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Correspondence between V numberings

Correspondence between the IMGT unique Lefranc numbering and the different Kabat numberings (vertical display of examples)
Correspondence between the IMGT unique Lefranc numbering and the different numberings (horizontal display)
Correspondence between numberings for CDR of different lengths (horizontal display)

Click here for: CDR1-IMGT
CDR3-IMGT

CDR-IMGT lengths of the IG proteins quoted as examples

CDR2-IMGT

There are no gaps and therefore no correspondence between the numberings shown in this table.
Click here for correspondence between the IMGT unique Lefranc numbering [1], Kabat [2] and Chothia [3-5] numberings for CDR2 of different lengths.
Brackets indicate the limits of the CDR in each numbering.

Click on the protein name for the CDR2-IMGT 3D structure.
For more information on the proteins, see Protein with known 3D structures-Identification and Colliers de Perles: Human Immunoglobulins 

IMGT               FR2-IMGT              CDR2-IMGT                            FR3-IMGT 
unique                                                                                                                    CDR       CDR2-
numbering [1]          55 [56  57  58  59  60  61  62  63  64  65] 66  67  68  69  70  71  72  73  74                    length [2] IMGT [1]
IGHV [2]              [50  51  52  52A 52B 52C 53  54  55  56  57  58  59  60  61  62  63  64   -  65]                     19        10 
                      [50  51  52  52A 52B 53  54  55  56  57      58  59  60  61  62  63  64   -  65]                     18         9 
                      [50  51  52  52A 53  54  55  56  57          58  59  60  61  62  63  64   -  65]                     17         8 
                      [50  51  52  53  54  55  56  57              58  59  60  61  62  63  64   -  65]                     16         7 

                                                                                                          H2 "canonical    H2       CDR2-      Example
                                                                                                            structure"   length [5] IMGT [1]   of proteins

IGHV [3] [4] [5]       50  51  52 [52a 52b 52c 53  54  55] 56  57  58  59  60  61  62  63  64   -  65           4           6         10      McPC603,4-4-20
                       50  51  52 [52a 52b 53  54  55] 56  57      58  59  60  61  62  63  64   -  65           -           5          9 
                       50  51  52 [52a 53  54  55] 56  57          58  59  60  61  62  63  64   -  65           2,3         4          8       Kol, J539
                       50  51  52 [53  54  55] 56  57              58  59  60  61  62  63  64   -  65           1           3          7       Newm
 IMGT               FR2-IMGT             CDR2-IMGT                            FR3-IMGT 
 unique                                                                                                                   CDR       CDR2-
 numbering [1]         55 [56  57  58  59  60  61  62  63  64  65] 66  67  68  69  70  71  72  73  74                    length [2] IMGT [1]
IGKV [2]               49 [50  51  52                              53  54  55  56] 57  58  59   -  60                       7          3 

                                                                                                           L2 "canonical    L2       CDR2-     Example
                                                                                                             structure"   length [5] IMGT [1]  of proteins

IGKV [3] [4] [5]       49 [50  51  52]                             53  54  55  56  57  58  59   -  60            1          3          3       Rei, McPC603,
J539
 IMGT               FR2-IMGT             CDR2-IMGT                           FR3-IMGT                                     CDR       CDR2-
 unique                                                                                                                   length [2] IMGT [1]
 numbering [1]         55 [56  57  58  59  60  61  62  63  64  65] 66  67  68  69  70  71  72  73  74                       7          3
IGLV [2]               49 [50  51  52                              53  54  55  56] 57  58  59   -  60

                                                                                                           L2 "canonical    L2       CDR2-     Example
                                                                                                             structure"   length [5] IMGT [1]  of proteins

IGLV [3] [4] [5]       49 [50  51  52]                             53  54  55  56  57  58  59   -  60            1          3          3       Kol, Rhe
References:
[1] Lefranc, M.-P., The Immunologist, 7, 132-136 (1999).
[2] Kabat, E.A. et al., In: Sequences of Proteins of Immunological Interest, NIH Publication, 91-3242 (1991).
[3] Chothia, C. and Lesk, A.M., J. Mol. Biol., 196, 901-917 (1987).
[4] Chothia, C. et al., Nature, 342, 877-883 (1989).
[5] Al-Lazikani, B. et al., J. Mol. Biol., 273, 927-948 (1997).

Created: 16/05/2001
Last updated: Friday, 22-Sep-2023 18:14:35 CEST
Author: Lisa Truong