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Correspondence between V numberings

Correspondence between the IMGT unique Lefranc numbering and the different Kabat numberings (vertical display of examples)
Correspondence between the IMGT unique Lefranc numbering and the different numberings (horizontal display)
Correspondence between numberings for CDR of different lengths (horizontal display)

Click here for: CDR1-IMGT
CDR2-IMGT

CDR-IMGT lengths of the IG proteins quoted as examples

CDR3-IMGT

There are no gaps and therefore no correspondence between the numberings shown in this table.
Click here for correspondence between the IMGT unique Lefranc numbering [1], Kabat [2] and Chothia [3-5] numberings for CDR3 of different lengths.
Brackets indicate the limits of the CDR in the three numberings.

For more information on the proteins, see Protein with known 3D structures-Identification and Colliers de Perles: Human Immunoglobulins 

IMGT                                                                                     CDR3-IMGT  
unique            C                                                                                                                            W                  CDR        CDR3-
numbering [1]    104 [105  106  107  108  109  110  111  111.1  111.2  111.3  111.4  112.4  112.3  112.2  112.1  112  113  114  115  116  117] 118                  length [2]  IMGT [1] 

IGHV [2]          92   93   94  [95   96   97   98   99   100    100A   100B   100C   100D   100E   100F   100G  100H 100I 100J 100K 101  102] 103                    19          21
                  92   93   94  [95   96   97   98   99   100    100A   100B   100C   100D   100E   100F   100G  100H 100I           101  102] 103                    17          19
                  92   93   94  [95   96   97   98   99   100    100A   100B   100C                                                  101  102] 103                    11          13
                  92   93   94  [95   96   97   98                                                                     99  100  100A 101  102] 103                     9          11
                                                                                                                                                     H3 "canonical    H3        CDR3-     Example
                                                                                                                                                      structure"    length [5]  IMGT [1]  of proteins

IGHV [3]          92   93   94   95  [96   97   98   99    100   100a   100b   100c   100d   100e   100f   100g  100h 100i 100j 100k 101] 102  103                    17          21
                  92   93   94   95  [96   97   98   99    100   100a   100b   100c   100d   100e   100f   100g  100h 100i           101] 102  103                    15          19      Kol
                  92   93   94   95  [96   97   98   99    100   100a   100b   100c                                                  101] 102  103                     9          13      McPC603
                  92   93   94   95  [96   97   98                                                                     99  100  100a 101] 102  103                     7          11      Newm
IMGT                                                   CDR3-IMGT     
unique            C                                                                                  W                                                            CDR        CDR3-
numbering [1]    104 [105  106  107  108  109  110  111  111.1  112.1  112  113  114  115  116  117] 118                                                            length [2]  IMGT [1]
IGKV [2]          88  [89   90   91   92   93   94   95   95A    95B   95C  95D  95E  95F   96   97]  98                                                              15          15
                  88  [89   90   91   92   93                                    94   95    96   97]  98                                                               9           9
                                                                                                                                                      L3 "canonical   L3        CDR3-     Example
                                                                                                                                                       structure"   length [5]  IMGT [1]  of proteins
IGKV [3] [5]      88   89   90  [91   92   93                                    94   95    96]  97   98                                                   1,2         6           9      Rei, McPC603, J539
IMGT                                                   CDR3-IMGT   
unique            C                                                                                  W                                                            CDR        CDR3-
numbering [1]    104 [105  106  107  108  109  110  111  111.1  112.1  112  113  114  115  116  117] 118                                                            length [2]  IMGT [1]
IGLV [2]          88  [89   90   91   92   93   94   95   95A    95B   95C  95D  95E  95F   96   97]  98                                                              15          15
                  88  [89   90   91   92   93   94                          95   95A  95B   96   97]  98                                                              11          11
                  88  [89   90   91   92   93                                    94   95    96   97]  98                                                               9           9
                                                                                                                                                      L3 "canonical   L3        CDR3-     Example
                                                                                                                                                       structure"   length [5]  IMGT [1]  of proteins
IGLV [3]          88   89   90  [91   92   93  93a                          93b  94   95    96]  97   98                                                    2          8          11      Kol, Rhe
                  88   89   90  [91   92   93                                    94   95    96]  97   98                                                    1          6           9       Newm

IGLV [5]          88   89   90  [91   92   93  94                           95   95a  95b   96]  97   98                                                    2          8          11      Kol, Rhe
                  88   89   90  [91   92   93                                    94   95    96]  97   98                                                    1          6           9       Newm
References:
[1] Lefranc, M.-P., The Immunologist, 7, 132-136 (1999).
[2] Kabat, E.A. et al., In: Sequences of Proteins of Immunological Interest, NIH Publication, 91-3242 (1991).
[3] Chothia, C. and Lesk, A.M., J. Mol. Biol., 196, 901-917 (1987).
[4] Chothia, C. et al., Nature, 342, 877-883 (1989).
[5] Al-Lazikani, B. et al., J. Mol. Biol., 273, 927-948 (1997).

Created: 16/05/2001
Last updated: Friday, 22-Sep-2023 18:14:35 CEST
Author: Lisa Truong