHV(III)-38-1*02 P 14q32.33 - - - ABC10-44084700I10 MAP KC162926 [3] 14573-14854
IGHV(III)-38-1*03 P 14q32.33 - - - ABC12_000046338000_F14 MAP AC280057 [84] complement(31616..31897) (7)
IGHV(III)-38-1D IGHV(III)-38-1D*01 P 14q32.33 - - - WI2-1707G1 MAP AC241995 [3] 24838-25115 ABC7-611322I15 AC242184 [4] complement(1231..1508) (7)
IGHV(III)-44 IGHV(III)-44*01 P 14q32.33 - - - 155287-155318 (1,3) V3-44P MAP M99673 [1] 3-44.1P MAP AB019438 [2] (6) 150001-158000 (2)
IGHV(III)-44*02 P 14q32.33 - - - 155287-155318 CM000676.2 MAP IMGT000035 401597-401628 (7) 174779_ABC12_000049207600_G9 MK540650 [5] 35396-35427 (7)
IGHV(III)-44D IGHV(III)-44D*01 P 14q32.33 - - - ABC10-44145400L1 MAP AC233755 [3] 18514-18744
IGHV(III)-47-1 IGHV(III)-47-1*01 P 14q32.33 - - - 100001-110000 (1) 3-47.1P MAP AB019438 [2] 102103-102406 (2) ABC12_000049057200_G6 reverse-complement-of-AC279154 IMGT000057 [6] 8861..9153 (7)
ABC12_000049057200_G6 AC279154 [6] complement(31202..31494) (7)
IGHV(III)-67-2 IGHV(III)-67-2*01 P 14q32.33 - - - 143001-146500 (1) 3-67.2P MAP AB019437 [2] 146324-146422 (2)
IGHV(III)-67-3 IGHV(III)-67-3*01 P 14q32.33 - - - 139001-143000 (1) 3-67.3P MAP AB019437 [2] 140636-140910 (2)
IGHV(III)-67-4 IGHV(III)-67-4*01 P 14q32.33 - - - 135001-139000 (1) 3-67.4P MAP AB019437 [2] 138127-138432 (2) 174552_ABC10_2_1_000044679600_A22 MK540649 [5] 37489-37783 (7)
IGHV(III)-67-4*02 P (9) 14q32.33 - - - ABC10_2_1_000044447900_I14 MAP AC279908 [7] 37301..37595 (2)
IGHV(III)-76-1 IGHV(III)-76-1*01 P 14q32.33 - - - 40001-50000 (1) 3-76.1P MAP AB019437 [2] 49245-49551 (2)
IGHV(III)-82 IGHV(III)-82*01 P 14q32.33 - - - 1-3500 (1) 3-82P MAP AB019437 [2] 1490-1781 (2)
IGHV(IV)-44-1 IGHV(IV)-44-1*01 P 14q32.33 - - - 140001-150000 (1) 4-44.1P MAP AB019438 [2] 143893-144192 (2) 174779_ABC12_000049207600_G9 MK540650 [5] 24012-24300 (7)
IGHV(IV)-44-1*02 P 14q32.33 - - - 140001-150000 (1) CM000676.2 MAP IMGT000035 390075-390542 (8)

MAP: Mapped reference sequences.

IMGT notes:
  1. (1) Arbitrary limits of the DNA sequence assigned to the different IGHV genes.
  2. (2) Limits being V-EXON position when V-REGION can't be delimited.
  3. (3) V-GENE positions in AB019438 Accession number.
  4. (4) the gene IGHV(II)-20-1 is only represented by a V-RS. Its V-REGION is replaced by the Alu Homo-sapiens_IGH_Alu-20-1 preceded by an undetermined region and the Alu Homo-sapiens_IGH_Alu-20-3.
  5. (5) frameshifts in V-REGION: several insertion and deletion in V-REGION.
  6. (6) Owing to a sequence gap and an assembly error, IGHV1-38-4 and IGHV(III)-38-1D positions appear downstream of IGHV4-38-2, whereas they should be located upstream of the IGHV(II)-43-1D - IGHV3-43D - IGHV3-42D -IGHV7-40D duplication.
  7. (7) Positions of V-REGION.
  8. (8) Frameshift in V-REGION: several insertions and deletions.
  9. (9) Truncated pseudogenes not assigned to subgroups with functional genes.
IMGT references:
  1. [1] Matsuda F. et al., Nature Genetics, 3, 88-94 (1993). PMID: 8490662
  2. [2] Matsuda F. et al., J. Exp. Med., 188, 2151-2162 (1998). PMID: 9841928
  3. [3] Watson C.T. et al., Am. J. Hum. Genet., 92, 1-17 (2013). PMID: 23541343
  4. [4] Senaldi H. unpublished.
  5. [5] Rodriguez O.L. and Watson C.T. unpublished.
  6. [6] Rodriguez O.L. et al. unpublished.
Created:
07/10/1996
Last updated:
04/03/2021
Authors:
Emilie Carillon, Dominique Scaviner, Nathalie Pallarès, Joumana Jabado Michaloud, Géraldine Folch, Sofia Kossida and Marie-Paule Lefranc