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Citing this page:Lefranc, M.-P. and Lefranc, G., The T cell receptor FactsBook, Academic Press, London, 398 pages (2001) IMGT/LIGM-DB: IMGT000021 (582960 bp), human (Homo sapiens) TRB locus.

Human (Homo sapiens) TRB locus on chromosome 7 (7q34)

The orientation of the human (Homo sapiens) TRB locus on the chromosome 7 (7q34) is forward (FWD).

Locus representation human TRB

Legend:
Colors are according to IMGT color menu for genes.
The boxes representing the genes are not to scale. Exons are not shown.
A double slash // indicates a gap in genome assembly. Distances in bp (base pair) or in kb (kilobase) associated with a double slash are taken into account in the length of the lines and included in the numbers displayed at the right end of the lines.
A dotted line ... indicates the distance in kb (kilobase) between the locus and its bornes (5' borne and the most 5' gene in the locus and/or 3' borne and the most 3' gene in the locus) on the top and bottom lines, respectively. These distances are not represented at scale and are not included in the numbers displayed at the right ends of these two lines.

TRBV gene designations according to Rowen et al. (1996). Nomenclature adopted by IMGT.
Single arrows show genes whose polarity is opposite to that of the D-J-C-CLUSTER. Double arrows indicate insertion/deletion polymorphisms.

Bornes of the human (Homo sapiens) TRB locus

• PRSS58 (serine protease 58, trypsinogen-like TRYX3, TRY1) (5' borne) has been identified 41 kb upstream of TRBV1 (P), the most 5' gene in the locus.
• EPHB6 (EPH receptor B6) (3' borne) has been identified 41 kb downstream of TRBV30 (F), the most 3' gene in the locus.

T3 to T8 indicate trypsinogen or trypsinogen-like genes. T3 (PRSS3P3, TRY3) is at 7.4 kb upstream of TRBV1. T4 to T8 are localized between TRBV29-1 and TRBD1.

Locus representation with only the functional genes: human (Homo sapiens) TRB

Gene localization is according to data from IMGT/LocusView.
This locus representation with only the functional genes is used with IMGT/GeneFrequency.

Locus representation human TRB

* When needed, indicate the presence of allele(s) with another functionality: see above human (Homo sapiens) TRB locus

Zoom for TRBD and TRBJ genes

zoom

IMGT references:
  1. [1] Lefranc, M.-P. and Lefranc, G., The T cell receptor FactsBook, Academic Press, London, 398 pages (2001).
  2. [2] Lefranc, M.-P., Nomenclature of the human T cell receptor genes, Current Protocols in Immunology, A.1O.1-A.1O.23 (2000).
TRBV genes
  1. [3] Wei, S. et al., Immunogenetics, 40, 27-36 (1994).
  2. [4] Posnett, D.N. et al., The Immunologist, 4, 5-8 (1996).
  3. [5] Rowen, L. et al., Science, 272, 1755-1762 (1996).
TRB D-J-C-CLUSTER
  1. [6] Toyonaga, B. et al., Proc. Natl. Acad. Sci. USA, 82, 8624-8628 (1985).
  2. [7] Tunnacliffe, A. et al., Proc. Natl. Acad. Sci. USA, 82, 5068-5072 (1985).
TRBV alignments
  1. [8] Arden, B. et al., Immunogenetics, 42, 455-500 (1995).
TRBV enhancer (5.5 kb 3' from TRBC2)
  1. [9] Gottschalk, L.R. and Leiden, J.M., Mol. Cell. Biol., 10, 5486-5495 (1990).
Created:
07/10/1996
Last updated:
14/10/2015
Authors:
Géraldine Folch